Abstract: A method for performing a therapeutic procedure includes applying therapy to target tissue, measuring a property of the target tissue at a plurality of spaced apart locations along the length of the target tissue, identifying changes in the measured property of the target tissue at each of the plurality of spaced apart locations, identifying a point in time at which the identified change in the measured property occurs at each of the plurality of spaced apart locations, and calculating a pulse wave velocity within the target tissue by comparing a difference between the identified points in time at which the identified change in the measured property occurs at at least two of the plurality of spaced apart locations, wherein the calculated pulse wave velocity is predictive of a response to therapy.

Abstract: A catheter inner member includes an inner member body, including a first side and a second side, the second side opposing the first side. The inner member body includes an inner surface defining an inner member inner lumen and an outer surface defining a surrounding environment. The inner member further includes at least a first flush port and a second flush port in the inner member body. The first flush port and second flush port provide fluid communication between the inner lumen and a surrounding environment. The first flush port disposed on the first side and the second flush port disposed on the second side, wherein the first flush port is axially displaced from the second flush port.