Abstract: Methods, systems, and computer readable media for performing FDG positron emission tomography (PET) quantification, segmentation, and classification of abnormalities are disclosed. One method includes receiving a plurality of magnetic resonance (MR) images corresponding to a target site of a subject and generating three dimensional (3D) area masks of abnormality volumes from the plurality of MR images. The method further includes segmenting the 3D area masks into one or more individual seed images for each of the abnormality volumes and overlaying the one or more individual seed images onto co-registered parametric PET maps to generate kinetic rate parameters for each of the abnormality volumes. The method also includes utilizing the kinetic rate parameters to train a logistic regression engine to predict a target site condition assessment based on a classification of the abnormality volumes.

Abstract: A method for performing dynamic positron emission tomography (PET) is disclosed. The method includes collecting volumetric radioactive measurement data associated with an administered radioactive tracer present in a target site of a subject over multiple scanning intervals, capturing a magnetic resonance image of the target site, and performing a motion correction process to the volumetric radioactive measurement data to produce motion corrected PET data. The method further includes co-registering the magnetic resonance image and motion corrected data to generate a co-registered dynamic PET volume, and applying a model corrected input function (MCIF) to the co-registered dynamic PET volume to calibrate an uptake amount of the radioactive tracer in the target site.

Abstract: A continuous dynamic positron emission tomography (PET) assembly for imaging a target region of a subject. The assembly includes a radioactive tracer isotope injector configured to administer a radioactive isotope into the subject and a scintillator crystal configured to absorb ionizing radiation from the subject and emit scintillator light. The scintillator crystal undertakes the absorption substantially at the same time of the start of administering the radioactive isotope. The assembly also includes a photo detector in communication with the scintillator crystal, wherein the photodetector is configured to detect the emitted scintillation light as input and provide electrical signals as output. The assembly further includes a signal digitizing circuitry converting the output electrical signals into digital data. Moreover, the assembly includes a processor configured to receive the digital data and implement a model to convert the digital data into a three dimensional, tomographic image reconstruction.

Abstract: A time-of-flight positron emission tomography (TOFPET) assembly for detecting lesions of a breast of a subject, wherein the subject may anatomically be defined with a median plane and chest wall-coronal plane. The assembly may comprise: a detector array having at least two or more detector segments. The detector segments may include: a scintillator for placement toward the target, the scintillator having a top edge generally closest to the subject and a detection surface wall aligned closest to surrounding the breast, a photo multiplier opposite the scintillator, and a readout connected to the photo multiplier. The assembly may also comprise a processor that receives the acquired tracer emission signals and converts the signals into a three dimensional, tomographic image reconstruction.

Abstract: This present invention relates to new peptides L-N-substituted-alanyl-N-substituted-glycyl-N-substituted-glycyl-L-aspartyl-N-substituted-glycyl-L-lysyl (SEQ ID NO: 1, where R1—R4 of formula 1 are H and R5 of formula 1 is OH) derivatives which can be used as therapeutic agents for allergy/asthma and a process for preparing the said compounds and its formulation for administration by nasal route.