Patents by Inventor Bilal Sufi

Bilal Sufi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enediyne compounds, conjugates thereof, and uses and methods therefor
    Patent number: 9156850
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 13, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR
    Publication number: 20140193438
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 10, 2014
    Applicant: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • Enediyne compounds, conjugates thereof, and uses and methods therefor
    Patent number: 8709431
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: April 29, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • Chemical linkers and cleavable substrates and conjugates thereof
    Patent number: 8461117
    Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: June 11, 2013
    Assignee: Medarex, Inc.
    Inventors: Bilal Sufi, Vincent Guerlavais, Liang Chen, Sanjeev Gangwar, Qian Zhang, David B. Passmore
  • Chemical linkers and conjugates thereof
    Patent number: 8399403
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: March 19, 2013
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Kilian Horgan, Zhi-Hong Li, Bilal Sufi
  • Cytotoxic compounds and conjugates
    Patent number: 7968586
    Abstract: The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: June 28, 2011
    Assignee: Medarex, Inc.
    Inventors: Sanjeev Gangwar, Bilal Sufi
  • CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF
    Publication number: 20100145036
    Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: December 28, 2007
    Publication date: June 10, 2010
    Applicant: Medarex, Inc.
    Inventors: Bilal Sufi, Vincent Guerlavais, Liang Chen, Sanjeev Gangwar, Qian Zhang, David B. Passmore
  • Cytotoxic compounds and conjugates with cleavable substrates
    Patent number: 7714016
    Abstract: The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: May 11, 2010
    Assignee: Medarex, Inc.
    Inventors: Sanjeev Gangwar, Bilal Sufi
  • CHEMICAL LINKERS AND CONJUGATES THEREOF
    Publication number: 20100092496
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: November 2, 2009
    Publication date: April 15, 2010
    Applicant: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • Chemical linkers and conjugates thereof
    Patent number: 7691962
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: April 6, 2010
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • Cytotoxic compounds and conjugates
    Patent number: 7517903
    Abstract: The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: April 14, 2009
    Assignee: Medarex, Inc.
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Zhi-Hong Li, Bilal Sufi
  • Cytotoxic Compounds and Conjugates
    Publication number: 20080293800
    Abstract: The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
    Type: Application
    Filed: November 9, 2006
    Publication date: November 27, 2008
    Applicant: MEDAREX, INC.
    Inventors: Sanjeev Gangwar, Bilal Sufi
  • Antibody-Drug Conjugates and Methods of Use
    Publication number: 20080279868
    Abstract: The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
    Type: Application
    Filed: September 26, 2006
    Publication date: November 13, 2008
    Applicant: Medarex, Inc.
    Inventors: Sharon Elaine Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Kilian Horgan, Bilal Sufi, Haichun Huang, David John King, Chin Pan, Josephine M. Cardarelli
  • Cytotoxic compounds and conjugates with cleavable substrates
    Publication number: 20060247295
    Abstract: The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
    Type: Application
    Filed: April 6, 2006
    Publication date: November 2, 2006
    Applicant: Medarex, Inc.
    Inventors: Sanjeev Gangwar, Bilal Sufi
  • Chemical linkers and conjugates thereof
    Publication number: 20060024317
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 2, 2006
    Applicant: Medarex, Inc
    Inventors: Sharon Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • Cytotoxic compounds and conjugates
    Publication number: 20060004081
    Abstract: The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
    Type: Application
    Filed: May 19, 2005
    Publication date: January 5, 2006
    Applicant: Medarex, Inc.
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Zhi-Hong Li, Bilal Sufi