Patents by Inventor Biliang Zhang

Biliang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11485752
    Abstract: The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleotides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: November 1, 2022
    Assignee: GUANGZHOU RIBOBIO CO., LTD.
    Inventors: Biliang Zhang, Wei Wang
  • Patent number: 11393853
    Abstract: An array substrate and a manufacturing method thereof are disclosed. The method includes: forming a first thin film transistor which includes a first semiconductor layer, a first gate electrode, a first drain electrode and a first source electrode; forming a second thin film transistor which includes a second semiconductor layer, a second gate electrode, a second drain electrode and a second source electrode; and forming a dielectric layer which spaces the first semiconductor layer apart from the second semiconductor layer; the method further includes: processing the same layer to form at least one selected from the group consisting of the first gate electrode, the first drain electrode and the first source electrode, at least one selected from the group consisting of the second gate electrode, the second drain electrode and the second source electrode, and the dielectric layer by the same layer.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 19, 2022
    Assignees: Hefei BOE Optoelectronics Technology Co., Ltd., BOE Technology Group Co., Ltd.
    Inventors: Kui Gong, Biliang Dong, Xianxue Duan, Zhihai Zhang
  • Publication number: 20210253623
    Abstract: Disclosed are a new-type nucleic acid unit for construction of a polymeric nucleic acid and the polymeric nucleic acid for interfering with target gene expression. In the present application, by design and construction of the new-type nucleic acid unit and the self-assembled polymeric nucleic acid thereof, multiple target interference may be realized, wherein the same may be used for inhibiting multiple gene expressions in a signaling pathway of disease occurrence or development, or simultaneously inhibiting multiple disease target genes expression, possessing broad application prospects in multiple subject fields such as biology and chemistry. The polymeric nucleic acid may target multiple sequences simultaneously, wherein the sequences may be located in one or more genes.
    Type: Application
    Filed: July 20, 2018
    Publication date: August 19, 2021
    Inventors: Biliang ZHANG, Xiuqun YANG, Dmitry SAMARSKY
  • Publication number: 20210189435
    Abstract: Provided is a system for DNA editing, comprising crRNA and tracrRNA. The crRNA is an RNA shown in formula I: Nx-ncrRNA (formula I), wherein the Nx is a spacer, and the ncrRNA is an RNA shown in SEQ ID NOs. 1-4 of the Sequence Listing. The tracrRNA is an RNA shown in SEQ ID NOs. 5-8 of the Sequence Listing.
    Type: Application
    Filed: May 24, 2018
    Publication date: June 24, 2021
    Inventor: Biliang ZHANG
  • Publication number: 20200369703
    Abstract: The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.
    Type: Application
    Filed: December 26, 2017
    Publication date: November 26, 2020
    Inventors: Biliang ZHANG, Wei WANG
  • Patent number: 10709729
    Abstract: Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: July 14, 2020
    Assignees: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES, GUANGZHOU RIBOBIO CO., LTD.
    Inventors: Bill Biliang Zhang, Micky Daniel Tortorella, Zhe Wang, Xiuqun Yang, Qiuyun Wang
  • Publication number: 20180250323
    Abstract: Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.
    Type: Application
    Filed: December 23, 2015
    Publication date: September 6, 2018
    Inventors: Bill Biliang ZHANG, Micky Daniel TORTORELLA, Zhe WANG, Xiuqun YANG, Qiuyun WANG
  • Publication number: 20040146941
    Abstract: A chemical tag can include a core and a plurality of substituents attached directly to the core. The substituents of each chemical tag form a subset of a closed set of possible substituents. The tag can be used to track an object.
    Type: Application
    Filed: November 3, 2003
    Publication date: July 29, 2004
    Inventors: Biliang Zhang, Zhiyong Cui
  • Publication number: 20040126792
    Abstract: The present invention relates to the synthesis of novel compounds for the inhibition of peptide synthesis in the ribosome. It also relates to improved methods for directly monitoring peptide bond formation in the ribosome. These compounds can be used for high throughput screening of proposed therapeutically active drug species (e.g., antibiotics) targeted to ribosomes.
    Type: Application
    Filed: September 17, 2003
    Publication date: July 1, 2004
    Inventor: Biliang Zhang
  • Publication number: 20030165849
    Abstract: Methods for synthesizing RNA molecules whose 5′-terminus comprises a thiol group are disclosed. The present invention discloses the formation of 5′-HS-PEG-GMP-RNA and 5′-GMPS-RNA which upon alkaline phosphatase treatment, independently lead to a 5′-HS-RNA molecule.
    Type: Application
    Filed: November 27, 2001
    Publication date: September 4, 2003
    Inventors: Biliang Zhang, Zhiyong Cui, Lei Zhang