Abstract: The present disclosure generally relates to surgical instruments having variable stiffness, and more particularly, surgical instruments having variable stiffness for ophthalmic surgical procedures. In certain embodiments, a surgical instrument includes a base unit, a probe, a stiffener, and an actuation mechanism. The stiffener is formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. The actuation mechanism is configured to actuate the stiffener along the length of the probe and adjust the stiffness of the probe, thus providing a user better control of the surgical instrument. The actuation mechanism includes a stiffener biasing device configured to apply a first biasing force against the stiffener in the distal direction and, in some embodiments, a control member configured to lock the stiffener in a position along the length of the probe.

Abstract: In one embodiment, a method to synthesize highly fluorescent complexes is disclosed. The highly fluorescent complexes are synthesized by using inorganic nanoparticles, coupling agents, linkers, and fluorescent dye molecules. The unique nanoparticle-dye complexes (referred to as “SN-dye”) can provide ultra-bright fluorescent labelling. This is demonstrated by coupling the complexes to the antibody and subsequently using the conjugated antibody for more sensitive immunological detection in flow cytometry applications.

Abstract: A surgical instrument includes a base unit, a probe, a stiffener, and an actuation mechanism. The stiffener is formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. The actuation mechanism is configured to actuate the stiffener along the length of the probe and adjust the stiffness of the probe, thus providing a user better control of the surgical instrument. The actuation mechanism includes a stiffener biasing device configured to apply a first biasing force against the stiffener in the distal direction and, in some embodiments, a control member configured to lock the stiffener in a position along the length of the probe.

Abstract: The present disclosure generally relates to microsurgical instruments having variable stiffness such as microsurgical instruments having variable stiffness for ophthalmic surgical procedures. In one embodiment, a surgical instrument includes a probe and a stiffener assembly. The stiffener assembly further includes a stiffener formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. Actuation of the stiffener along the length of the probe adjusts the stiffness of the probe, thus providing a user better control of the surgical instrument.

Abstract: The present disclosure generally relates to microsurgical instruments having variable stiffness such as microsurgical instruments having variable stiffness for ophthalmic surgical procedures. In one embodiment, a surgical instrument includes a probe and a stiffener assembly. The stiffener assembly further includes a stiffener formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. Actuation of the stiffener along the length of the probe adjusts the stiffness of the probe, thus providing a user better control of the surgical instrument.

Abstract: The present disclosure generally relates to surgical instruments having variable stiffness, and more particularly, surgical instruments having variable stiffness for ophthalmic surgical procedures. In certain embodiments, a surgical instrument includes a base unit, a probe, a stiffener, and an actuation mechanism. The stiffener is formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. The actuation mechanism is configured to actuate the stiffener along the length of the probe and adjust the stiffness of the probe, thus providing a user better control of the surgical instrument. The actuation mechanism includes a stiffener biasing device configured to apply a first biasing force against the stiffener in the distal direction and, in some embodiments, a control member configured to lock the stiffener in a position along the length of the probe.

Abstract: A multi-level, multi-connector assembly that may include high-speed, low-speed and power terminals is protected from electromagnetic interference. The multi-level, multi-port connector assembly includes a bottom port connector connected with a circuit board, a top port connector positioned over the bottom port connector, and an electromagnetic shielding cage positioned over both the top port connector and the bottom port connector to provide shielding from a range of electromagnetic interference (EMI) for the top port connector and the bottom port connector. Each of the top and bottom port connectors comprise power and communication signal conductors, where the signal conductors are operable to conduct at least high-speed communication signals.

Abstract: The present disclosure generally relates to microsurgical instruments having variable stiffness such as microsurgical instruments having variable stiffness for ophthalmic surgical procedures. In one embodiment, a surgical instrument includes a probe and a stiffener assembly. The stiffener assembly further includes a stiffener formed of a hollow tubular member substantially surrounding at least a portion of a length of the probe. Actuation of the stiffener along the length of the probe adjusts the stiffness of the probe, thus providing a user better control of the surgical instrument.

Abstract: Systems, methods, and devices for inserting an intraocular lens (IOL) into an eye may be provided. An example IOL injector device may include a housing, wherein the housing comprises a first end and a second end. The IOL injector device further may include a battery and a plunger disposed within the housing. The IOL injector device further may include a motor powered by the battery and configured to cause the plunger to translate in the housing. The IOL injector device further may include a user interface disposed on the housing, wherein the user interface receives user input to start translation of the plunger.

Abstract: The present disclosure is directed to devices, systems, and methods directed to mounting a plunger tip to a plunger of an IOL injection device. A plunger tip wrench that is operable to releasably retain a plunger tip may be coupled to a holder extending from an end of the IOL injection device to align the plunger tip with the plunger of the IOL injection device. In some instances, the IOL injection device may include a motor and use a back electromotive force (EMF) of the motor to detect a position of the plunger as it is extended to engage the plunger tip. The plunger tip may be positioned relative to the plunger such that the plunger will engage the plunger tip within the entire range of a negative error position and a positive error position.

Abstract: A flow shelf roller having an outer circumference, a radially central hub, and an axially central bore forming an inner circumference through the central hub. The inner circumference of each roller has at least one axial relief channel formed therein along the length of the axial bore. In a more particular embodiment, the axial relief channel is formed including a non-perpendicular angle with respect to the inner circumference of the roller. In a more particular embodiment, the axial relief channel includes at least one of an angled chamfer and a radiused corner, adjacent to the inner circumference of the first roller. The disclosure also includes a roller flow shelf including a flow bed roller having any or all of the aforementioned characteristics.

Abstract: A flow shelf roller having an outer circumference, a radially central hub, and an axially central bore forming an inner circumference through the central hub. The inner circumference of each roller has at least one axial relief channel formed therein along the length of the axial bore. In a more particular embodiment, the axial relief channel is formed including a non-perpendicular angle with respect to the inner circumference of the roller. In a more particular embodiment, the axial relief channel includes at least one of an angled chamfer and a radiused corner, adjacent to the inner circumference of the first roller. The disclosure also includes a roller flow shelf including a flow bed roller having any or all of the aforementioned characteristics.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: The present disclosure is directed to devices, systems, and methods directed to mounting a plunger tip to a plunger of an IOL injection device. A plunger tip wrench that is operable to releasably retain a plunger tip may be coupled to a holder extending from an end of the IOL injection device to align the plunger tip with the plunger of the IOL injection device. In some instances, the IOL injection device may include a motor and use a back electromotive force (EMF) of the motor to detect a position of the plunger as it is extended to engage the plunger tip. The plunger tip may be positioned relative to the plunger such that the plunger will engage the plunger tip within the entire range of a negative error position and a positive error position.

Abstract: The present disclosure is directed to devices, systems, and methods directed to mounting a plunger tip to a plunger of an IOL injection device. A plunger tip wrench that is operable to releasably retain a plunger tip may be coupled to a holder extending from an end of the IOL injection device to align the plunger tip with the plunger of the IOL injection device. In some instances, the IOL injection device may include a motor and use a back electromotive force (EMF) of the motor to detect a position of the plunger as it is extended to engage the plunger tip. The plunger tip may be positioned relative to the plunger such that the plunger will engage the plunger tip within the entire range of a negative error position and a positive error position.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.