Patents by Inventor Bill Downes

Bill Downes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS COMPRISING 15-HETRE AND METHODS OF USE THEREOF
    Publication number: 20220133669
    Abstract: Provided herein are pharmaceutical compositions comprising 15-HETrE and methods of using the same to treat a variety of conditions and disorders.
    Type: Application
    Filed: October 29, 2021
    Publication date: May 5, 2022
    Inventors: John Climax, David Coughlan, Bill Downes, Tien Nghiem, Markus Weissbach, Moayed Hamza
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF FATTY ACIDS
    Publication number: 20200181064
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Application
    Filed: December 5, 2019
    Publication date: June 11, 2020
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • Pharmaceutically acceptable salts of fatty acids
    Patent number: 10544088
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: January 28, 2020
    Assignee: DS Biopharma Limited
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • Pharmaceutically acceptable salts of fatty acids
    Patent number: 10017453
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: July 10, 2018
    Assignee: DS BIOPHARMA LIMITED
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF FATTY ACIDS
    Publication number: 20180118655
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Application
    Filed: December 1, 2017
    Publication date: May 3, 2018
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • Methods of making 15-hydroxy fatty acid derivatives
    Patent number: 9670126
    Abstract: The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-?-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 6, 2017
    Assignee: DIGNITY SCIENCES LIMITED
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • Pharmaceutically Acceptable Salts of Fatty Acids
    Publication number: 20150152034
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Application
    Filed: November 17, 2014
    Publication date: June 4, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • METHODS OF MAKING 15-HYDROXY FATTY ACID DERIVATIVES
    Publication number: 20150119593
    Abstract: The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-?-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA, 15-OHEPA, AND/OR 15-HETRE AND METHODS OF REDUCING SEBUM PRODUCTION USING SAME
    Publication number: 20150094370
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes, John Climax
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA, 15-OHEPA, AND/OR 15-HETRE AND METHODS OF REDUCING SEBUM PRODUCTION USING SAME
    Publication number: 20130274338
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventors: Mehar Manku, David Coughlan, Bill Downes, John Climax
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA, 15-OHEPA, AND/OR 15-HETRE AND METHODS OF REDUCING SEBUM PRODUCTION USING SAME
    Publication number: 20130267598
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.
    Type: Application
    Filed: February 22, 2013
    Publication date: October 10, 2013
    Inventors: Mehar Manku, David Coughlan, Bill Downes, John Climax