Patents by Inventor Bill H. Diplas

Bill H. Diplas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Directing treatments for glioblastoma based on identifying a somatic structural rearrangement upstream from TERT gene
    Patent number: 11697845
    Abstract: The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, either TERTp mutation leading to telomerase activation or ATRX-mutation leading to an alternative lengthening of telomeres phenotype (ALT). However, about 20% of glioblastomas lack alterations in TERTp and IDH. These tumors, designated TERTpWT-IDHWT glioblastomas, did not have well-established genetic biomarkers or defined mechanisms of telomere maintenance. The genetic landscape of TERTpWT-IDHWT glioblastoma includes tumors that have chromosomal rearrangements upstream of TERT. These rearrangements define a novel molecular subgroup of glioblastoma, that is a telomerase-positive subgroup driven by TERT-structural rearrangements (IDHWT-TERTSV).
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: July 11, 2023
    Assignee: Duke University
    Inventors: Hai Yan, Bill H. Diplas
  • Directing Treatments For Glioblastoma
    Publication number: 20210002702
    Abstract: The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, either TERTp mutation leading to telomerase activation or ATRX-mutation leading to an alternative lengthening of telomeres phenotype (ALT). However, about 20% of glioblastomas lack alterations in TERTp and IDH. These tumors, designated TERTpWT-IDHWT glioblastomas, did not have well-established genetic biomarkers or defined mechanisms of telomere maintenance. The genetic landscape of TERTpWT-IDHWT glioblastoma includes tumors that have chromosomal rearrangements upstream of TERT. These rearrangements define a novel molecular subgroup of glioblastoma, that is a telomerase-positive subgroup driven by TERT-structural rearrangements (IDHWT-TERTSV).
    Type: Application
    Filed: March 8, 2019
    Publication date: January 7, 2021
    Inventors: Hai Yan, Bill H. Diplas
  • Methods for rapid and sensitive detection of hotspot mutations
    Patent number: 10633711
    Abstract: Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: April 28, 2020
    Assignee: Duke University
    Inventors: Hai Yan, Yiping He, Rui Yang, Bill H. Diplas, Landon Hansen, Darell Bigner
  • METHODS FOR RAPID AND SENSITIVE DETECTION OF HOTSPOT MUTATIONS
    Publication number: 20170247765
    Abstract: Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and exquisitely localized mutations. The ability to distinguish between sequences that differ only by one nucleotide and which may be present in very low ratios is essential for such an assay.
    Type: Application
    Filed: August 24, 2015
    Publication date: August 31, 2017
    Applicant: Duke University
    Inventors: Hai Yan, Yiping He, Rui Yang, Bill H. Diplas, Landon Hansen, Darell Bigner