Abstract: Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or thio)benzimidazoles and [benzimidazolyl(sulfinyl or thio)alkyl]anilines.

Abstract: A regioselective process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester is disclosed. A controlled aqueous coupling reaction between .beta.-methyl-L-aspartate-N-carboxyanhydride and L-phenylalanine produces the aspartyl methyl ester of .alpha.-L-aspartyl-L-phenylalanine which is subsequently hydrolyzed and selectively esterified without isolation. The hydrochloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is selectively precipitated from the esterification mixture, can be neutralized to .alpha.-L-aspartyl-L-phenylalanine methyl ester.

Abstract: A composition and method for improving feed utilization or tissue production in animals are disclosed. At least one substituted phenylphosphinic acid derivative or pharmaceutically acceptable salts thereof is administered as a feed supplement at a daily dosage between about 0.005 and 350 mg/animal. The specific daily dosage depends on the specie, weight of the animal and the desired production trait to be improved.

Abstract: Catalytic asymmetric hydrogenation of the Z geometric isomer of a compound of the formula ##STR1## wherein at least one of R and R.sup.1 represents hydrogen and the other represents hydrogen, lower alkyl or aryl; R.sup.2 represents ##STR2## wherein R.sup.4 and R.sup.5 each independently represent hydrogen, lower alkyl or aryl, R.sup.6 represents hydrogen, lower alkyl, aryl or an alkali metal; and R.sup.3 represents ##STR3## wherein R.sup.7 and R.sup.8 each independently represent lower alkyl or aryl; provided that, when R.sup.3 is ##STR4## R.sup.2 is --CN, in the presence of a homogeneous, coordination complex catalyst comprising rhodium, iridium or ruthenium in combination with an optically active bis phosphine ligand provides an outstanding level of optical purity.

Abstract: New optically active bis phosphine compounds which are usful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.

Abstract: Catalytic asymmetric hydrogenation of a compound of the formula ##STR1## wherein R, R.sup.1 and R.sup.2 each independently represent hydrogen, substituted or unsubstituted alkyl having from 1 to 5 carbon atoms or substituted or unsubstituted aryl, and R.sup.3 represents substituted or unsubstituted alkyl having from 1 to 5 carbon atoms or substituted or unsubstituted aryl, provided that, if only one of R and R.sup.1 is hydrogen the Z geometric isomer is hydrogenated, in the presence of a homogeneous, coordination complex catalyst comprising rhodium, iridium or ruthenium in combination with an optically active bis phosphine ligand provides an excellent level of optical purity.

Abstract: A process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester wherein .alpha.-L-aspartyl-L-phenylalanine is contacted with a reaction medium comprising water, methanol and a hydrogen halide to form a solid hydrogen halide salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester which can be separated and converted to .alpha.-L-aspartyl-L-phenylalanine methyl ester.

Abstract: New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.

Abstract: New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.

Abstract: A process for the preparation of 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) wherein .alpha.-acetamido-4-hydroxy-3-alkoxy-cinnamic acid acetate is subjected to catalytic asymmetric hydrogenation to yield an optically active mixture N-acetyl-3-(4-hydroxy-3-alkoxyphenyl)-alanine acetate, with the L enantiomorph being present in a major amount and the D enantiomorph being present in a minor amount, from which N-acetyl-3-(4-hydroxy-3-alkoxyphenyl)-L-alanine acetate can be easily recovered and is then converted to L-DOPA.Novel precursors for L-DOPA are prepared in the process of this invention.

Abstract: A process for the preparation of .alpha.-L-aspartyl-L-phenylalanine alkyl esters wherein L-phenylalanine is reacted with N-protected-L-aspartic anhydride, the resulting product is treated to yield .alpha.-L-aspartyl-L-phenylalanine which is esterified with an alkanol to yield an .alpha.-L-aspartyl-L-phenylalanine alkyl ester which is recovered.Novel precursors for .alpha.-L-aspartyl-L-phenylalanine alkyl esters are prepared in the process of this invention.