Patents by Inventor Billy J. Molloy

Billy J. Molloy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions, methods, and kits for quantifying methotrexate
    Patent number: 10882862
    Abstract: The invention relates to stable, isotopically labeled compounds for use in mass spectrometry analysis for quantifying methotrexate in a sample. Exemplary compounds include isotopically labeled variants of methotrexate.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: January 5, 2021
    Assignee: Micromass UK Limited
    Inventors: Donald Peter Cooper, Billy J. Molloy
  • COMPOSITIONS, METHODS, AND KITS FOR QUANTIFYING METHOTREXATE
    Publication number: 20200216453
    Abstract: The invention relates to stable, isotopically labeled variants of methotrexate for use in mass spectrometry analysis for quantifying methotrexate in a sample. The compounds have the structure wherein each of Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11<Y12-Y13 and Y14 is independently selected from carbon or carbon-13; and wherein at least 5 of Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, Y12, Y13 and Y14 are carbon-13.
    Type: Application
    Filed: June 5, 2017
    Publication date: July 9, 2020
    Applicant: Micromass UK Limited
    Inventors: Donald Peter Cooper, Billy J. Molloy
  • Measurement of 25-hydroxyvitamin D3 and C3-epi-25-hydroxyvitamin D3
    Patent number: 8729463
    Abstract: The invention describes a method of quantification of an analyte selected from the group consisting of 25-hydroxyvitamin D3 and C3-epi-25-hydroxyvitamin D3 in a specimen containing the analyte; comprising the steps of subjecting the specimen to UPLC reverse-phase separation; and; detecting the protonated precursor pseudo-molecular ion of the analyte using a mass spectrometry technique to determine the amount of the analyte.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: May 20, 2014
    Assignee: Waters Technologies Corporation
    Inventors: Lisa J. Calton, Billy J. Molloy
  • Detection And Quantification Of Vitamin D Metabolites Using An Alkylamine To Form Stable Adducts For Mass Spectrometric Analysis
    Publication number: 20130252342
    Abstract: The invention describes a method of determining the amount of an analyte in a sample wherein the analyte comprises one or more vitamin D metabolites; comprising the steps of; contacting the analyte with an alkylamine to form an alkylamine adduct; subjecting the adduct to a MS technique to determine the amount of the adduct; and calculating the amount of the analyte equivalent to the amount of the adduct.
    Type: Application
    Filed: March 29, 2011
    Publication date: September 26, 2013
    Applicant: MICROMASS UK LIMITED
    Inventors: Lisa J. Calton, Billy J. Molloy
  • Measurement Of 25-Hydroxyvitamin D3 And C3 EP1-25-Hydroxyvitamin D3
    Publication number: 20130126721
    Abstract: The invention describes a method of quantification of an analyte selected from the group consisting of 25-hydroxyvitamin D3 and C3-epi-25-hydroxyvitamin D3 in a specimen containing the analyte; comprising the steps of subjecting the specimen to UPLC reverse-phase separation; and; detecting the protonated precursor pseudo-molecular ion of the analyte using a mass spectrometry technique to determine the amount of the analyte.
    Type: Application
    Filed: March 28, 2011
    Publication date: May 23, 2013
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: Lisa J. Carlton, Billy J. Molloy