Patents by Inventor Billy M. Hargis
Billy M. Hargis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11883489Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: GrantFiled: September 15, 2020Date of Patent: January 30, 2024Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Publication number: 20220347234Abstract: The present invention provides Bacillus isolates, as well as probiotic and animal feed compositions comprising said isolates, which may be included in the diet of poultry to improve growth performance with reduced energy diets. Methods of using these compositions to improve nutritional uptake or to reduce the incidence of footpad dermatitis in poultry are also provided.Type: ApplicationFiled: June 22, 2020Publication date: November 3, 2022Inventors: Billy M. Hargis, Lucas Elzie Graham, Kyle Dean Teague, Juan David Latorre, Samuel J. Rochell
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Publication number: 20210000947Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: ApplicationFiled: September 15, 2020Publication date: January 7, 2021Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Patent number: 10780162Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: GrantFiled: April 9, 2019Date of Patent: September 22, 2020Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Publication number: 20190231869Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: ApplicationFiled: April 9, 2019Publication date: August 1, 2019Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Patent number: 10258688Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: GrantFiled: November 29, 2016Date of Patent: April 16, 2019Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Publication number: 20170143823Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: ApplicationFiled: November 29, 2016Publication date: May 25, 2017Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
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Publication number: 20150297714Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.Type: ApplicationFiled: October 29, 2013Publication date: October 22, 2015Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Billy M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez, Amanda Wolfenden
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Patent number: 8367058Abstract: Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.Type: GrantFiled: April 21, 2011Date of Patent: February 5, 2013Assignees: The United States of America, as Represented by the Secretary of Agriculture, The Board of Trustees of the University of ArkansasInventors: Billy M. Hargis, Stacy E. Higgins, Lisa Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue
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Publication number: 20110200561Abstract: Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.Type: ApplicationFiled: April 21, 2011Publication date: August 18, 2011Applicants: Board of Trustees of the University of Arkansas, United States of America, as represented by the Secretary of AgricultureInventors: Billy M. Hargis, Stacy E. Higgins, Lisa Bielke, Guillermo L. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue
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Patent number: 7951579Abstract: Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.Type: GrantFiled: June 23, 2006Date of Patent: May 31, 2011Assignees: Board of Trutees of the University of Arkansas, The United States of America as represented by the Secretary of AgricultureInventors: Billy M. Hargis, Stacy E. Higgins, Lisa Bielke, Guillermo I. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue
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Publication number: 20040241150Abstract: The invention comprises a method of screening cecal microflora for in vitro competition against select enteric pathogens, as well as the characterization of specific cecal microflora. The invention also comprises using the characterized competitive exclusion culture against select enteric pathogens in poultry, porcine, and ruminant, and humans. Selection of competitive isolates was achieved by combining Salmonella enteritidis (SE), adult broiler cecal microflora, and an indicator broth, which was then placed in a microtiter plate. Potential isolates were then challenged individually against Salmonella enteritidis. The ability of the selective isolates was determined by qualitative evaluation of Salmonella growth on brilliant green agar after the challenge. Isolates analyzed included but are not limited to; Bacillus species, Staphylococcus species, Escherichia species, Citrobacter species, Enterococcus species, Proteus species, Enterobacter species, Salmonella species, and Klebsiella species.Type: ApplicationFiled: April 20, 2004Publication date: December 2, 2004Inventors: Billy M. Hargis, Daniel J. Donoghue, Ann M. Donoghue, Noel K. Neighbor, Lisa R. Bielke, Lisa A. Newberry, Guillermo I. Tellez, Gerardo Nava
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Publication number: 20040219519Abstract: We recently isolated bacteriophages from wastewater that lyse a primary poultry isolate of Salmonella enteritidis (SE). We evaluated the host range bacteriophage isolates and found that they have the ability to also lyse up to 7 other Salmonella isolates, as well as E. coli, and Klebsiella sp. when plated using soft agar overlay technique. Further, we found that addition of bacteriophage to carcass rinse samples significantly reduced the amount of recoverable Salmonella in both laboratory and field trial settings. The invention also comprises selecting appropriate bacteriophages that target a specific pathogen, and identifying beneficial microflora that would serve as an alternative host. We were able to identify several such alternative hosts from the beneficial microflora selected in our competitive exclusion project.Type: ApplicationFiled: April 5, 2004Publication date: November 4, 2004Inventors: Billy M. Hargis, Stacy E. Higgins, Lisa Bielke, Guillermo I. Tellez, Lisa A. Newberry, Gerardo Nava, Ann M. Donoghue, Daniel J. Donoghue
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Patent number: 6518307Abstract: The present invention provides a method for controlling microbial populations in the gastrointestinal tract of animals. The method comprises the step of orally administering an effective amount of a peracid to an animal. Percarboxylic acids useful in this invention include peracetic acid, perpropionic acid, perbutyric acid, peroctanoic acid, perglycolic acid, perglutaric acid, persuccinic acid, perlactic acid, percitric acid, perdecanoic acid or mixtures thereof. These percarboxylic acids have been found to provide good antimicrobial action with good stability in aqueous streams. In addition to peracetic, peroctanoic and perdecanoic, particularly preferred percarboxylic acids include perpropionic, perbutyric, perglycolic, perlactic and percitric acids.Type: GrantFiled: October 17, 2001Date of Patent: February 11, 2003Assignees: Lynntech, Inc., The Texas A&M University SystemInventors: K. Scott McKenzie, Anthony Giletto, G. Duncan Hitchens, Billy M. Hargis, Kelly L. Herron
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Publication number: 20020115719Abstract: The present invention provides a method for controlling microbial populations in the gastrointestinal tract of animals. The method comprises the step of orally administering an effective amount of a peracid to an animal. Percarboxylic acids useful in this invention include peracetic acid, perpropionic acid, perbutyric acid, peroctanoic acid, perglycolic acid, perglutaric acid, persuccinic acid, perlactic acid, percitric acid, perdecanoic acid or mixtures thereof. These percarboxylic acids have been found to provide good antimicrobial action with good stability in aqueous streams. In addition to peracetic, peroctanoic and perdecanoic, particularly preferred percarboxylic acids include perpropionic, perbutyric, perglycolic, perlactic and percitric acids.Type: ApplicationFiled: October 17, 2001Publication date: August 22, 2002Applicant: Lynntech, Inc.Inventors: K. Scott McKenzie, Anthony Giletto, G. Duncan Hitchens, Billy M. Hargis, Kelly L. Herron
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Patent number: 6342528Abstract: The invention is a process for preventing microbial growth in the digestive tract of living vertebrate animals, particularly food animals. Control of microbial growth is achieved by the step of applying a percarboxylic acid or a mixture of percarboxylic acids to an aqueous stream which is subsequently consumed orally by the animal. The formulation can also be mixed into food items or into particulate or similar materials, or packaged in ingestible capsules, whereby the active ingredient enters the body of the animal through the oral cavity through feeding behavior, or food scavenging, or particulate scavenging activities of the animal. Formulations may also be sprayed onto the outside of the animal and taken orally.Type: GrantFiled: January 18, 2000Date of Patent: January 29, 2002Assignee: Lynntech, Inc.Inventors: K. Scott McKenzie, Anthony Giletto, G. Duncan Hitchens, Billy M. Hargis, Kellie L. Herron
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Patent number: 5891443Abstract: Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro to a mitogen effective for secondary stimulation thereof, and then virally transformed to produce an immortal cell line. When cultured in vitro, the cell lines produce and secrete immune lymphokines which may be administered to fowl to increase their resistance to infections.Type: GrantFiled: September 15, 1997Date of Patent: April 6, 1999Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas & M University System CollegeInventors: Michael H. Kogut, John R. DeLoach, Larry H. Stanker, Rita B. Moyes, Billy M. Hargis
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Patent number: 5698193Abstract: A method of combatting microbial infections, including Escherichia coli and Salmonella infections, in immature birds by in ovo administration of an immune lymphokine (ILK) containing preparation in an amount effective to combat microbial infections in immature birds. A method of combatting microbial infections in immature birds by upregulating the production of endogenous Interleukin-8 (IL-8) in the bird. A method of combatting microbial infections in immature birds by in ovo administration of immune lymphokine (ILK).Type: GrantFiled: December 27, 1994Date of Patent: December 16, 1997Assignees: The United States of America as represented by the Department of Agriculture, The Texas A&M University SystemInventors: Michael H. Kogut, John R. DeLoach, Billy M. Hargis, Edward D. McGruder
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Patent number: 5691200Abstract: Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro to a mitogen effective for secondary stimulation thereof, and then virally transformed to produce an immortal cell line. When cultured in vitro, the cell lines produce and secrete immune lymphokines which may be administered to fowl to increase their resistance to infections.Type: GrantFiled: July 3, 1996Date of Patent: November 25, 1997Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University SystemInventors: Michael H. Kogut, John R. DeLoach, Larry H. Stanker, Rita B. Moyes, Billy M. Hargis
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Patent number: 5302219Abstract: A process for producing via patterns in a ceramic sheet which includes the steps of forming an array of vias and then selectively filling in at least a portion of the vias with a non-conductive filler material, such as a ceramic, to create a custom via pattern. The process is particularly useful for fabricating grid transformers and ceramic printed circuit boards. The present invention also relates to ceramic devices produced by the process, and a universal tool adapted for carrying out the process.Type: GrantFiled: April 3, 1991Date of Patent: April 12, 1994Assignee: Coors Electronic Package CompanyInventor: Billy M. Hargis