Patents by Inventor Billy R. Martin

Billy R. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inflammation therapy
    Patent number: 9763894
    Abstract: A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid agonist having efficacy at the CB2 receptor but having substantially no efficacy at the CB1 receptor at that amount.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: September 19, 2017
    Assignees: Virginia Commonwealth University, Organix, Inc., Temple University
    Inventors: Billy R. Martin, Mohamad Imad Damaj, Martin W. Adler, Ronald F. Tuma, Ming Zhang, Anu Mahadevan, Raj K. Razdan
  • Inflammation Therapy
    Publication number: 20080139635
    Abstract: A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid agonist having efficacy at the CB2 receptor but having substantially no efficacy at the CB1 receptor at that amount.
    Type: Application
    Filed: December 5, 2007
    Publication date: June 12, 2008
    Inventors: Billy R. Martin, Mohamad Imad Damaj, Martin W. Adler, Ronald F. Tuma, Ming Zhang, Anu Mahadevan, Raj K Razdan
  • Water Soluble Cannabinoids
    Publication number: 20080064679
    Abstract: Water-soluble cannabinoid compounds that are agonists of CB1 and CB2 cannabinoid receptors are provided. The compounds are made water-soluble by derivatization of the alkyl side chain and/or the phenolic hydroxyl group of tetrahydrocannabinol. The water-soluble cannabinoids are useful for the treatment of appetite loss, pain, multiple sclerosis, nausea and vomiting, and epilepsy.
    Type: Application
    Filed: June 23, 2005
    Publication date: March 13, 2008
    Inventors: Billy R. Martin, Raj K. Razdan, Anu Mahadevan
  • Cannabinoids
    Patent number: 7285687
    Abstract: Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: October 23, 2007
    Assignees: Virginia Commonwealth University, Organix Inc.
    Inventors: Billy R. Martin, Raj K. Razdan
  • Sulfonamide cannabinoid agonists and antagonists
    Patent number: 7279500
    Abstract: Cannabinoid agonists and antagonists are provided for use in the treatment of disorders such as acute and chronic pain, inflammation, loss of appetite, convulsions, multiple sclerosis, nausea and vomiting. The cannabinoid agonists and antagonists contain a sulfonamide moiety incorporated into the cannabinoid side chain, and the side chain itself may be saturated or unsaturated.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: October 9, 2007
    Assignee: Virginia Commonwealth University
    Inventors: Billy R. Martin, Raj K. Razdan, Roger G. Pertwee
  • Cannabinoids
    Patent number: 7179800
    Abstract: Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: February 20, 2007
    Assignee: Virginia Commonwealth University
    Inventors: Billy R. Martin, Raj K. Razdan
  • Delta9 tetrahydrocannabinol (delta9 THC) solution metered dose inhalers and methods of use
    Publication number: 20040258622
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 23, 2004
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Novel eicosanoid analgesics
    Publication number: 20040122089
    Abstract: Analogs of andandamide and arvanil have been found to act preferential at CB1 and AR1 receptors, and at receptors other than CB1 and AR1. The analogs provide analgesic effects in vivo, and are useful in pain management. In addition, the analogs may be used as anti-proliferative/anti-tumor agents, vasodilators, and in other applications. Several of the anandamide and arvanil analogs are more potent than anandamide and arvanil.
    Type: Application
    Filed: February 13, 2003
    Publication date: June 24, 2004
    Inventors: Billy R. Martin, Raj K. Razdan, Vincenzo Di Marzo
  • &Dgr;9 tetrahydrocannabinol (&Dgr;9 THC) solution metered dose inhalers and methods of use
    Patent number: 6713048
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: March 30, 2004
    Assignee: Virginia Commonwealth University
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • &Dgr;9 Tetrahydrocannabinol (&Dgr;9 THC) solution metered dose inhaler
    Patent number: 6509005
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: January 21, 2003
    Assignee: Virginia Commonwealth University
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Pyrazole cannabinoid agonist and antagonists
    Patent number: 6509367
    Abstract: Disclosed are pyrazole derivatives of formula I: Where R1, R2, R3, and R4 are defined as in the specification described. These compounds are antagonists of the brain cannabinoid (CB-1) receptors and could be used as active gradients in pharmaceutical preparations to block or inhibit cannabinoid receptors in mammals.
    Type: Grant
    Filed: September 22, 2001
    Date of Patent: January 21, 2003
    Assignees: Virginia Commonwealth University, Organix, Inc.
    Inventors: Billy R. Martin, Raj K. Razdan, Anu Mahadevan
  • Delta9 tetrahydrocannabinol (Delta9 THC) solution metered dose inhalers and methods of use
    Publication number: 20020031480
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy—muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Application
    Filed: September 4, 2001
    Publication date: March 14, 2002
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Compounds and pharmaceutical compositions thereof for eliciting analgesic effects
    Patent number: 6117891
    Abstract: The present invention relates to treatment of pain with a new class of analgesic compounds. More particularly, the present invention relates to a method for reducing pain of a patient involving administering to a patient an effective amount of an aryl substituted olefinic amine compound. In one aspect, the inventive method of reducing pain in a patient involves use of metanicotine compounds as the analgesic agent.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: September 12, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Billy R. Martin, Mohamad I. Damaj
  • Compounds and pharmaceutical compositions thereof for eliciting analgesic effects
    Patent number: 5914337
    Abstract: The present invention relates to treatment of pain with a new class of analgesic compounds. More particularly, the present invention relates to a method for reducing pain of a patient involving administering to a patient an effective amount of an aryl substituted olefinic amine compound. In one aspect, the inventive method of reducing pain in a patient involves use of metanicotine compounds as the analgesic agent.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: June 22, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Billy R. Martin, Mohamad I. Damaj
  • Water soluble derivatives of cannabinoids
    Patent number: 5847128
    Abstract: Water-soluble esters of tetrahydrocannabinoids, which are well-suited for administration in therapeutic aqueous formulations, having following general formula: ##STR1## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a substituent such as a lower alkyl group, and the pharmaceutically acceptable salts of these compounds.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: December 8, 1998
    Assignee: Virginia Commonwealth University
    Inventors: Billy R. Martin, Raj K. Razdan