Patents by Inventor Billy W. Day

Billy W. Day has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury
    Publication number: 20200207691
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Application
    Filed: March 12, 2020
    Publication date: July 2, 2020
    Inventors: Billy W. Day, Neil Hukriede
  • Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
    Patent number: 10626071
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 21, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Neil Hukriede
  • Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
    Patent number: 10233201
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 19, 2019
    Assignee: University of Pittsburg—Of the Commonwealth System of Higher Education
    Inventors: Neil Hukriede, Billy W. Day, Lee A. McDermott
  • Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
    Patent number: 10160705
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: December 25, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Neil Hukriede
  • Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury
    Publication number: 20180312455
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Application
    Filed: April 24, 2018
    Publication date: November 1, 2018
    Inventors: Billy W. Day, Neil Hukriede
  • Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury
    Publication number: 20170320898
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Application
    Filed: May 30, 2017
    Publication date: November 9, 2017
    Inventors: Neil Hukriede, Billy W. Day, Lee A. McDermott
  • Compounds for treating HIV and methods for using the compounds
    Patent number: 9695127
    Abstract: Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: July 4, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Thomas E. Smithgall, Lori Ann Emert-Sedlak, Billy W. Day, Jielu Zhao, Prema Chandrasekhar Iyer
  • Small molecule inhibitors of Dusp6 and uses therefor
    Patent number: 9682919
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: June 20, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
    Patent number: 9670236
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: June 6, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Neil Hukriede, Billy W. Day, Lee A. McDermott
  • Small Molecule Inhibitors of Dusp6 and Uses Therefor
    Publication number: 20160355459
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY
    Publication number: 20160332943
    Abstract: The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high efficiency separations platform applicable to a broad range of separation functions.
    Type: Application
    Filed: February 10, 2012
    Publication date: November 17, 2016
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education, Pittsburgh, PA
    Inventors: Billy W. Day, Neil Hukriede
  • Small molecule inhibitors of Dusp6 and uses therefor
    Patent number: 9439877
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 13, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Pederin and psymberin agents
    Patent number: 9364555
    Abstract: Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: June 14, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Paul Edward Floreancig, Billy W. Day, Shuangyi Wan, Fanghui Wu
  • Small Molecule Inhibitors of Dusp6 and Uses Therefor
    Publication number: 20160113889
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Application
    Filed: July 9, 2015
    Publication date: April 28, 2016
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS
    Publication number: 20150291534
    Abstract: Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity.
    Type: Application
    Filed: November 6, 2013
    Publication date: October 15, 2015
    Inventors: Thomas E. Smithgall, Lori Ann Emert-Sedlak, Billy W. Day, Jielu Zhao, Prema Chandrasekhar Iyer
  • Small molecule inhibitors of Dusp6 and uses therefor
    Patent number: 9127016
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: September 8, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury
    Publication number: 20150246939
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Application
    Filed: October 31, 2013
    Publication date: September 3, 2015
    Inventors: Neil Hukriede, Billy W. Day, Lee A. McDermott
  • PEDERIN AND PSYMBERIN AGENTS
    Publication number: 20140161877
    Abstract: Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin.
    Type: Application
    Filed: July 19, 2012
    Publication date: June 12, 2014
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Paul Edward Floreancig, Billy W. Day, Shuangyi Wan, Fanghui Wu
  • TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
    Publication number: 20140128388
    Abstract: Drug candidates for inhibition of HIV-1 replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-1 viral replication in vitro.
    Type: Application
    Filed: July 31, 2013
    Publication date: May 8, 2014
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Lori Emert-Sedlak, Toshiaki Kodama, Billy W. Day, Weixiang Dai, Ronald P. Trible, Thomas E. Smithgall
  • CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY
    Publication number: 20140081054
    Abstract: The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high efficiency separations platform applicable to a broad range of separation functions.
    Type: Application
    Filed: February 10, 2012
    Publication date: March 20, 2014
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education, Pittsburgh, PA
    Inventors: Billy W. Day, Neil Hukriede