Patents by Inventor Bimal Chakrabarti

Bimal Chakrabarti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9012618
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: April 21, 2015
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • Patent number: 8454972
    Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: June 4, 2013
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GenVec, Inc.
    Inventors: Gary J. Nabel, Ling Xu, Bimal Chakrabarti, Lan Wu, Zhi-yong Yang, Jason G. D. Gall, C. Richter King, Zengguang Wang
  • Patent number: 8323961
    Abstract: The invention provides a composition comprising four adenoviral vectors, each comprising a nucleic acid sequence encoding a clade A HIV Env protein, a clade B HIV Env protein, a clade C HIV Env protein, and a clade B HIV Gag-Pol fusion protein, respectively. The invention also provides a method of inducing an immune response against HIV-1 in an animal comprising administering the composition to the animal.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: December 4, 2012
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GenVex, Inc.
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-Pui Kong, Yue Huang, Zengguang Wang, legal representative, Zhi-Yong Yang, Jason G. D. Gall, C. Richter King
  • Publication number: 20120156239
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Application
    Filed: January 13, 2012
    Publication date: June 21, 2012
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • Patent number: 8101739
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: January 24, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang, Maria Grazia Pau, Jaap Goudsmit, Gary Nabel
  • Publication number: 20110274721
    Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
    Type: Application
    Filed: April 14, 2011
    Publication date: November 10, 2011
    Applicants: GenVec, Inc., The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-Pui Kong, Yue Huang, Zengguang Wang, Zhi-Yong Yang, Jason G.D. Gall, C. Richter King
  • Publication number: 20110200636
    Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
    Type: Application
    Filed: January 20, 2011
    Publication date: August 18, 2011
    Applicants: The USA, as represented by the Secretary, Dept. of Health and Human Services, GenVec, Inc.
    Inventors: Gary J. Nabel, Yue Huang, Zengguang Wang, Ling Xu, Bimal Chakrabarti, Lan Wu, Zhi-yong Yang, Jason G.D. Gall, C. Richter King
  • Patent number: 7947822
    Abstract: The invention provides a composition comprising a pharmaceutically acceptable carrier and six plasmids, each of which encodes an HIV Env, Gag, Pol, or Nef protein. The invention also provides a method of inducing an immune response in an animal using the composition.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: May 24, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-Pui Kong, Yue Huang, Zengguang Wang, legal representative, Zhi-Yong Yang
  • Publication number: 20100111998
    Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single Glade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
    Type: Application
    Filed: January 7, 2010
    Publication date: May 6, 2010
    Applicants: Service
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-pui Kong, Yue Huang, Zengguang Wang, Zhi-yong Yang
  • Patent number: 7666427
    Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: February 23, 2010
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-pui Kong, Yue Huang, Zengguang Wang, legal representative, Zhi-yong Yang
  • Publication number: 20090232841
    Abstract: The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
    Type: Application
    Filed: September 27, 2005
    Publication date: September 17, 2009
    Inventors: Nancy Sullivan, Bimal Chakrabarti, Zhi-Yong Yang
  • Publication number: 20090214588
    Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
    Type: Application
    Filed: July 15, 2005
    Publication date: August 27, 2009
    Inventors: Gary J. Nabel, Yue Huang, Zengguang Wang, Ling Xu, Bimal Chakrabarti, Lan Wu, Zhi-yong Yang, Jason G.D. Gall, C. Richter King
  • Publication number: 20080286306
    Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
    Type: Application
    Filed: June 13, 2007
    Publication date: November 20, 2008
    Inventors: Gary J. Nabel, Bimal Chakrabarti, Wing-pui Kong, Yue Huang, Zhi-yong Yang, Zengguang Wang
  • Publication number: 20060275897
    Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
    Type: Application
    Filed: March 15, 2006
    Publication date: December 7, 2006
    Inventors: Gary Nabel, Bimal Chakrabarti, Wing-pui Kong, Yue Huang, Zengguang Wang, Zhi-yong Yang