Abstract: A system is disclosed. A node may include a resource. A lock manager may include storage for a data structure for a lock. The data structure may include a first identifier for the resource, a second identifier for an application, and a status for the lock.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: A system and method of using metrics to control throttling and swapping in a message processing system is provided. A workload status of a message processing system is determined, and the system polls for a new message according to the workload status. The message processing system identifies a blocked instance and calculates an expected idle time for the blocked instance. The system dehydrates the blocked instance if the expected idle time exceeds a predetermined threshold.

Abstract: A system and method of using metrics to control throttling and swapping in a message processing system is provided. A workload status of a message processing system is determined, and the system polls for a new message according to the workload status. The message processing system identifies a blocked instance and calculates an expected idle time for the blocked instance. The system dehydrates the blocked instance if the expected idle time exceeds a predetermined threshold.

Abstract: A system and method of using metrics to control throttling and swapping in a message processing system is provided. A workload status of a message processing system is determined, and the system polls for a new message according to the workload status. The message processing system identifies a blocked instance and calculates an expected idle time for the blocked instance. The system dehydrates the blocked instance if the expected idle time exceeds a predetermined threshold.

Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogs, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.

Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.

Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.

Abstract: A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.

Abstract: Described are embodiments directed at providing resilient services using architectures that have a number of failover features including the ability to handle failover of an entire data center. Embodiments include a first server pool at a first data center that provides client communication services. The first server pool is backed up by a second server pool that is located in a different data center. Additionally, the first server pool serves as a backup for the second server pool. The two server pools thus engage in replication of user information that allows each of them to serve as a backup for the other. In the event that one of the data centers fails, requests are rerouted to the backup server pool.

Abstract: A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.

Abstract: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as Pichia.

Abstract: A method of making a wear and fatigue resistant component of a power tool (e.g., a clutch) includes providing a quantity of base steel and a quantity of alloying elements to be added to the base steel to form a desired alloyed grade of steel. The base steel and alloying elements are combined and melted to produce a molten alloyed steel (e.g., SAE 9310 or AISI M2). The molten alloyed steel is cast using a near-net-shape investment casting process to form a component of a power tool. An edge of the component is pre-radiused. and the component is case hardened after the edge of the component has been pre-radiused. In one implementation, the component is a clutch that has a lifespan of at least twice a lifespan of a second clutch that has not been pre-radiused prior to case hardening.

Abstract: A system and method of using metrics to control throttling and swapping in a message processing system is provided. A workload status of a message processing system is determined, and the system polls for a new message according to the workload status. The message processing system identifies a blocked instance and calculates an expected idle time for the blocked instance. The system dehydrates the blocked instance if the expected idle time exceeds a predetermined threshold.

Abstract: A system and method of using metrics to control throttling and swapping in a message processing system is provided. A workload status of a message processing system is determined, and the system polls for a new message according to the workload status. The message processing system identifies a blocked instance and calculates an expected idle time for the blocked instance. The system dehydrates the blocked instance if the expected idle time exceeds a predetermined threshold.

Abstract: An error-handling framework is provided for business process transactions. The error-handling framework facilitates coordination of the invocation of exception and compensation handlers in response to errors. The error-handling framework includes support for custom ordering of compensation actions, data flow into and out of compensation actions, and management of the process state visible to compensation actions.

Abstract: A process for manufacturing highly wear and fatigue resistant steel components for power tools includes melting and mixing together a readily available base steel and alloying elements. The molten steel is cast into near-net-shape in an investment casting process. This method is cost competitive with forming the same component from steel with fewer alloying elements. In particular, clutch plates for a drill/driver or screw gun can be formed in this manner from a steel containing relatively large amounts of nickel and chromium, such as SAE 9310 steel, or from a steel containing a relatively large total amount of molybdenum and tungsten, such as AISI M2 steel.

Abstract: An error-handling framework is provided for business process transactions. The error-handling framework facilitates coordination of the invocation of exception and compensation handlers in response to errors. The error-handling framework includes support for custom ordering of compensation actions, data flow into and out of compensation actions, and management of the process state visible to compensation actions.

Abstract: A system and method facilitating business process(es) employing a correlation set is provided. The invention includes a system for sending message(s) having a data retrieval component and a service component. The data retrieval provides an output to the service component based on a schema and a business process type. The service component generates a message having a correlation set based on the output of the data retrieval component. To initiate a business process, the service component generates an activation message and the correlation set, the correlation set uniquely identifying the business process.

Abstract: Systems and methodologies are disclosed to facilitate for routing messages in a communications framework, which can include one or more computers. Determinations as to whether and where to route messages are based at least in part upon the content of messages. Services interested in receiving messages specify one or more subscriptions, which are employed to make routing decisions for messages. The subscriptions are evaluated relative to messages, and more particularly content based message properties of respective messages, to determine whether and where to route messages.