Publication number: 20260315491
Abstract: The present invention provides compounds of formula (I): or a pharmaceutically acceptable salt, geometric isomer, enantiomer, diastereomer, racemate, prodrug, solvate, hydrate thereof or any foregoing being isotope-labeled, wherein ring A, ring B, Y, L, R1, R2, R3, RA, RB, m, n, p and q are as disclosed in the specification. Also provided are pharmaceutical compositions and methods for use as MTA cooperative inhibitors of PRMT5. The invention further provides a method for preparing the compound.
Type:
Application
Filed:
April 26, 2024
Publication date:
October 15, 2026
Applicant:
PHARMAENGINE, INC.
Inventors:
CHENG-HAO LIU, LONG-ZHI LIN, HONG-REN WANG, JIANFENG MOU, XINLI DUAN, QINGFANG YU, YAYU CHEN, TONG WANG, GUANGPING DONG, BIN CHEN, PEIYU ZHANG