Abstract: The present disclosure provides a compound as an NLRP3 inhibitor, which has a novel bicyclic fused ring core. The present disclosure further relates to a preparation method thereof, a pharmaceutical composition and a drug containing the same, and its use in the treatment of diseases and disorders mediated by NLRP3.

Abstract: A light source, comprising: an excitation light source and a wavelength conversion apparatus. The excitation light source comprises a housing, a laser chip, and a light beam guiding element. The housing forms a packaging cavity. The packaging cavity is provided with a light outlet. The wavelength conversion apparatus is spaced apart from the housing and corresponds to the light outlet. The wavelength conversion apparatus and the excitation light source are separately arranged, and the housing of the excitation light source and the wavelength conversion apparatus are spaced apart, so that the wavelength conversion apparatus can be easily maintained and replaced, so as to avoid waste by discarding the entire light source.

Abstract: The present application relates to an indolone derivative having an IRAK4 inhibitory activity as represented by formula (I), a preparation method therefor and the use thereof, and further relates to a compound capable of inhibiting and degrading the IRAK4 protein and a pharmaceutical composition comprising the indolone derivative or the compound capable of inhibiting and degrading the IRAK4 protein.

Abstract: A self-locking mechanism for a folding sofa is provided. The self-locking mechanism includes a link assembly, a self-locking rivet, and a limit rotating rod, where the link assembly includes one end pivoted to a front sofa cushion and the other end pivoted to a fixed base frame of a sofa frame; the front sofa cushion is folded and stored on a rear sofa cushion inside the sofa frame or unfolded at one side of the rear sofa cushion through the linkage of the link assembly; the self-locking rivet is located on the link assembly; the limit rotating rod is movably provided on the front sofa cushion; one end of the limit rotating rod is provided with an arc-shaped hook corresponding to the self-locking rivet; and when the front sofa cushion is unfolded at one side of the rear sofa cushion, the link assembly drives the self-locking rivet to slide.

Abstract: Provided in the present disclosure are a supporting assembly and an assembly method therefor, and a light source device. The supporting assembly may comprise a supporting member and a light guiding element, wherein the light guiding element can be disposed at the position of a mounting surface of the supporting member corresponding to a mounting hole. When a second bottom surface of the light guiding element is in a state in which the pressure of air in the mounting hole is less than the pressure of air outside the mounting hole, the light guiding element can be pre-fixed on the supporting member, and then the supporting member and the light guiding element are fixed by means of dispensing glue, such that the precision of the positional arrangement of the light guiding element is improved, and thus the reflection precision of the light guiding element is improved.

Abstract: A knowledge graph-driven groundwater-oriented method for building risk warning includes: extracting a relationship quadruple between groundwater level change and building structure change based on collected groundwater level data and building data; creating a cross-domain knowledge graph based on the relationship quadruple, and associating two different fields; updating the cross-domain knowledge graph in real time to realize the building risk warning caused by groundwater level changes. The risk warning is based on the causal relationship reflected in the factual data, making the risk warning more accurate, which can effectively solve the problem of the lack of risk warning system for buildings due to groundwater level changes in the related art.

Abstract: The present application relates to a novel IRAK4 inhibitor of formula (I) and a compound for inhibiting and degrading IRAK4 protein, a preparation method therefor and use thereof, and also relates to a pharmaceutical composition comprising the IRAK4 inhibitor or the compound for inhibiting and degrading IRAK4 protein.

Abstract: Provided are a compound or an enantiomer, diastereoisomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, or metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound, or prodrug thereof, as well as an application thereof in the treatment of a CRBN-mediated disease or disorder.

Abstract: A silent lock, comprising a lock shell, a latch bolt, a first elastic member and a second elastic member. The latch bolt is slidably connected to the lock shell, the latch bolt has a first retracted position located inside the lock shell and a first extended position at least partially protruding out of the lock shell, and the first elastic member connects the latch bolt and the lock shell and presses the latch bolt toward the first extended position; the second elastic member connects the latch bolt and the lock shell and presses the latch bolt toward the first retracted position; and when the latch bolt (2) is in the first extended position, the elastic force of the first elastic member is equal to the elastic force of the second elastic member.

Abstract: The present invention discloses a tribochemical in-situ characterization device and application. The tribochemical in-situ characterization device includes an ATR support member, an ATR crystal and a heating module, a sample groove is formed in the ATR support member, a light path channel communicated with a bottom of the sample groove is formed in the ATR support member, the ATR crystal is mounted in the light path channel, and the heating module is arranged on a lower end surface of the ATR crystal. The tribochemical in-situ characterization device further includes a mechanical friction device that is arranged in the sample groove and above the ATR crystal. The mechanical friction device includes a sliding rail fixed to a top of the ATR support member, an adapter block slidably arranged on the sliding rail and a grinding head detachably fixed to a lower end of the adapter block.

Abstract: The invention, which relates to a liquid-carrying roller for wet etching and a wet etching method, belongs to the technical field of solar cell manufacturing, and solves the problem of abnormal roller levelness in a process of manufacturing a solar cell in the prior art. The liquid-carrying roller for wet etching of the invention comprises a first end shaft, a second end shaft, and a liquid-carrying shaft, the first end shaft and the second end shaft being located at both ends of the liquid-carrying shaft, respectively, the first end shaft, the second end shaft and the liquid-carrying shaft being arranged concentrically, and the diameters of the first end shaft and the second end shaft being both adjustable.

Abstract: Disclosed is a deep underground hydrogen storage structure and its construction method. The structure comprises a concrete lining layer, a hydrogen barrier layer, a connecting framework, and multiple supporting arms; multiple supporting arms are spaced apart around the perimeter of the chamber, with each supporting arm having a connection end and a geotechnical end, and a grouting channel that connects the connection end and the geotechnical end. The grouting channel has a grout inlet at the connection end and a grouting port at the geotechnical end. This disclosure enables grouting reinforcement of the rock and soil layers around the geotechnical end through the grouting port of the grouting channel, achieving coordinated stress sharing between the deep underground hydrogen storage structure and the surrounding rock and soil layers, and significantly improving the safety performance of the deep underground hydrogen storage structure.

Abstract: Provided are a compound for recovering a p53 mutation function and use thereof, particularly relating to a compound represented by Formula M, or an enantiomer, a diastereomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a crystal form, a nitrogen oxide, a metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug of the compound.

Abstract: A self-locking mechanism and a folding sofa are provided. The self-locking mechanism includes a support member, a locking member, a drive member and a switch member. The support member has a first end and a second end opposite to each other. The locking member has a first connection portion and a locking portion, and the first connection portion of the locking member is pivotally connected to the first end of the support member. One end of the drive member is pivotally connected to the first connection portion of the locking member. The switch member has a second connection portion and a switch portion, where the second connection portion of the switch member is pivotally connected to the second end of the support member and the other end of the drive member.

Abstract: Perovskite optoelectronic devices, e.g., solar cells, are provided, which comprise a perovskite layer comprising a perovskite; and chemical passivating ligands bound to the perovskite of the perovskite layer, wherein the chemical passivating ligands comprise a thioether group, —SR?, wherein R? is an alkyl group.

Abstract: A laser light combining apparatus. The laser light combining apparatus comprises a light splitting element and a wavelength conversion element. The light splitting element is used for reflecting a portion of a laser incident at the side of the light splitting element facing away from the wavelength conversion element, so as to form a first wavelength beam, and used for transmitting the unreflected portion of the laser to the wavelength conversion element the wavelength conversion element is used for performing wavelength conversion on the unreflected portion of the laser to form a second wavelength beam, and reflecting the second wavelength beam to the light splitting element, so that the second wavelength beam and the first wavelength beam form combined light, where the divergence angle of the first wavelength beam and the divergence angle of the second wavelength beam are both greater than the divergence angle of the laser.

Abstract: An electronic device testing method and an electronic device testing system are provided. The method includes following steps. A display image displayed by an electronic device under test is captured through a camera device. By analyzing the display image displayed by the electronic device under test, an automatic control command is determined. The automation control command is sent to the electronic device under test or an external execution device to control the electronic device under test to execute a target operation corresponding to the automation control command. While the electronic device under test performs the target operation, a device testing procedure of the electronic device under test is executed.

Abstract: The present application provides a compound as shown in formula (0), a pharmaceutical composition containing same, a synthesis method therefore and a use thereof. The compound of the present application can significantly reduce the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that the protein in the cells tends to be synthesized normally, providing more possible drugs for ISR pathway-mediated diseases or condition eIF2B-related diseases, and/or diseases related to regulation of the activity or level of eIF2B activity or level, and regulation of the activity or level of the eIF2 pathway or ISR pathway.