Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CR1 or N; Y is —(CR5R5)m—; Z is —(CR5R5)n—; and q, R1, R2, R3, R4, R6, R7, R8, R9, and R10 are defined herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Compositions comprising endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSC)that over-express Sirtuin 1 (SIRT1) are disclosed. Further disclosed are methods of preparation of the compositions, and methods for treating a subject comprising administering transplatanbe cells, tissue, or organ comprising the iPSC-derived ECs overexpressing SIRT1, as well as methods of testing an agent for therapeutic efficacy and toxicity using the compositions.

Abstract: One or more small-scale maps are generated automatically and directly from a single large-scale map or database. A subset of geographic features to be represented in the small-scale map is selected based on the scaling law. The geographic features in the subset are determined based on topological connectivity, size, bend size or point density characterizing the geographic features, so the subset includes the larger or more connected or with higher density among the geographic features.

Abstract: A smear staining machine and a smearing control method and device thereof. The viscosity of the test sample is used for guiding the configuration of at least one smearing parameter. Because the viscosity of the test sample presents multiple influences of many effecting parameters, it is more suitable for presenting the characteristics of the test sample. Therefore, a better smearing effect could be acquired by referring the viscosity of the test sample to get the smearing parameter.

Abstract: A smart, integrated charging device for electric vehicles is provided. The alternating current input module is connected to an electricity metering module via an alternating current input switch. The charging module is connected to the electricity metering module via a module alternating current switch and an alternating current bus, and is connected to an output monitoring module via a direct current bus. The output monitoring module is connected to the monitoring and general control module (13). The direct current output module is connected to the output monitoring module (4) via a direct current output switch. The lightning protection module is connected to the direct current bus. The charging module utilizes smart power combination and multiple output coordination to enable output with current sharing and the automatic balance control technology.

Abstract: Based on information associated with users, a social networking system recommends one or more groups for a target user to join or to create. Characteristics of the target user, characteristics of users connected to the target user, characteristics of candidate groups in the social networking system may be used to identify groups for recommendation. The social networking system may provide questions to the target user and recommend a group to the target user based on received answers to the questions. For example, the answers to the provided question identify one or more characteristics of the target user, which are used to select a group for recommendation. Additionally, the social networking system may recommend additional users for the target user to add or invite to a group based on characteristics of the target user, the additional users, and/or the group.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: The present invention discloses a test platform for high-frequency cable, comprising conductive contacts and clamps for pressing a conductor of the cable on the conductive contact, and comprising a splitter seat, which comprises a top surface and a plurality of varied sides, the conductive contacts are respectively arranged on the sides, the clamps are arranged at a peripheral of the splitter seat and is opposite to the conductive contact, the splitter seat is further provided with a splitter channel, and the splitter channel slantingly connects the top surface to the sides. The present invention adopts a splitter seat with a polyhedral structure, which may shorten the stripped length, and prevent for vertically bending the core, thereby reducing the damage to the cable structure to the greatest extent, and greatly increasing the test frequency.

Abstract: A woofer speaker is provided, comprising a woofer speaker unit, a first sealing pad, a second sealing pad and a housing. The first sealing pad is fixed closely with the outer edge of the housing; the woofer speaker unit is fixed and sealed within the housing by the first sealing pad, and the second sealing pad is located between the woofer speaker unit and the housing; a sound hole is provided on the housing, and the shape and size of the sound hole correspond to those of the woofer speaker; and the terminal installation plane is the rear cover of the woofer speaker, and together with the housing forms the rear sound cavity of the woofer speaker through the first sealing pad. The cavity of the woofer speaker provided by the invention and the installation terminal applying the woofer speaker resolve the rear cover vibration problem of ultra-thin woofer speakers.

Abstract: Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.

Abstract: Described are ROR? modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders.

Abstract: Method and apparatus for reducing distortion echo are provided. K-path amplification and pre-distortion process are performed to the downlink reference signal to obtain K-path pre-distorted signals. Afterwards, filtering is performed using the self-adaptive filters which correspond to the downlink reference signal x(t) and the K-path pre-distorted signals to obtain the filtering signals. Error signals are obtained by calculating differences between the target signal and each of the filtering signals. The minimum-value fusion process is performed to the error signals to obtain the residual signal which is then output as the final self-adaptive echo cancellation. In embodiments of the present disclosure, the residual signal is relatively small as the minimum-value fusion process is performed to the error signals. That is to say, echo loss is relatively great. Therefore, the method may provide echo loss with high amplitude under a situation that a speaker has relatively serious distortion.

Abstract: A method of switching between noise reduction modes in multi-microphone mobile devices may include receiving a first sound signal at a first sound receiver and receiving a second sound signal at a second sound receiver. The method may also include determining a first power value associated with the first sound signal and determining a second power value associated with the second sound signal. The method may additionally include comparing the first power value to the second power value and switching between a single-microphone noise reduction mode and a dual-microphone noise reduction mode based on the comparison.

Abstract: Described are ROR? modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders.

Abstract: The present invention discloses a test platform for high-frequency cable, comprising conductive contacts and clamps for pressing a conductor of the cable on the conductive contact, and comprising a splitter seat, which comprises a top surface and a plurality of varied sides, the conductive contacts are respectively arranged on the sides, the clamps are arranged at a peripheral of the splitter seat and is opposite to the conductive contact, the splitter seat is further provided with a splitter channel, and the splitter channel slantingly connects the top surface to the sides. The present invention adopts a splitter seat with a polyhedral structure, which may shorten the stripped length, and prevent for vertically bending the core, thereby reducing the damage to the cable structure to the greatest extent, and greatly increasing the test frequency.

Abstract: Described are ROR? modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders.

Abstract: The embodiments of the present disclosure provide a method and an apparatus for reducing an echo, which apply a first stage adaptive filter to a downlink reference signal to obtain a first stage filtered signal and a first error signal; after performing a K-path gain process and a K-path pre-distortion process to the downlink reference signal, apply the at least one second stage adaptive filter to a K-path pre-distorted signal to obtain a second stage filtered signal and a second error signal; and perform a minimum value fusion process to the first error signal and the second error signal so as to obtain a residue signal, which is considered as a final output of adaptive echo cancellation. Accordingly, the present disclosure realizes steadily providing a relatively high echo loss under a circumstance that a speaker suffers a relatively great distortion.