Abstract: This disclosure discloses a method and system for predicting disease quantification parameters for an anatomical structure. The method includes extracting a centerline structure based on a medical image. The method further includes predicting the disease quantification parameter for each sampling point on the extracted centerline structure by using a GNN, with each node corresponds to a sampling point on the extracted centerline structure and each edge corresponds to a spatial constraint relationship between the sampling points. For each node, a local feature is extracted based on the image patch for the corresponding sampling point by using a local feature encoder, and a global feature is extracted by using a global feature encoder based on a set of image patches for a set of sampling points, which include the corresponding sampling point and have a spatial constraint relationship defined by the centerline structure.

Abstract: The present disclosure relates to a method and a system for generating anatomical labels of an anatomical structure. The method includes receiving an anatomical structure with an extracted centerline, or a medical image containing the anatomical structure with the extracted centerline; and predicting the anatomical labels of the anatomical structure based on the centerline of the anatomical structure, by utilizing a trained deep learning network. The deep learning network includes a branched network, a Graph Neural Network, a Recurrent Neural Network and a Probability Graph Model, which are connected sequentially in series. The branched network includes at least two branch networks in parallel. The method in the disclosure can automatically generate the anatomical labels of the whole anatomical structure in medical image end to end and provide high prediction accuracy and reliability.

Abstract: Embodiments of the disclosure provide methods and systems for joint abnormality detection and physiological condition estimation from a medical image. The exemplary method may include receiving, by at least one processor, the medical image acquired by an image acquisition device. The medical image includes an anatomical structure. The method may further include applying, by the at least one processor, a joint learning model to determine an abnormality condition and a physiological parameter of the anatomical structure jointly based on the medical image. The joint learning model satisfies a predetermined constraint relationship between the abnormality condition and the physiological parameter.

Abstract: A method for inspecting a critical dimension may include providing a substrate, applying a photoresist on the substrate, variably irradiating a dose of light onto the photoresist, performing a photo process to develop the photoresist to form a photoresist pattern, performing an etching process using the photoresist pattern as an etching mask to form a plurality of patterns, measuring a width of each of the plurality of patterns and a spacing between adjacent ones of the plurality of patterns, and identifying a cause of a defect in the photo process based on the measured width and the measured spacing.

Abstract: A preparation method of a composite anode material of micrometer-sized carbon-coated silicon and carbon includes: subjecting micrometer-sized silicon particles to a chemical vapor deposition reaction under a gas atmosphere containing carbon to obtain carbon-coated first micrometer-sized silicon particles; dispersing the carbon-coated first micrometer-sized silicon particles in a first mixed solvent to obtain a dispersed solution; adding alkali into the dispersed solution and heating the dispersed solution to obtain carbon-coated second micrometer-sized silicon particles; dispersing the carbon-coated second micrometer-sized silicon particles and graphene oxide in a second mixed solvent that are subjected to a hydrothermal reaction to obtain a composite hydrogel of reduced graphene oxide, silicon, and carbon; and heating the hydrogel to obtain the composite anode material.

Abstract: Embodiments of the disclosure provide methods and systems for representation learning from a biomedical image with a sparse convolution. The exemplary system may include a communication interface configured to receive the biomedical image acquired by an image acquisition device. The system may further include at least one processor, configured to extract a structure of interest from the biomedical image. The at least one processor is also configured to generate sparse data representing the structure of interest and input features corresponding to the sparse data. The at least one processor is further configured to apply a sparse-convolution-based model to the biomedical image, the sparse data, and the input features to generate a biomedical processing result for the biomedical image. The sparse-convolution-based model performs one or more neural network operations including the sparse convolution on the sparse data and the input features.

Abstract: This disclosure discloses a method and system for predicting disease quantification parameters for an anatomical structure. The method includes extracting a centerline structure based on a medical image. The method further includes predicting the disease quantification parameter for each sampling point on the extracted centerline structure by using a GNN, with each node corresponds to a sampling point on the extracted centerline structure and each edge corresponds to a spatial constraint relationship between the sampling points. For each node, a local feature is extracted based on the image patch for the corresponding sampling point by using a local feature encoder, and a global feature is extracted by using a global feature encoder based on a set of image patches for a set of sampling points, which include the corresponding sampling point and have a spatial constraint relationship defined by the centerline structure.

Abstract: This disclosure discloses a method for analyzing clinical data. The Method includes extracting a first feature information by applying a neural network to the clinical data; predicting a disease status related parameter by applying a regression model to the extracted first feature information; generating a second feature information based on the extracted first feature information and the disease status related parameter; and predicting a disease status classification result by applying a classification model to the second feature information. The method can improve the prediction accuracy and the diagnosis efficiency of doctors.

Abstract: The present disclosure relates to a method and a system for generating anatomical labels of an anatomical structure. The method includes receiving an anatomical structure with an extracted centerline, or a medical image containing the anatomical structure with the extracted centerline; and predicting the anatomical labels of the anatomical structure based on the centerline of the anatomical structure, by utilizing a trained deep learning network. The deep learning network includes a branched network, a Graph Neural Network, a Recurrent Neural Network and a Probability Graph Model, which are connected sequentially in series. The branched network includes at least two branch networks in parallel. The method in the disclosure can automatically generate the anatomical labels of the whole anatomical structure in medical image end to end and provide high prediction accuracy and reliability.

Abstract: The disclosure relates to a system and method for predicting physiological-related parameters based on a medical image. The method includes receiving a medical image acquired by an image acquisition device and predicting a sequence of physiological-related parameters at a sequence of positions and simultaneously estimating an uncertainty level of the predicted sequence of physiological parameters from the medical image by using a sequential learning model. The sequential learning model is trained to minimize a loss function associated with the uncertainty level. The method not only provides predictions but also the corresponding uncertainty estimations by using sequential learning model(s), thus improving the transparency and explainability of the sequential learning model.

Abstract: The present disclosure relates to training methods for a machine learning model for physiological analysis. The training method may include receiving training data including a first dataset of labeled data of a physiological-related parameter and a second dataset of weakly-labeled data of the physiological-related parameter. The training method further includes training, by at least one processor, an initial machine learning model using the first dataset, and applying, by the at least one processor, the initial machine learning model to the second dataset to generate a third dataset of pseudo-labeled data of the physiological-related parameter. The training method also includes training, by the at least one processor, the machine learning model based on the first dataset and the third dataset, and providing the trained machine learning model for predicting the physiological-related parameter.

Abstract: Embodiments of the disclosure provide methods and systems for joint abnormality detection and physiological condition estimation from a medical image. The exemplary method may include receiving, by at least one processor, the medical image acquired by an image acquisition device. The medical image includes an anatomical structure. The method may further include applying, by the at least one processor, a joint learning model to determine an abnormality condition and a physiological parameter of the anatomical structure jointly based on the medical image. The joint learning model satisfies a predetermined constraint relationship between the abnormality condition and the physiological parameter.

Abstract: Embodiments of the disclosure provide methods and systems for disease condition prediction from images of a patient. The system may include a communication interface configured to receive a sequence of images acquired of the patient by an image acquisition device. The sequence of images are acquired at a sequence of prior time points during progression of a disease. The system may include a processor, configured to determine regions of interest based on the sequence of images. The processor applies a progressive condition prediction network to the regions of interest to predict a level of disease progression at a future time point during the progression of the disease. The progressive condition prediction network predicts the level of disease progression based on the regions of interest and disease conditions at the sequence of prior time points. The processor further provides a diagnostic output based on the predicted level of disease progression.

Abstract: Embodiments of the disclosure provide methods and systems for determining a disease condition from a 3D image of a patient. The exemplary system may include a communication interface configured to receive the 3D image acquired of the patient by an image acquisition device. The system may further include a processor, configured to determine a 3D region of interest from the 3D image and apply a detection network to the 3D region of interest to determine the disease condition and a severity of the disease condition. The detection network is a multi-task learning network that determines the disease condition based on one or more lesion masks determined from the 3D region of interest and determines the severity of the disease condition from the 3D region of interest. The processor is further configured to provide a diagnostic output based on the disease condition and the severity of the disease condition.

Abstract: The disclosure relates to a method and device for predicting a physical parameter based on input physical information, and medium. The method may include predicting, by a processor, an intermediate variable based on the input physical information with an intermediate sub-model, which incorporates a constraint on the intermediate variable according to prior information of the physical parameter. The method may also include transforming, by the processor, the intermediate variable predicted by the intermediate sub-model to the physical parameter with a transformation sub-model.

Abstract: Embodiments of the disclosure provide methods and systems for predicting a disease condition from images of a patient. The exemplary system may include a communication interface configured to receive a sequence of images acquired of the patient by an image acquisition device. The sequence of images are acquired at a sequence of prior time points during progression of a disease. The system may further include at least one processor, configured to determine regions of interest corresponding to the sequence of prior time points based on the sequence of images. The at least one processor also applies a progressive condition prediction network to the regions of interest to predict a disease condition at a future time point during the progression of the disease. The progressive condition prediction network includes a forward path for predicting the disease condition based on the regions of interest and disease conditions at the sequence of prior time points.

Abstract: Embodiments of the disclosure provide methods and systems for determining a disease condition from a 3D image of a patient. The exemplary system may include a communication interface configured to receive the 3D image acquired of the patient by an image acquisition device. The system may further include at least one processor, configured to determine a 3D region of interest from the 3D image and apply a detection network to the 3D region of interest to determine the disease condition and a severity of the disease condition. The detection network is a multi-task learning network that includes a first task branch and a second task branch, and the first task branch determines the disease condition and the second task branch determines the severity of the disease condition in a single forward pass. The at least one processor is further configured to provide a diagnostic output based on the determined the disease condition and severity of the disease condition.

Abstract: Embodiments of the disclosure provide methods and systems for detecting COVID-19 from a lung image of a patient. The exemplary system may include a communication interface configured to receive the lung image acquired of the patient's lung by an image acquisition device. The system may further include at least one processor, configured to determine a region of interest comprising the lung from the lung image and apply a COVID-19 detection network to the region of interest to determine a condition of the lung. The COVID-19 detection network is a multi-class classification learning network that labels the region of interest as one of COVID-19, non-COVID-19 pneumonia, non-pneumonia abnormal, or normal. The at least one processor is further configured to provide a diagnostic output based on the determined condition of the lung.

Abstract: Embodiments of the disclosure provide systems and methods for detecting cancer metastasis in a whole-slide image. The system may include a communication interface configured to receive the whole-slide image and a learning model. The whole-slide image is acquired by an image acquisition device. The system may also include a memory configured to store a plurality of tiles derived from the whole-slide image in a queue. The system may further include at least one processor, configured to apply the learning model to at least two tiles stored in the queue in parallel to obtain detection maps each corresponding to a tile, and detect the cancer metastasis based on the detection maps.