Abstract: The present disclosure relates generally to compositions and methods useful for the production of engineered antibodies having (i) multiple antigen-binding specificities and (ii) Fc regions that have been modified to promote heterodimer formation between heavy chains from antibodies with different specificities. Also provided are recombinant cells, recombinant nucleic acids encoding such engineered antibodies, as well as pharmaceutical compositions containing same.

Abstract: A pneumatic compression device for popliteal cyst includes an elastic band, two ends of a side of the elastic band are respectively detachably connected to two ends of a side of a fixing band via hook-and-loop fasteners, multiple inflatable bags are installed inside the fixing band, a magnetic sheet is installed on another side of the fixing band, first connecting tubes are fixedly connected to the side of the fixing band, an end of each of the first connecting tubes extending into the fixing band is in communication with a corresponding one of the inflatable bags, and another end of one of the first connecting tubes away from the inflatable bags is detachably connected to a control assembly.

Abstract: The present disclosure relates to the technical field of biological detection, and in particular, to a two-color sequencing method and a kit thereof. Through the optimization of the concentration ratios of the reaction substances and the reaction parameters, the present disclosure develops a two-color sequencing method suitable for a single-molecule sequencing platform. The two-color sequencing method is used for single-molecule sequencing, and is beneficial for reducing error rate, and improving sequencing quality.

Abstract: Efflorescence resistance of concrete blocks is enhanced through the use of glass powder in the concrete composition. The glass powder permits a reduction in the cement content; the glass powder also creates a pozzolanic reaction to change the free calcium ions in calcium hydroxide to calcium silicate to fix the calcium ions inside concrete. The composition includes cementitious binding material of ordinary Portland cement, fly ash, calcium sulfoaluminate cement, ground-granulated blast-furnace slag in an amount from 20 to 25 wt. %. Coarse aggregate is provided from 10 to 15 wt. percent. Fine aggregate is from 32 to 39 wt. %. The composition further includes glass powder having a diameter of less than approximately 75 microns in an amount from 17 to 23 wt. %. Water is present in an amount from 6 to 9 wt. %. The dry density of formed paving blocks is 1800-2200 kg/m3.

Abstract: A smart gas emergency gas supply equipment is provided. The smart gas emergency gas supply equipment may be an emergency vehicle including a skid-mounted vehicle, a gas storage tank, an extensible pipeline group, a pressure regulating device, a gasification device, and a control module. The control module may be configured to determine, based on an emergency gas supply plan of the smart gas emergency gas supply device, operating parameters of the pressure regulating device and the gasification device. The emergency gas supply plan at least includes a gas source selection plan and a gas demand, the gas source selection plan may at least include a gas pipeline network crossover and a gas tank direct supply.

Abstract: A geological advance detection method and system for high-temperature heat damage in tunnels based on thermal source inversion. The geological advance detection method may include: collecting temperature data by using a “rock wall+borehole” multi-view joint observation; extracting collected two-type temperature data to form a new sequence; performing inversion interpretation on the sequence; constructing a thermal source inversion objective function and an inversion equation to solve the inversion equation; based on the solution results, forming a thermal source and temperature field image for high-temperature heat damage detection within the survey area; and, according to the thermal source and temperature field image, a cooling execution scheme is generated by a targeted cooling system to form a closed-loop cooling control and ensures safety of tunnel construction.

Abstract: Embodiments of the disclosure include methods and compostions in which NK cells are modified by the hand of man to express a heterologous a) polypeptide comprising a CD16 Fc binding domain, b) a T Cell Receptor (TCR, e.g., an invariant T Cell Receptor (iTCR), and c) a CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively (with monospecific, bispecific, or multi-specific antibodies, that may have modified or non-modified Fc domains.

Abstract: Disclosed is an IoT system for the control of a smart gas pressure regulation station, comprising: a smart gas user platform, a smart gas service platform, a smart gas equipment management platform, a smart gas sensor network platform, and a smart gas object platform. The smart gas object platform obtains calorific value data of gas and a first pressure regulation parameter, and transmits the calorific value data of gas and the first pressure regulation parameter to the smart gas equipment management platform. The first pressure regulation parameter reflects current pressure regulation data. The smart gas equipment management platform adjusts the first pressure regulation parameter; determines a second pressure regulation parameter; and sends updated pressure regulation data. The smart gas service platform sends the updated pressure regulation data to the smart gas user platform. The smart gas sensor network platform is configured to send the updated pressure regulation data.

Abstract: An integrated diamond manifold microchannel heat sink structure and a manufacturing method thereof are provided. The heat sink structure includes a microchannel structure, a manifold structure and a manifold plate. The manifold structure and microchannel structure are integrated on a diamond substrate. The microchannel structure is connected to the manifold structure, and a microchannel structure surface is sealed. The manifold structure is connected to the manifold plate. The manifold plate is defined with flow-guiding structures penetrating therethrough. The heat sink structure features fewer heterogeneous interfaces. During fabrication, the manifold structure and microchannel structure are fabricated on two opposite sides of the diamond substrate using an ultraviolet nanosecond laser processing system, followed by epitaxial lateral growth of the diamond on the microchannel structure surface via microwave plasma chemical vapor deposition until tops of microchannels are sealed.

Abstract: Provided are a single-crystal diamond microchannel without an internal modified area, and a manufacturing method thereof. The manufacturing method includes: focusing a laser focus on a preset depth position of a target microchannel, and subjecting a bottom area of a side wall of the microchannel to selective induction to form a modified layer; subjecting the microchannel to layer-by-layer scanning, and processing and forming along a preset microchannel path to form a microchannel; and subjecting a resulting processed and formed microchannel to high-temperature oxidation to remove the modified layer in the microchannel, and cleaning and drying to obtain the diamond microchannel without the internal modified structure.

Abstract: The present invention provides a power supply circuit and power supply chip. The power supply circuit includes a logic sub-circuit and a drive sub-circuit. The drive sub-circuit is configured to drive a power transistor and is connected in series with the logic sub-circuit so that the two commonly share at least part of a current. With this arrangement, the series-connection power supply path allows for current sharing between the logic and drive sub-circuits, which can significantly reduce the chip's inherent circuit losses. Moreover, this optimizes the chip from the perspective of circuit structure, lowering its own power consumption. In some embodiments of the invention, the series-connection-based design is adapted to various scenarios, achieving additional improvements in reliability and practicality.

Abstract: A hydroelectric power generation device and a power generation method based on an axial-flow hydraulic turbine are provided. The hydroelectric power generation device includes a water delivery pipeline. A power generation mechanism is mounted on and is connected to the water delivery pipeline. The power generation mechanism includes a hydraulic pump housing, an axial-flow impeller assembly and a generator. The hydraulic pump housing is mounted on and is connected to the water delivery pipeline. The axial-flow impeller assembly is rotatably mounted inside the hydraulic pump housing, and the generator is securely mounted on one side of an outside of the hydraulic pump housing and is drivingly connected with the axial-flow impeller assembly. The axial-flow impeller assembly includes a rotor, multiple vanes, that are circumferentially distributed, are mounted on an outer peripheral surface of the rotor. A power generation drive shaft is securely mounted at one end of the rotor.

Abstract: A two-dimensional monitoring system and method for a laser processing process based on a trajectory compensation mechanism are provided, including a laser light source, a probing module, a galvanometer scanner, a processing assembly, and a control module. The probing light beam from the probing module passes through the galvanometer scanner and is incident on the processing assembly, and the probing module collects returned light signals along the probing light scanning path; the processing light beam from the laser light source is incident on the processing module; the processing assembly processes the workpiece to be processed after coaxially coupling two beams of light; and the control module generates two-dimensional cross-sectional images based on light signals collected by the probing module. The present disclosure improves the controllability and stability of the processing process, and provides an intuitive and efficient online feedback means for laser processing quality control.

Abstract: The present disclosure provides a display panel and a fabrication method therefor, and a display device. The display panel includes a substrate, and isolation structures, encapsulation structures and light-emitting devices which are located on the substrate, The isolation structures include isolation openings, at least part of film layers of the light-emitting devices are located within the isolation openings, and the encapsulation structures are located on sides of the isolation structures away from the substrate and cover the light-emitting devices. Each light-emitting device and a portion of the encapsulation structure covering the light-emitting device form a microcavity structure, and the microcavity structures corresponding to the light-emitting devices emitting light of different colors are different. The solution can ameliorate the color shift problem of the display panel and increase the light extraction efficiency of the display panel.

Abstract: A microfluidic manipulation system includes a microfluidic chip having a central cylindrical chamber and a plurality of microfluidic channels arranged around the central cylindrical chamber at positions corresponding to vertices of an octahedron. Fluidic ports in fluid communication with the microfluidic channels are configured to independently introduce or withdraw fluid. An imaging system captures images of one or more particles within the central cylindrical chamber from at least two distinct focal planes. A computing device analyzes the captured images to determine particle positions relative to target positions and generates channel-specific control signals to independently regulate fluid flow through the microfluidic channels. The regulated flows generate substantially uniform flow fields for controlled, stress-reduced manipulation of microscale objects.

Abstract: Disclosed in the present invention are a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidine dione compounds and the use thereof. Specifically disclosed are a compound represented by formula (H) and a pharmaceutically acceptable salt thereof.

Abstract: Embodiments of the disclosure include methods and compositions in which NK cells are modified by the hand of man to express a heterologous a) polypeptide comprising a CD16 Fc binding domain, b) a T Cell Receptor (TCR, e.g., an invariant T Cell Receptor (iTCR)), and c) a CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively with monospecific, bispecific, and/or multi-specific antibodies, that may have modified or non-modified Fc domains.

Abstract: An IoT system, method, and medium for sensor-based human-robot collaborative monitoring are provided. The method includes: obtaining monitoring data of a work area of a collaborative robot; determining a collision risk value based on the monitoring data, a first motion trajectory of an operator, and a second motion trajectory of the collaborative robot; determine an avoidance parameter of the collaborative robot based on the monitoring data, the first motion trajectory, the collision risk value, a collision urgency degree, and a movable space range of the collaborative robot; and generating a motion control instruction based on the avoidance parameter and send the motion control instruction to a motion control system of the collaborative robot, wherein the motion control system is configured to adjust a physical drive signal applied to a joint motor based on the motion control instruction, to drive mechanical links of the collaborative robot to produce a composite motion.

Abstract: The present disclosure provides a display substrate and a display device. The display substrate includes a base substrate, a driving circuit layer, at least one planarization layer and a light-emitting device layer sequentially arranged on the base substrate. The display substrate further includes: a black pixel defining layer and a spacer on a side of the planarization layer away from the base substrate. In the first display region, an orthographic projection of the spacer on the base substrate does not overlap with orthographic projections of a pixel opening and a connection via on the base substrate. In the second display region, the orthographic projection of the spacer on the base substrate does not overlap with orthographic projections of the pixel opening and a first light-transmitting opening on the base substrate, and at least partially overlaps with the orthographic projection of the connection via on the base substrate.

Abstract: A multifunctional fitness equipment comprises a frame assembly, a drive assembly, a slide car, and a smith machine. The frame assembly includes two base frames set opposite to each other and connected by a connecting rod. A first column and a second column are connected by a gantry frame and are set in the vertical direction relative to the connecting rod. A first cross beam and a second cross beam are set horizontally on the connecting rod and the gantry frame, respectively, and a third column is set between them, thus forming a structure of the fitness equipment. A pulley assembly cooperates with a first wire rope, a second wire rope, and a third wire rope to drive movement of the slide car, achieving routing from a middle of the structure of the fitness equipment, reducing friction and increasing service life of the multifunctional fitness equipment when in use.