Abstract: A substituted heteroaryl compound, and a composition and application thereof. The compound is a compound as represented by formula (I) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as represented by formula (I). A drug composition contains the compound. The compound and the drug composition can adjust activity of a JAK kinase, particularly activity of TYK2, and are used for preventing, handling, treating and relieving diseases or disorder mediated by the activity of the JAK kinase.

Abstract: A catheter assembly may include a catheter adapter, a septum housing, and a septum. The catheter adapter may include a distal end, a proximal end, an inner wall extending between the distal end and the proximal end, and a lumen formed by the inner wall. The septum housing may include one or more protrusions and may be secured to the inner wall by one or more of the following: an interference fit between the one or more protrusions and the inner wall, a snap fit between the one or more protrusions and the inner wall, and bonding between the one or more protrusions and the inner wall. The septum may be at least partially disposed within the septum housing and configured to at least substantially seal the lumen.

Abstract: A seatbelt pretensioner system for use in a seatbelt retractor assembly having a spindle includes a frame assembly having a frame and an attachment bracket adapted to be interlocked to have an inner space for receiving the spindle, a housing adapted for being mounted to the frame and having an interior cavity, a pretensioner tube having a first tube end in fluid communication with a gas generator and a second tube end in fluid communication with the interior cavity of the housing, a pinion being rotatably mounted in the housing and fixedly coupled to the spindle adapted for taking up seatbelt webbing during pretensioning, and a pretensioner rod disposed inside the pretensioner tube. Further, the pretensioner rod has a proximal end disposed towards the gas generator and a distal end disposed away from the gas generator.

Abstract: In a stereo encoding method, a channel combination encoding solution of a current frame is first obtained, and then a quantized channel combination ratio factor of the current frame and an encoding index of the quantized channel combination ratio factor are obtained based on the obtained channel combination encoding solution, so that an obtained primary channel signal and secondary channel signal of the current frame meet a characteristic of the current frame.

Abstract: An IV access device can include a needle hub that incorporates a flash chamber. The flash chamber can be used to provide visual confirmation of proper catheter placement within a vein. The flash chamber can include a path-defining structure to facilitate identifying whether blood is continually flowing into the flash chamber. The flash chamber may also be removable from the needle hub. In some cases, the needle hub may include a paddle grip that facilitates insertion of the catheter and separation of the needle hub from the catheter adapter.

Abstract: A device rack with a braking function includes a base, a column tube, a mounting member, a plurality of universal rolling members and a brake member telescopically and movably arranged to form the device rack with a braking release state and a braking state. The base achieves centered braking on the support surface by controlling the linked brake member, which facilitates a user to adjust operating state of the device rack to switch between a rotatable and translatable braking release state and a rotatable-only braking state.

Abstract: The present application relates to a permeability evaluation method for hydrate-bearing sediment, including a complex conductivity spectrum obtaining step, a hydrate saturation calculating step based on the spectrum, a formation factor calculating step based on Archie's first law or from the complex conductivity real part, imaginary part and a conductivity of pore water; and a permeability calculating step based on relaxation time, hydrate saturation, hydrate occurrence mode correction factor and formation factor, or based on the polarization amplitude, hydrate saturation, occurrence mode correction factor and formation factor, or based on the CEC, hydrate saturation and occurrence mode correction factor, or based on the pore radius, fractal dimension, hydrate saturation and occurrence mode correction factor.

Abstract: A virtual role-based multimodal interaction method, apparatus and system, a storage medium, and a terminal, where the method includes: acquiring input information, where the input information includes one or more data types; inputting the input information into a perception layer to enable the perception layer to recognize and process the input information according to a data type of the input information to obtain a recognition result; inputting the recognition result into a logic decision-making layer to enable the logic decision-making layer to process the recognition result and generate a drive instruction corresponding to the recognition result; acquiring multimodal virtual content according to the drive instruction, wherein the multimodal virtual content includes at least a virtual role; and outputting the acquired multimodal virtual content.

Abstract: A component for a vehicle interior may comprise a composite structure comprising a cover base; a cover layer to provide a cover surface at a surface level; and an element to present a visual object. The element may present the visual object at the cover surface of the composite structure. The cover layer may comprise an aperture. The element may project from the base into the aperture of the cover layer. The element may project to a level above or below the surface level of the cover surface of the cover layer. The visual object may comprise an image, symbol, icon, logo, indicator and/or an illuminable visual object. The element may comprise a decorative layer below an underside of the cover layer. The cover layer may be molded on the cover base. The cover base may comprise a light guide to illuminate the visual object when illuminated.

Abstract: A method for discovering an unexploded ordnance in a target area includes: acquiring first feedback signals respectively corresponding to detection regions, the first feedback signals being first induced electromotive force signals; judging whether there is any abnormal signal in the first feedback signals, if there is the abnormal signal, determining the detection region corresponding to the abnormal signal is an abnormal region; acquiring second feedback signals respectively corresponding to detection sites in the abnormal region, the second feedback signals being magnetic field gradient signals; acquiring third feedback signals respectively corresponding to the detection sites, the third feedback signals being second induced electromotive force signals; acquiring location information of the detection sites; obtaining a feature spatial distribution map of the abnormal region; and judging whether there is any unexploded ordnance in the abnormal region according to the feature spatial distribution map.

Abstract: An immune enhancer comprising at least an interferon and a granulocyte-macrophage colony-stimulating factor, and an immunotherapeutic phar-maceutical composition comprising at least an antigen and the above-mentioned immune enhancers is disclosed. A preparation method of the immunotherapeutic pharmaceutical composition, the use of the immune enhancer and the immunotherapeutic pharmaceutical composition are also disclosed. The immune enhancer can be applied to disease and tumor treatments caused by viruses, bacteria, and other microorganisms.

Abstract: Provided are an ALD processing apparatus and a processing method. A reactor of the processing apparatus includes a vacuum chamber and a reaction chamber, the reaction chamber is built in the vacuum chamber and is open at a top, a bottom of the reaction chamber is formed with a gas inlet channel and a gas outlet channel arranged opposite to each other with respect to centerline of the bottom of the reaction chamber in a first direction, a lifting device is provided on the reactor, an output end of the lifting device stretches and contracts vertically and is provided with a sealing cover, which operably seals the top of the reaction chamber, a transporting device is configured to transport a substrate into the vacuum chamber, a grabbing device is provided on the sealing cover, and the grabbing device is configured to grab the substrate transported into the vacuum chamber.

Abstract: The present disclosure provides a steerable and adjustable recorder pulse pillow for Traditional Chinese Medicine pulse diagnosis, and relates to the technical field of recorder pulse pillows. The steerable and adjustable recorder pulse pillow for Traditional Chinese Medicine pulse diagnosis comprises a main body, wherein a platform is installed right above the main body. The top surface of the platform is installed with a recording device. The bottom of the recording device is provided with a rotary disc. The rear end surface of the recording device is provided with an operating button. The rotary disc is fixedly connected with a micro-motor driving wheel inside the recording device. The micro-motor is electrically connected with a rotary knob of the recording device.

Abstract: The present disclosure provides an active pharmaceutical ingredient containing a crystal form including a compound of Formula (I) and fumaric acid. An X-ray powder diffraction pattern of the crystal form obtained by using Cu-K? radiation includes at least three peaks selected from the group consisting of 10.94°±0.2° 2?, 19.06°±0.2° 2?, 23.50°±0.2° 2?, and 24.66°±0.2° 2?; a particle size D90 of the active pharmaceutical ingredient is smaller than or equal to 20 ?m, and a particle size D50 of the active pharmaceutical ingredient is smaller than or equal to 10 ?m.

Abstract: A liquid crystal optical device includes a liquid crystal layer, a first orientation layer, a second orientation layer, a first electrode layer, a second electrode layer, a first transparent substrate, and a second transparent substrate. The second electrode layer includes a conductive line and a plurality of leading-out lines. The conductive line includes a first position and a second position; one end of each leading-out line is connected with the conductive line, the other end thereof is suspended. The conductive line has at least one leading-out position; at least a part of the leading-out position is located between the first and second positions, and at least two of the leading-out positions are different from each other; a resistance between each leading-out position and the first position and a distance between at least a part of each leading-out line in a first direction and the first position satisfies a first condition.

Abstract: The present application discloses interlayers comprising half waveplate (“HWP”) films and head-up display systems incorporating the interlayers. The interlayers and head-up display systems are optimized so that the optical axis has an angle phi (?) relative to the axis formed from the p-polarization direction of a display light projected onto the plane of the HWP film. The optimized ? depends on the optical properties of the films.

Abstract: A fully-distributed reactive voltage control method, includes: establishing a power grid reactive voltage optimization model of a power grid; parting the power grid reactive voltage optimization model into a plurality of area reactive voltage optimization models of a plurality of areas of the power grid; converting a power flow equation constraint in each of the plurality of area reactive voltage optimization models to a linear regression model; solving the linear regression model by using a robust recursive regression algorithm to obtain a solution result of the linear regression model; solving each of the plurality of area reactive voltage optimization models by using the solution result of the linear regression model, a gradient projection algorithm, and an alternating direction multiplier algorithm, so as to realize a reactive voltage optimization control of each of the plurality of areas.

Abstract: An audio encoding and decoding method and related apparatus are provided. The audio encoding method may include determining a coding mode of a current frame. When determining that the coding mode of the current frame is an anticorrelated signal coding mode, the method further includes performing time-domain downmix processing on left and right channel signals in the current frame by using a time-domain downmix processing manner corresponding to the anticorrelated signal coding mode, to obtain a primary channel signal and a secondary channel signal, where the time-domain downmix processing manner corresponds to the anticorrelated signal coding mode is a time-domain downmix processing manner corresponding to an anticorrelated signal channel combination scheme, and the anticorrelated signal channel combination scheme is a channel combination scheme corresponding to a near out of phase signal.

Abstract: Valve plugs including hardened tips are disclosed herein. An example apparatus disclosed herein includes a plug holder, a sleeve coupled to the plug holder, the sleeve including a lip, a valve plug tip retained by the lip, and a spacer disposed between the plug holder and the tip, the sleeve surrounding the spacer.