Abstract: The present invention relates to RNAi constructs for reducing expression of the LPA gene, which encodes apolipoprotein(a), a component of lipoprotein(a)(Lp(a)) particles. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease, peripheral artery disease, stroke, and myocardial infarction, and to reduce serum Lp(a) levels are also described.

Abstract: An optical system for reducing the coherence of a laser beam may include an optical cavity element formed from an optically transparent material having polished surfaces. The optical cavity element may include an input port configured to inject the laser beam into the optical cavity element. The optical cavity element may include an output port configured to extract incoherent light from the optical cavity element. The laser beam may circulate within the optical cavity element based on multiple total internal reflections from at least some of the polished surfaces. Different portions of the laser beam may travel different optical path lengths within the optical cavity element. At least one of a temporal coherence or a spatial coherence may be smaller for the incoherent light than for the laser beam.

Abstract: The present application discloses a data processing method and a memory. The memory includes a plurality of memory rows, and each memory row includes a row of memory cells connected to a word line. The data processing method stores identical data into at least two memory rows, applies a turn-on voltage to at least one word line, and applies a read voltage to a plurality of word lines, so that the same bit line can synchronously read data from a plurality of memory cells. Even if some memory cells have defects, the bit line can still read correct data from the memory cells that have no defects, thereby reducing read errors of data and also improving the robustness of the memory cells.

Abstract: An optical lens includes: a first lens group, a focal power adjustable element, and a second lens group in sequence from an object side to an image side in an optical axis direction. The focal power adjustable element is configured to change a focal length of the optical lens. The first lens group includes at least two lenses. The second lens group includes at least one lens. The optical lens is specifically an auto focus lens. A focal power of the focal power adjustable element is adjusted, so that the focal length of the optical lens can be changed. This enables the optical lens to form an image of an object at different object distances and implement auto focus. In solutions provided in this application, the focal power adjustable element with a large size is placed between the first lens group and the second lens group.

Abstract: A method, an apparatus, and a medium for flywheel energy storage-assisted AGC frequency regulation of a thermal power plant are provided, relating to technical field of AGC frequency regulation. The method includes: preprocessing raw AGC instruction data to obtain target AGC instruction data; segmenting the target AGC instruction data to obtain multiple AGC instruction phases; constructing a strategy for flywheel energy storage-assisted AGC frequency regulation of a thermal power plant; utilizing a thermal power plant model to respond to a new AGC instruction under an AGC instruction advance issuance scenario, and determining a proportional relationship between output power of the thermal power plant in response to the new AGC instruction and the new AGC instruction; constructing a cost-benefit model for AGC frequency regulation system; and solving the cost-benefit model for AGC frequency regulation system to obtain an optimal ratio corresponding to each AGC instruction phase.

Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.

Abstract: A spraying system and a construction method for improving bond force between vegetation substrate and slope surface, comprising a spray gun body, a movable bracket, a nozzle velocity calculation module, and a compressor module; the spray gun body is installed at a top of the movable bracket, and the spray gun body is connected to the compressor module; the spray gun body is installed with the nozzle velocity calculation module; the nozzle velocity calculation module is connected to the compressor module and controls a spraying velocity. When the spray gun continuously changes its horizontal deflection angle, pitch angle, and the slant distance between the spray gun and the slope surface while spraying the repair substrate, the nozzle velocity calculation module can automatically retrieve relevant parameters for computation to match the nozzle velocity; subsequently, the compressor module adjusts the compression strength based on parameters such as substrate viscosity and density.

Abstract: This invention provides a pharmaceutical composition comprising an agent that can bind Siglec receptors on cell surface. This invention also provides the method of preparing said pharmaceutical composition and the use thereof.

Abstract: The invention relates to a method for predicting benchmark value of unit equipment based on XGBoost algorithm and a system thereof, wherein the method comprises the following steps: the historical operation data of unit equipment is obtained, the data is preprocessed, and a data set containing a plurality of samples is constructed, and each sample includes the benchmark value of a plurality of parameters of the equipment corresponding to a plurality of features; RF out-of-bag estimation is used for feature importance calculation to eliminate the features with low importance; the data is standardized to eliminate the dimensional effects among features; the data set is input to construct an XGBoost model, and Bayesian super parameter optimization is conducted to obtain the prediction model of benchmark values; and the real-time data of equipment operation is input, and the benchmark values of various equipment parameters are predicted by the prediction model of benchmark values.

Abstract: A direct current conversion device and system, relating to the technical field of high voltage direct current transmission. The direct current conversion device comprises a normally-on solid-state circuit breaker, a control panel and a plurality of power modules; a direct current is input into the direct current conversion device by means of the normally-on solid-state circuit breaker; the input ends of the power modules are connected in series, and the output ends of the power modules are connected in parallel; each power module is used for carrying out power conversion on the input direct current and supplying power to the control panel; and the control panel is used for receiving voltage signals and/or current signals fed back by the power modules and controlling the power modules, controlling the normally-on solid-state circuit breaker and performing signal interaction with control panels in other direct current conversion devices to enable the direct current conversion devices to be uniform in current.

Abstract: The present invention relates to RNAi constructs for reducing expression of the LPA gene, which encodes apolipoprotein(a), a component of lipoprotein(a) (Lp(a)) particles. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease, peripheral artery disease, stroke, and myocardial infarction, and to reduce serum Lp(a) levels are also described.

Abstract: Embodiments of the present disclosure relate to the technical field of network communications, and provide a digital domain self-interference cancellation method, a device, and a storage medium. The method comprises: generating a scrambling signal on the basis of a first information source inputted by a baseband unit by a fronthaul interface, and sending the scrambling signal to at least one remote radio unit; receiving a second information source sent by the remote radio unit on the basis of the scrambling signal, and performing a correction operation on a preset reference cancellation signal on the basis of the second information source to obtain a target cancellation signal; and performing self-interference cancellation processing on the second information source on the basis of the target cancellation signal to obtain a target information source.

Abstract: A multi-functional staggered massager is provided, comprising a main unit, front and rear massage assemblies detachably mounted on the main unit. The front and rear massage assemblies are driven by the main unit to move synchronously; the front massage assembly is ring-shaped and comprises a support frame and an annular soft massage ring arranged in the support frame; the rear massage assembly is composed of left and right parts that can be disassembled respectively; the left and right parts are configured to relatively fit with each other; during movement, when the rear massage assembly moves, the left and right parts perform synchronously staggered reciprocating rectilinear motions driven by the main unit. Moreover, massage rubber parts at upper and lower sections of the massager can be replaced. Users can select different types of massage rubber parts to meet personalized massage requirements.

Abstract: Embodiments of the present disclosure provide a language escape method, an apparatus, and a device and a storage medium. The method includes: splitting a target statement acquired to obtain at least one target substatement; determining a keyword type and a keyword clause contained in the target substatement; correcting the keyword clause in the target substatement according to a semantic constraint rule corresponding to the keyword type contained in the target substatement; and combining the corrected target substatement, and generating an executable machine language. The above method can effectively improve the accuracy of natural language escape and the work efficiency of a user using database query, and at the same time, reduce the technical ability requirements for the staff using database query.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: This application provides an IO request processing method, used in an external device. The external device includes a processor and a first hardware interface, and the first hardware interface is an interface that supports a PCIe protocol. The external device communicates with a physical host through the first hardware interface. One example method includes: The processor synchronizes, through the first hardware interface, queue information in storage space of a virtual machine running on the physical host to storage space of the external device, where the queue information includes one or more input/output IO requests; and the processor sends the one or more IO requests to a storage server or a network server for processing.

Abstract: A display panel and a driving baseplate, relate to the technical field of displaying. The display panel includes an active area and a peripheral area located on at least one side of the active area, and the display panel includes: a driving baseplate, including a substrate and a conducting ring embedded on a surface of one side of the substrate, wherein the conducting ring is located in the peripheral area; a light emitting device, located in the active area and disposed on a side of the driving baseplate close to the conducting ring; an isolation dam, located in the peripheral area and disposed on a side of the conducting ring away from the substrate, wherein the isolation dam overlaps with the conducting ring; and an encapsulation layer, disposed on sides of the light emitting device and the isolation dam away from the substrate.

Abstract: A method may include obtaining input symbols and a hash table. The method may also include storing the input symbols in a first buffer at a current coding position, and processed input symbols in a second buffer. The method may further include defining a plurality of delayed match window (DMW) offsets, comprising a highest DMW offset and at least one lower DMW offset. The method may also include performing a substring match search using the input symbols, the processed input symbols, and the highest DMW offset, to determine one or more candidate matches. The method may further include outputting a result from the substring match search corresponding to a determination associated with the one or more candidate matches.

Abstract: Provided are a lane line recognition method, an electronic device and a storage medium, relating to a technical field of artificial intelligence, in particular to technical fields of intelligent transportation, automatic driving and deep learning. The lane line recognition method includes: extracting a basic feature of an original image; recognizing at least one lane line node in the original image by using the basic feature of the original image; extracting a local feature from the basic feature of the original image by using the at least one lane line node; fusing the basic feature and the local feature; and recognizing a lane line in the original image based on a fused result.