Abstract: This application provides an IO request processing method, used in an external device. The external device includes a processor and a first hardware interface, and the first hardware interface is an interface that supports a PCIe protocol. The external device communicates with a physical host through the first hardware interface. The method includes: The processor synchronizes, through the first hardware interface, queue information in storage space of a virtual machine running on the physical host to storage space of the external device, where the queue information includes one or more input/output IO requests; and the processor sends the one or more IO requests to a storage server or a network server for processing. According to this application, all hardware resources of the physical host can be used to provide virtual machine services for users, thereby improving utilization of hardware resources of the physical host.

Abstract: A very fast and efficient CRISPR/Cas9 system is provided. Compositions include light-sensitive caged nucleotides at the PAM distal region of guide RNAs (gRNAcaged) to create artificial mismatches as a “roadblock”. Upon light stimulation, the caging group (“roadblock”) is removed and the gRNA fully hybridizes with the target DNA. Thus, the pre-bound inactive Cas9/gRNAcaged is rapidly converted to active Cas9.

Abstract: This invention provides a pharmaceutical composition comprising an agent that can bind Siglec receptors on cell surface. This invention also provides the method of preparing said pharmaceutical composition and the use thereof.

Abstract: This invention provides methods for producing a polymer particle which contains unusually high negative charges on the surface of the particle. Preferably, the polymer is pharmaceutically acceptable. The negative charges can be conferred by chemical groups such as carboxyl, sulfonate, nitrate, fluorate, chloride, iodide, persulfate, and many others, with carboxyl group being preferred. The invention also provides polymer particle produced by the methods of the invention.

Abstract: Methods for constructing an ADR prediction model for elderly patients, a prediction system, and/or a storage medium are disclosed. The method includes constructing ADR trigger entries for elderly patients; based on the ADR trigger entries for elderly patients, combining evidence-based evaluation results to construct a dataset of risk factors related to ADRs in elderly patients; completing the annotation of risk factors and ADR discrimination for the dataset related to ADRs in elderly patients; using the annotated dataset information to train a machine learning model, so as to obtain an ADR risk prediction model for elderly patients. A prediction system utilizing the ADR prediction model for elderly patients is constructed.

Abstract: A multi-functional staggered massager is provided, comprising a main unit, front and rear massage assemblies detachably mounted on the main unit. The front and rear massage assemblies are driven by the main unit to move synchronously; the front massage assembly is ring-shaped and comprises a support frame and an annular soft massage ring arranged in the support frame; the rear massage assembly is composed of left and right parts that can be disassembled respectively; the left and right parts are configured to relatively fit with each other; during movement, when the rear massage assembly moves, the left and right parts perform synchronously staggered reciprocating rectilinear motions driven by the main unit. Moreover, massage rubber parts at upper and lower sections of the massager can be replaced. Users can select different types of massage rubber parts to meet personalized massage requirements.

Abstract: The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)—containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.

Abstract: A loading/unloading system for a quay type full-automatic container terminal includes a plurality of shore cranes, an operation lane area between two rails of the shore cranes, an operation area from a rear side of a landside rail of the shore cranes to a yard, an automatic container yard area, an operation lane area of the yard, and facilities behind the yard. The shore cranes are disposed in parallel at a front edge of a container terminal to autonomously complete shipping and unshipping operations of containers, and autonomously complete loading/unloading processes of artificial intelligence transportation robots through information interaction with an artificial intelligence transportation robot system. The operation lane area between two rails of the shore cranes includes: a lambdoidal reverse operation area of inner container trucks, a ship lofting operation area, and a loading/unloading operation area of the inner container trucks, which are physically isolated by fences.

Abstract: Provided are a display panel and a manufacturing method thereof, a display device and a spliced display device. The display panel includes: a color filter substrate (11), an array substrate (12) and a first conductive portion (13), where a display region (AA) and a peripheral region (NA) are formed on the display panel, and the peripheral region (NA) surrounds the display region (AA); the array substrate (12) includes pixel circuits and a second conductive portion (14), where the pixel circuits are located in the display region (AA), and the second conductive portion (14) is located in the peripheral region (NA); the second conductive portion (14) is connected with the pixel circuits; the first conductive portion (13) is located on a side surface of the array substrate (12) and a side surface of the color filter substrate (11), and the first conductive portion (13) is connected with the second conductive portion (14).

Abstract: A nano check valve osmosis and energy collection method and device are provided, which includes principles and methods of osmosis and energy collection technology proposed based on principles of nano check valves and osmotic effects. By providing two semipermeable membranes and filling a solution, cooperating with a concentration control module, solution concentrations at interfaces of the semipermeable membranes are regulated. This ensures that concentrations near the two semipermeable membranes are different, allowing for regulation of osmotic pressure and creation of a check valve effect. It automatically rectifies disordered, high-speed thermal motion of solvent molecules into an orderly unidirectional flow, forming potential energy of the liquid level or kinetic energy of liquid flow for energy storage or power generation. The device can extract molecular thermal kinetic energy from the environment to generate electricity, without consuming energy resources or increasing the Earth's temperature rise.

Abstract: A reciprocating mechanism for driving a synchronous belt through forward and reverse rotation of a motor comprises: a mounting bracket, a motor, a grating, a slot-type opposing photoelectric switch, a control board, a Hall switch, a load, and a magnet. The mounting bracket is equipped with a driving wheel and a driven wheel, which driving wheel is connected to the driven wheel through the synchronous belt. A side of the mounting bracket is provided with the motor. An output shaft of the motor is connected to the driving wheel and extends to the other side of the mounting bracket. The other side of the mounting bracket is provided with the control board which is functionally connected to the motor. A lower end of the control board is provided with the slot-type opposing photoelectric switch which mates with the grating mounted on a free end of the output shaft of the motor.

Abstract: An interaction method includes displaying a video interaction interface in a live streaming application, the video interaction interface including a social video uploaded by a live streaming account; receiving a selection operation on the social video; and based on a social relationship confirmation signal of the live streaming account, displaying an interaction interface for a social interaction with the live streaming account.

Abstract: Disclosed are a RISC-V and O-CFI mechanism-based defense method and apparatus for code reuse attacks, comprising: constructing a control flow graph according to program source codes randomized in a basic block order; on the basis of the control flow graph, obtaining a boundary range of a control flow transfer branch; executing the program source codes, obtaining a target node to which each control flow is to be transferred, and analyzing each target node in combination with the boundary range so as to defend against an abnormal control flow. The present invention can identify an illegal control flow transfer with the assistance of RISC-V security hardware according to the characteristics of a program control flow itself, and effectively handle code reuse attacks, thereby enhancing the security defense capabilities of an RISC-V system.

Abstract: The disclosure provides a control method, a control apparatus and a cloud-based control system, and belongs to the technical field of cloud-based control.

Abstract: Disclosed herein are polypeptides having activity as agonists of a glucagon receptor (“GCGR”), molecules comprising such polypeptides and a half-life extending domain (e.g., an Fc-containing polypeptide), including molecules comprising an antibody that specifically binds to a glucose-dependent insulinotropic polypeptide receptor (“GIPR”), pharmaceutical compositions comprising such polypeptides and molecules, and methods of using such polypeptides, molecules, and pharmaceutical compositions in weight management and the treatment of certain disorders such as obesity.

Abstract: A housing structure of an electric drive assembly and an electric drive assembly are provided. The housing structure comprises a motor housing, a reducer housing, a controller housing, an oil cooling assembly, and a water cooling assembly. At least two housings of the motor housing, the reducer housing, and the controller housing are in an integrated structure. The oil cooling assembly comprises an oil pumping unit and an oil passage, the oil passage is provided inside the motor housing and inside the reducer housing, the oil pumping unit is communicated with the oil passage and conveys lubricating oil in the reducer housing to the oil passage. The water cooling assembly comprises a water passage which is a circulating water channel provided inside the controller housing and inside the motor housing, and the water passage is connected to a cooling water source of a vehicle.