Abstract: This invention provides polymeric nanoparticles presenting non-conjugated BBB-crossing ligands on their surfaces, compositions and methods of use thereof, as well as non-conjugation methods to produce nanoparticles having BBB-crossing agents on their surfaces.

Abstract: This invention provides polymer particles which contain negative charges on the surface of the particle. Preferably, the particles comprise PLGA and sulfate polymer. The invention also provides polymer particle produced by the methods of the invention.

Abstract: The disclosure provides nanoparticles of indirubin and methods of making and using these particles for the treatment of cancer, neurodegenerative disorders and inflammatory diseases. The effective average particle size of the nanoparticles is less than 2000 nm.

Abstract: In general, in one aspect, the disclosure describes a Universal Plug and Play (UPnP) Remote Access Server (RAS) to provide a communication channel between UPnP Remote Access Clients (RACs) connected thereto. The UPnP RAS maintains local discovery information for UPnP devices connected to a local network and remote discovery information for remote UPnP devices communicating therewith. The UPnP RAS provides the remote UPnP devices communicating therewith with the local discovery information and the remote discovery information. The remote discovery information is utilized by a first remote UPnP device to discover a second UPnP device and vice versa. After discovery, a first remote UPnP device can communicate with a second UPnP device and vice versa.

Abstract: This invention provides a pharmaceutical composition comprising an agent that can bind Siglec receptors on cell surface. This invention also provides the method of preparing said pharmaceutical composition and the use thereof.

Abstract: This application provides an IO request processing method, used in an external device. The external device includes a processor and a first hardware interface, and the first hardware interface is an interface that supports a PCIe protocol. The external device communicates with a physical host through the first hardware interface. The method includes: The processor synchronizes, through the first hardware interface, queue information in storage space of a virtual machine running on the physical host to storage space of the external device, where the queue information includes one or more input/output IO requests; and the processor sends the one or more IO requests to a storage server or a network server for processing. According to this application, all hardware resources of the physical host can be used to provide virtual machine services for users, thereby improving utilization of hardware resources of the physical host.

Abstract: A USB switching circuit includes a first multiplexer, a second multiplexer coupled with the first multiplexer through transmission paths, and a voltage regulation circuit coupled with the first and second multiplexers. The first multiplexer distributes first data signals to the transmission paths according to first control signals. The second multiplexer distributes a second data signal to the transmission paths according to second control signals. The voltage regulation circuit sets a maximum voltage and a minimum voltage of the first data signals to corresponding to a common voltage. The maximum voltage of the first data signals is not higher than a maximum voltage of the second control signals, or the minimum voltage of the first data signals is not lower than a minimum voltage of the second control signals. The first data signals and the second data signal are generated according to different communication protocols.

Abstract: An unmanned aerial vehicle control method and apparatus are provided. The method includes: obtaining, in real time, the motion status information of an unmanned aerial vehicle moving under the effect of a user-applied external force (100); generating at least one unmanned aerial vehicle control instruction based on the motion status information (110) and controlling the unmanned aerial vehicle to perform a corresponding flight action according to the at least one unmanned aerial vehicle control instruction (120). After an unmanned aerial vehicle moves under the effect of a user-applied external force, the control method further controls the unmanned aerial vehicle to perform a corresponding flight action according to the current motion tendency of the unmanned aerial vehicle, thus freeing the user from mastering a complicated unmanned aerial vehicle control technology, reducing the difficulty of the control over the unmanned aerial vehicle and making the unmanned aerial vehicle more applicable.

Abstract: A pre-booster pumping system for increasing power generation of a turbine of a thermal power plant includes a booster pump system including an inlet end, an output end and at least one booster pump; the inlet end of the booster pump system being connected to the air draining end of the turbine through an input tube; each booster pump including an air inlet and an air outlet; the waste gas drained from the air draining end of the turbine being inputted to the booster pump; the vapor pressure being increased in the booster pump and then the vapor being outputted from the output end; and a condenser having an input end; the output end of the booster pump system being connected to the condenser through the output tube; the condenser serving to receive the waste gas from the booster pump system and cool the waste vapor as water.

Abstract: The invention discloses a non-linear Lamb wave mixing method for measuring stress distribution in thin metal plates. The method is suitable for stress distribution detection and stress concentration area positioning in a plate structure and belongs to the field of nondestructive detection.

Abstract: The present invention relates to chemically-modified RNAi constructs for reducing expression of a target gene. In particular, the invention relates to specific patterns of modified nucleotides to be incorporated into RNAi constructs to improve in vivo stability and efficacy. Also described are pharmaceutical compositions comprising the chemically-modified RNAi constructs and methods of inhibiting target gene expression in vivo by administering the chemically-modified RNAi constructs, for example, to treat or ameliorate various disease conditions.

Abstract: A base substrate includes a first base layer and an electrostatic resistant layer that are disposed in a stack.

Abstract: The disclosed embodiments provide a system for processing data. During operation, the system obtains a set of records from a set of inputs, with each record containing an entity key, a partition key, and one or more attribute-value pairs. Next, the system sorts and indexes the records by the entity key for each partitioned input. The system then processes a query of the records by matching entity key values to the sorted and indexed records for each input partition in the query. Next, the system merges the subset of records with the same entity key values into records, with each merged record containing an entity key field and a single field that includes a list of attribute-value pairs from the subset. Finally, the system outputs the merged records in response to the query.

Abstract: Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation or IDH2 mutation.

Abstract: The present invention discloses a method and a system of obtaining and tracking the posture of a subject. Electromagnetic field transceivers may be placed at various locations on the subject, and may be coupled to a processor device, which may be disposed on the back of the subject. The processor device may send waveforms to selected electromagnetic field transceivers located at positions to be tracked. The selected electromagnetic field transceivers may transmit signals corresponding to these waveforms to additional electromagnetic field transceivers located near an origin point. Signals received by these additional electromagnetic field transceivers may be sent to the processor device, which may, based on voltage amplitudes/magnitudes of the received signals, determine the positions and motion trajectories for the electromagnetic field transceivers, which may correspond to positions and motion trajectories of different parts of the subject's body.

Abstract: A quick-connect modular LED lamp strip includes an H-shaped lamp body, a PC lampshade in a movably snap-fit connection with an upper portion of the lamp body, a plug wiring assembly connected with the lamp body, a printed circuit board (PCB) circuit board disposed inside the lamp body, and end caps disposed on each of head position of two ends of the lamp body and configured to block the two ends of the lamp body. The end caps are in an L-shaped structure, and each of the end caps includes an end cap insert configured to insert into the lamp body and at least one fixing column integrally formed with the end cap insert and configured to connect with the plug wiring assembly.

Abstract: A power saving vacuuming pump system is based on complete-bearing-sealing and dry-large-pressure-difference root vacuuming root pumps includes an input valve at an input end of a vacuum space for receiving gas mixture of saturation water vapor and non-condensed air from a condenser of a power plant; a first root vacuum pump connected to the input valve for receiving gas mixture from the input valve and then compressing the gas mixture; a second root vacuum pump connected to the first root vacuum pump for receiving gas mixture from the first root vacuum pump and then compressing the gas mixture. Inner connection walls between the vacuum chamber and the two bearing rooms are installed respective bearings which are installed to be around the driving shaft, and thus all the vacuum chamber and the two bearing rooms are tightly sealed. The vacuum chamber is completely dried so as to prevent from internal emulsion.

Abstract: A message transmission method and apparatus in a cluster file system includes determining, by a first host in a cluster file system, that the message network link is faulty; switching from the message network link for message transmission to a storage channel; generating a first message; and recording the first message in a first location area of a data storage medium, where the first location area is used by a second host to access and read the first message.

Abstract: Disclosed are a sensor assembly, an inertial measurement assembly and a mobile device. The sensor assembly comprises a first fixing member, a second fixing member and a first circuit board provided with at least one sensor module. The second fixing member is connected to the first fixing member, and the second fixing member is opposite to and spaced apart from the first fixing member to define a mounting space, the first circuit board is arranged in the mounting space, the first circuit board is fixedly connected to at least one of the first fixing member and the second fixing member, and at least part of the first circuit board is not parallel and not perpendicular to the horizontal plane.