Abstract: The present disclosure provides compositions and methods comprising spherical nucleic acid (SNA) components for use as immunotherapeutic agents. The disclosure provides a method comprising: treating a population of antigen presenting cells with a SNA comprising a nanoparticle, an antigen, and an adjuvant; and determining a time at which the population of antigen presenting cells presents a maximal signal that is indicative of antigen presentation by the antigen presenting cells and a time at which the population of antigen presenting cells presents a maximal co-stimulatory signal due to the adjuvant. The disclosure includes compositions that comprise a pharmaceutically acceptable carrier and a SNA of the disclosure, wherein the SNA comprises a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen that is associated with the surface of the SNA via a linker. The disclosure additionally includes articles of manufacture and kits.

Abstract: A mechanical energy-based self-powering counting system is provided. The system includes an electromagnetic power generator, a count measuring circuit, a count energy supply circuit, a controller and a wireless transmission module. The electromagnetic power generator is driven by an external device and produces an electric signal and outputs the electric signal to the controller after passing it through the count measuring circuit. The controller processes the received signal, updates a count according to certain programming rules and sends data to the wireless transmission module. The energy from the electromagnetic power generator flowing through the count measuring circuit can supply power to the controller. An energy storage module in the count energy supply circuit performs voltage feedback on the controller. The controller monitors the voltage of the energy storage module to control whether it enters a charging state.

Abstract: Fault diagnosis and prognosis (FDP) is critical for ensuring system reliability and reducing operation and maintenance (O&M) costs. Lebesgue sampling based FDP (LS-FDP) is an event-based approach with the advantages of cost-efficiency, uncertainty management, and less computation. In previous works, LS-FDP approaches are mainly model-based. However, fault dynamic modeling is difficult and time consuming for some complex systems and this severely hinders the applications of LS-FDP. To address this problem, this present disclosure presents a data-driven based LS-FDP framework in which deep belief networks (DBN) and particle filter (PF) are integrated to achieve fault state estimation and remaining useful life (RUL) prediction. In the proposed approach, DBN learns the state evolution model and the Lebesgue time transition model, which are used as diagnostic and prognostic models in PF for FDP.

Abstract: A display apparatus and a preparation method thereof, the display apparatus includes a display panel whose display area has a first hole; a polarizer disposed on one side of the display panel, wherein the polarizer has a blind hole, the blind hole penetrates through an optical characteristic layer in the polarizer, and an orthographic projection of the blind hole on the display panel at least partially overlaps with the first hole; a first optical adhesive layer disposed on a surface of the polarizer away from the display panel, wherein the first optical adhesive layer includes a planar portion and a convex portion, and the convex portion is filled in the blind hole; a cover plate disposed on one side of the first optical adhesive layer away from the display panel.

Abstract: Deep learning-based diagnosis methods currently face some challenges and open problems. First, domain knowledge of fault modes and operating conditions are not integrated in most existing approaches, which results in low diagnosis accuracy and training efficiency. Second, existing methods treat all features with indiscriminate attention, which causes unnecessary computation and even false diagnosis results in some cases. Third, multi-task diagnosis becomes more important for health maintenance. To address these challenges, a deep residual convolutional neural network is provided with an enhanced discriminate feature learning capability and information fusion for multi-task bearing fault diagnosis. Domain knowledge is integrated with monitoring data to build the information map. Two attention modules are introduced to enhance the discriminate feature learning ability, and two classifiers are employed for multi-task diagnosis, providing significant improvements in diagnostic accuracy and training efficiency.

Abstract: Disclosed are a touch panel and an electronic device, the touch panel is provided with a touch area and a non-touch area surrounding the touch area, a plurality of first touch electrodes and a plurality of second touch electrodes are all located in the touch area, a plurality of connecting portions include a first connecting portion, a second connecting portion, and a third connecting portion sequentially away from the non-touch area in a first direction, and a distance between a center of an orthographic projection of the first connecting portion on a substrate and a center of an orthographic projection of the second connecting portion on the substrate is less than a distance between the center of the orthographic projection of the second connecting portion on the substrate and a center of an orthographic projection of the third connecting portion on the substrate.

Abstract: Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds. The methods include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence to treat red blood cell disorders. Other methods provided herein include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence and a tyrosine kinase inhibitor to treat cancer.

Abstract: The present invention provides a method and system for acquiring operating parameters of a photographic lens, including: a control circuit and a storage unit that are configured in the photographic lens, where the control circuit acquires an operating parameter of the photographic lens by using a focusing ring position sensor, a zoom ring position sensor, an aperture ring position sensor, an accelerometer and a gyro sensor; and the control circuit is further connected to a camera or an external data reading device by using a communication interface, to output the operating parameter after data encapsulation in real time.

Abstract: The present disclosure relates to an electronic display device, including a rigid substrate including a first surface, a second surface opposite the first surface, and a side surface coupled between the first surface and the second surface, a flexible OLED layer including a first body segment extending over the first surface of the rigid substrate to form a display front surface of the electronic display device, a second body segment extending over the second surface of the rigid substrate to form a back surface of the electronic display device, and a bent segment coupled between the first body segment and the second body segment, and a functional component coupled to the second body segment of the flexible OLED layer to implement a display function of the electronic display device, the functional component being hidden on the back surface of the electronic display device.

Abstract: A material transferring method includes: controlling a first robot transferring materials to move to a first entrance of the M entrances; and controlling the first robot to place a first quantity of materials at the first entrance, the first quantity being less than or equal to a second quantity. The first entrance is one of the M entrances that is in an idle state. The second quantity is a total quantity of materials to be placed on the conveyor line by the first robot.

Abstract: Provided are low-residual-alkali high-nickel ternary positive-electrode material, preparation method and application thereof. The preparation method of a low-residual-alkali high-nickel ternary positive-electrode material includes: presintering a nickel-containing precursor and a lithium salt to obtain a presintered material, and performing primary high-temperature sintering on the presintered material and a dopant, wherein the presintering is controlled to be performed under a micro-negative pressure condition, such that water of the lithium salt and carbon dioxide generated by a primary reaction of the precursor and the lithium salt can be fully discharged.

Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.

Abstract: The present application relates to a display device. The display device includes a flexible display panel including display and back surfaces in a thickness direction thereof; a supporting back film located on the back surface, and including a bendable area and fixed areas located at opposite sides of the bendable area in a first direction; and an adhesive part located between the fixed area and the back surface, and adhered to the fixed area and the back surface; and a flexible supporting part located between the bendable area and the back surface, and being in contact with the bendable area and the back surface. The flexible supporting part is in direct contact with the back surface of the flexible display panel.

Abstract: A non-transitory computer-readable medium stores instructions readable and executable by a workstation (18) including at least one electronic processor (20) to perform an image reconstruction method (100). The method includes: determining a weighting parameter (13) of an edge-preserving regularization or penalty of a regularized image reconstruction of an image acquisition device (12) for an imaging data set obtained by the image acquisition device; determining an edge sensitivity parameter (?) of the edge-preserving algorithm for the imaging data set obtained by the image acquisition device; and reconstructing the imaging data set obtained by the image acquisition device to generate a reconstructed image by applying the regularized image reconstruction including the edge-preserving regularization or penalty with the determined weighting and edge sensitivity parameters to the imaging data set obtained by the image acquisition device.

Abstract: Examples of the present disclosure include methods and/or systems for fault diagnosis and solution recommendation. A method may include: obtaining original data including fault problem of a target device; analyzing the original data including fault problem to obtain problem description information; analyzing the problem description information to obtain a diagnosis report; and, according to the diagnosis report, obtaining a video and/or document solution for the fault based on a cloud knowledge map, and recommending the solution to a user. The knowledge map comprises: nodes representing the fault, video solution and/or document solution, and multiple edges representing the relationship between nodes.

Abstract: The disclosure relates to a method for playing an animation. The method includes: obtaining a target animation based on a setting operation for switching between a camera application and an image storage program. The target animation is an animation of a target image displayed when switching between the camera application and the image storage program. The target animation is played in a transparent window. The transparent window covers an application interface of the camera application as an upper layer of the application interface.

Abstract: A touch panel includes first touch electrodes and second touch electrodes. At least one first touch electrode includes first sub-electrodes electrically connected to one another and first connecting sub-portions located between and electrically connecting every two adjacent first sub-electrodes. At least one second touch electrode includes second sub-electrodes electrically connected to one another and second connecting sub-portions located between and electrically connecting every two adjacent second sub-electrodes. At least one first connecting sub-portion at least partially overlaps at least one second connecting sub-portion so as to form a stacked structure as a connecting portion. The touch panel includes an opening area, and the connecting portions include at least one adjacent connecting portion adjacent to the opening area, where a center of an orthographic projection of the adjacent connecting portion does not overlap a first intersection point and is located outside the opening area.

Abstract: Examples of the present disclosure provide a parameter optimization method, device and computer readable storage medium. The method includes: establishing a one-to-one functional relationship between each parameter and each performance index; determining each current correlation coefficient between the parameter and each performance index based on the one-to-one function relationships; obtaining a current weight of each performance index; according to current weights and current correlation coefficients, obtaining a current influence coefficient of each parameter on a comprehensive performance of the performance indexes; and determining important optimization parameters according to the current influence coefficient; for each two parameters, calculating a current correlation coefficient of the two parameters, and determining an adjustment parameter; and performing parameter optimization based on the important optimization parameters and the adjustment parameters.

Abstract: This application discloses a watchband clasp, a watchband, and a wearable device. The watchband clasp (1000) includes a first fastener (1), a second fastener (2) rotatably mounted on the first fastener (1), a cover plate (3) rotatably mounted at an end that is of the second fastener (2) and that is away from the first fastener (1), a hook member (4) slidably mounted on the cover plate (3), and an elastic member (5) mounted between the cover plate (3) and the hook member (4). The elastic member (5) can enable the hook member (4) to maintain a clamped state with an inner wall of a hook hole (11). The cover plate (3) is provided with a first accommodation slot (35) used to accommodate the first fastener (1) and the second fastener (2).

Abstract: A device and method for sputtering and depositing metal on the surface of magnetic powder materials utilizes a vacuum chamber, a vacuum pump set, a magnetron sputtering target, a cathode ion source, a water-cooled anode, and a sample holding component arranged in the vacuum chamber. The sample holding component is a sample roller, an axis of the sample roller is arranged in a horizontal direction, the sample roller can rotate around the axis thereof. Two ends of the sample roller are open, and the sample roller further comprises a power device capable of driving the sample roller to rotate. The cathode ion source and the magnetron sputtering target extend inwards into the sample roller from the opening in the same end of the sample roller. The water-cooled anode extends inwards into the sample roller from the opening in the other end of the sample roller.