Patents by Inventor Binata Joddar

Binata Joddar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230374299
    Abstract: Cardiac tissue-on-a-chip platforms aimed at mimicking human cardiac tissue structures, are valuable tools to model, and serve as preclinical platforms for drug testing or therapies for cardiac repair. We have developed three types of electrospun scaffolds including furfuryl gelatin (f-gelatin) alone, with polycaprolactone (PCL) in the ratio of f-gelatin and PCL (1:1), and coaxial scaffolds with PCL (core) and f-gelatin (sheath). Scaffolds were developed through single nozzle electrospinning and coaxial electrospinning, respectively, to serve as scaffolds for cardiac tissue-on-a-chip platforms.
    Type: Application
    Filed: April 18, 2023
    Publication date: November 23, 2023
    Inventors: Binata Joddar, David A. Roberson, Naveen Nagiah, Zayra N. Dorado, Ivana Hernandez
  • Patent number: 11370757
    Abstract: Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: June 28, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Katja Michael, Chunqlang Li, Thomas Boland, Hector P. Del Castillo, Binata Joddar, Alfredo Ornelas Sanchez, Javier Hernandez Ortega, Irodiel Vinales Lozano, Philip T. Baily
  • Publication number: 20210130294
    Abstract: Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.
    Type: Application
    Filed: October 19, 2020
    Publication date: May 6, 2021
    Inventors: Katja Michael, Chunqlang Li, Thomas Boland, Hector P. Del Castillo, Binata Joddar, Alfredo Ornelas Sanchez, Javier Hernandez Ortega, Irodiel Vinales Lozano, Phillip T. Baily
  • Publication number: 20190111132
    Abstract: A novel 34 amino acid long collagen-like peptide rich in proline, hydroxyproline, and glycine, and with several photoreactive N-acyl-7-nitroindoline units incorporated into the peptide backbone was synthesized by on-resin fragment condensation. The circular dichroism measurement of this peptide supports a stable triple helix structure. This peptide has potential as a new biomimetic material with built-in latent photochemical functions that enable the decomposition into small peptide fragments by illumination with UV light of 350 nm. Using a photoreactive glycine derivative as a model compound for the collagen-like peptide, we demonstrate that its photolysis can also be triggered by a two-photon absorption process using a femtosecond laser at 710 nm. When a thin film of this compound is irradiated with femtosecond laser light at 710 nm the photochemistry occurs only at locations of irradiation.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 18, 2019
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Chunqiang Li, Thomas Boland, Hector P. Del Castillo, Katja Michael, Binata Joddar, Alfredo Ornelas
  • Patent number: 8529951
    Abstract: Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: September 10, 2013
    Inventors: Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar