Patents by Inventor Binfeng Lu

Binfeng Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CATIONIC AMPHIPHILIC POLYMERS FOR CODELIVERY OF HYDROPHOBIC AGENTS AND NUCLEIC ACIDS
    Publication number: 20240131170
    Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
    Type: Application
    Filed: December 14, 2023
    Publication date: April 25, 2024
    Inventors: Song Li, Jingjing Sun, Yichao Chen, Yixian Huang, Yanhua Liu, Binfeng Lu
  • Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids
    Patent number: 11857634
    Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
    Type: Grant
    Filed: April 20, 2019
    Date of Patent: January 2, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Song Li, Jingjing Sun, Yichao Chen, Yixian Huang, Yanhua Liu, Binfeng Lu
  • METHODS OF TREATING CANCER
    Publication number: 20230338384
    Abstract: The present disclosure relates to the use of a KRAS inhibitor and an oncolytic virus to prevent and/or treat cancer. The methods include prevention and/or treatment of cancer with the administration of a KRAS inhibitor and an oncolytic virus to a subject. The present disclosure further provides kits for performing such methods.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 26, 2023
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Zong Sheng GUO, Binfeng LU, Zhi ZHU, Hongqi CHEN
  • IL-36 CYTOKINE EXPRESSING ONCOLYTIC VIRUSES FOR TREATING CANCER
    Publication number: 20220211814
    Abstract: The present disclosure provides interleukin-36 (IL-36) cytokine (e.g., IL-36?) expressing oncolytic viruses, and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent.
    Type: Application
    Filed: March 17, 2022
    Publication date: July 7, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Zong Sheng GUO, Binfeng LU, David L. BARTLETT
  • CATIONIC AMPHIPHILIC POLYMERS FOR CODELIVERY OF HYDROPHOBIC AGENTS AND NUCLEIC ACIDS
    Publication number: 20210236645
    Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
    Type: Application
    Filed: April 20, 2019
    Publication date: August 5, 2021
    Inventors: Song Li, Jingjing Sun, Yichao Chen, Yixian Huang, Yanhua Liu, Binfeng Lu