Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Abstract: A system and method for regenerating optical signals comprising a clock recovery circuit coupled to a transmission line, a first optical gating device having an input port coupled to the transmission line and a clock port coupled to the clock recovery circuit, and a second optical gating device having an input port coupled to a continuous wave (CW) laser and a clock port coupled to the output of the first optical gating device, wherein the optical gating devices may be terahertz optical asymmetric demultiplexers (TOADs).

Abstract: A Terahertz Optical Asymmetric Demultiplexer (TOAD) having preferably two non-linear elements (NLES) in which the extinction ratio is enhanced by saturating both NLEs when closing a switching window. A data signal input on one port of the TOAD is split onto two optical paths, each including one NLE. The optical paths converge at an output port. To start a switching window, a first control signal is input on an optical path that includes only one of the two NLEs. To close a switching window, one or more control signals are input such that both NLEs receive a control signal at a predetermined time after the first control signal is received by one of the NLEs. Only data signals passing through the first NLE during the switching window are output on the output port. Since both NLEs receive a second control signal at the same time, they decay together and thus avoid creation of unintended switching windows.

Abstract: A Terahertz Optical Asymmetric Demultiplexer (TOAD) having preferably two non-linear elements (NLES) in which the extinction ratio is enhanced by saturating both NLEs when closing a switching window. A data signal input on one port of the TOAD is split onto two optical paths, each including one NLE. The optical paths converge at an output port. To start a switching window, a first control signal is input on an optical path that includes only one of the two NLEs. To close a switching window, one or more control signals are input such that both NLEs receive a control signal at a predetermined time after the first control signal is received by one of the NLEs. Only data signals passing through the first NLE during the switching window are output on the output port. Since both NLEs receive a second control signal at the same time, they decay together and thus avoid creation of unintended switching windows.