Patents by Inventor Bing Cui

Bing Cui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230341412
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: November 22, 2022
    Publication date: October 26, 2023
    Inventors: Thomas J. KIPPS, George F. WIDHOPF, II, Bing CUI
  • Patent number: 11654193
    Abstract: There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically acceptable excipient. In embodiments, the BTK antagonist is ibrutinib and the ROR-1 antagonist is cirmtuzumab.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: May 23, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, Liguang Chen, Bing Cui
  • Publication number: 20230135646
    Abstract: A replaceable and fatigue-avoided orthotropic plate structure includes a plurality of U rib components detachably arranged. The U rib component includes a U rib. The upper end of the U rib is fixedly connected to the roof plate in a non-welded manner. A replacing method includes that when a structural abnormality is detected in a target U rib component, sequentially removing connecting pieces between a connecting plate corresponding to the target component and a diaphragm; pulling out the connecting plate and the limiting plate corresponding to the target component; sequentially removing connecting pieces between an upper end of a U rib corresponding to the target component and the roof plate; installing a U rib component for replacement at a position corresponding to the target component with the connecting pieces; and installing the connecting plate and the limiting plate at the original position with the connecting pieces.
    Type: Application
    Filed: October 29, 2021
    Publication date: May 4, 2023
    Inventors: Bing CUI, Canhui ZHAO, Huanling WU, Zhiming GUO, Liang TANG
  • Publication number: 20230110249
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Application
    Filed: March 16, 2022
    Publication date: April 13, 2023
    Inventors: Thomas James KIPPS, Jian YU, Bing CUI, Liguang CHEN, George F. WIDHOPF, Charles PRUSSAK
  • Patent number: 11536727
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: December 27, 2022
    Assignee: The Regents of the University of California
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Patent number: 11312787
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 26, 2022
    Assignee: The Regents of the University of California
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Patent number: 11105084
    Abstract: A dry connection prefabricated assembly steel-concrete composite beam, comprising a steel beam (400), a concrete slab (300) composed of steel bars (301) and concrete, a steel plate connector (100) composed of a steel plate (101), shear connection pieces (102) and connection rods (103), and a pair of inter-plate connection pieces respectively composed of an upper connection plate (501), a lower connection plate (502), a horizontal connection plate (503), a triangular reinforcing steel plate (504) and first and second shear connection pieces (505, 507).
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: August 31, 2021
    Inventors: Bing Cui, Canhui Zhao, Zhengyu Liu
  • Publication number: 20210208158
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: December 22, 2020
    Publication date: July 8, 2021
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Publication number: 20210038716
    Abstract: There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically acceptable excipient. In embodiments, the BTK antagonist is ibrutinib and the ROR-1 antagonist is cirmtuzumab.
    Type: Application
    Filed: May 8, 2020
    Publication date: February 11, 2021
    Inventors: Thomas J. Kipps, Liguang Chen, Bing Cui
  • Patent number: 10900973
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: January 26, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Publication number: 20200309785
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: January 30, 2020
    Publication date: October 1, 2020
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Patent number: 10688181
    Abstract: There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically acceptable excipient. In embodiments, the BTK antagonist is ibrutinib and the ROR-1 antagonist is cirmtuzumab.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: June 23, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, Liguang Chen, Bing Cui
  • Patent number: 10627409
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Publication number: 20190389962
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Application
    Filed: May 14, 2019
    Publication date: December 26, 2019
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Patent number: 10344096
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Publication number: 20180348232
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Application
    Filed: February 12, 2018
    Publication date: December 6, 2018
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Patent number: 9933434
    Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: April 3, 2018
    Assignee: The Regents of the University of California
    Inventors: Thomas J. Kipps, George F. Widhopf, II, Bing Cui
  • Publication number: 20180066063
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Application
    Filed: June 9, 2017
    Publication date: March 8, 2018
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak
  • Publication number: 20170368173
    Abstract: There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically acceptable excipient. In embodiments, the BTK antagonist is ibrutinib and the ROR-1 antagonist is cirmtuzumab.
    Type: Application
    Filed: June 27, 2017
    Publication date: December 28, 2017
    Inventors: Thomas J. Kipps, Liguang Chen, Bing Cui
  • Patent number: 9758591
    Abstract: The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 12, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Thomas James Kipps, Jian Yu, Bing Cui, Liguang Chen, George F. Widhopf, II, Charles Prussak