Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.

Abstract: A power factor correction converter that outputs a DC output voltage from an AC input voltage, includes two channels each including a high-side switch and a low-side switch connected in cascade between a positive output terminal and a negative output terminal of the power factor correction converter and with a node between the high-side switch and the low-side switch; an inductor connected to a first terminal of the AC input voltage and the first node; a gate driver connected to the second high-side switch and the second low-side switch; a bootstrap circuit connected to the second node and the gate driver; wherein the second node is connected to a second terminal of the AC input voltage; and the bootstrap circuit is pre-charged at beginnings of negative half-cycles of the AC input voltage.

Abstract: Provided are compounds that are suitable for cryopreservation of cells. The compounds are non-toxic, water soluble, and free of any organic solvents. The compounds have the following structure: Formula (I), where n is 1, 2, 3, or 4 and each R is independently H or Formula (II), where each R? is independently chosen from aliphatic groups, aryl groups, and amino acid groups and at least one R is not H and the asterisked carbon has R or S stereochemistry or a racemate thereof. Also provided are compositions and methods of using the compounds to cryopreserve cell populations.

Abstract: Provided are aromatic oligoamide foldamers and self-assembled compositions of the same. The aromatic oligoamide foldamers and compositions can form tube-like structures that can form pores in membranes. The pores can be used to transport ions and molecules, such as, for example, cryoprotective agents or therapeutic agents, through the membrane. The tube-like structures exhibit desirable stability at low temperatures.

Abstract: The present disclosure provides linear and cyclic oligoamides. The present disclosure also provides methods of making and uses of linear and cyclic oligoamides. The linear and/or cyclic oliogoamides may be used in methods such as, for example, forming transmembrane pores for transmembrane transport of hydrogen-bond acceptors and/or ions, sequestering hydrogen-bond acceptors and/or ions (e.g., anions), or the like. Compounds of the present disclosure may be used to enrich materials with ions (e.g., lithium).

Abstract: Provided is a terminal device, including a photosensitive element, a display panel provided with a light-transmitting region, and a circuit board disposed between the photosensitive element and the display panel and being provided with a light-transmitting hole. The light-transmitting region is a region where light is able to pass through the display panel. The light-transmitting hole is disposed between the photosensitive element and the light-transmitting region of the display panel in a direction perpendicular to a light-exiting surface of the display panel.

Abstract: A sample feed device is provided, including: a body; a sample tray provided on the body; a moving part provided on the body and capable of reciprocating on the body, and the moving part provided with a transfer chamber, the transfer chamber capable of receiving a sample from the sample tray and transferring the sample to an analyzer with the movement of the moving part; a processing system provided on the body, and capable of performing helium gas purging and vacuum processing to the sample. The sample feed device may feed the sample automatically through relay transfer of the sample by the sample tray and the moving part. The processing system may perform the helium gas purging and vacuuming to the sample, which strips adsorbate on the surface of the sample by the helium gas purging, and removes the stripped adsorbate on the surface of the sample by vacuuming.

Abstract: A power supply circuit includes at least two input terminals that receive an input voltage, a transformer including a primary side electrically connected to the input voltage, a rectifier electrically connected to a secondary side of the transformer, and a boost switch electrically connected in parallel with the rectifier and a pair of output voltage terminals that include a first output voltage terminal and a second output voltage terminal. The input voltage is electrically connected to an AC source, and each of the at least two input terminals receives a different phase of the AC source.

Abstract: Provided are aromatic oligoamide foldamers and self-assembled compositions of the same. The aromatic oligoamide foldamers and compositions can form tube-like structures that can form pores in membranes. The pores can be used to transport ions and molecules, such as, for example, cryoprotective agents or therapeutic agents, through the membrane. The tube-like structures exhibit desirable stability at low temperatures.

Abstract: A method of generating content information that matches at least one stored keyword is described. At least one keyword associated with content information is stored. At least one previously searched keyword in a search record is matched with the at least one stored keyword associated with the content information. First-category mapping data is generated based on a first mapping between the matched at least one stored keyword and the at least one previously searched keyword. Second-category mapping data is generated based on the content information and the at least one stored keyword. A received target keyword is determined to be included in the first-category mapping data. In response to the received target keyword, which is included in the first-category mapping data, circuitry of a terminal searches for the content information associated with the target keyword in the second-category mapping data and displays the content information.

Abstract: A power supply circuit includes a matrix converter that converts a first to third input alternating current (AC) phases into a single primary phase, a transformer including a primary side electrically connected to the single primary phase, a rectifier electrically connected to a secondary side of the transformer, and an output voltage terminal electrically connected to the rectifier. The matrix converter includes first through sixth bi-directional switch pairs, and each of the first through sixth bi-directional switch pairs includes first and second uni-directional switches. When the third input AC phase is disconnected or short circuited, the second and the fifth bi-directional switch pairs are turned off, and, in each of the first, third, fourth, and sixth bi-directional switch pairs, one of the first and second uni-directional switches are turned on and the other of the second and first uni-directional switches are operated as a full-bridge phase-shifted converter.

Abstract: The present invention provides a display module and a fixing method therefor, and a display apparatus. The display module is provided with a light-shielding structure including a light-shielding part and a supporting part that are integrally formed, wherein the light-shielding part is arranged around the inner wall of a through hole; the supporting part is fixed to a side of a display panel away from a cover plate; and an orthographic projection of the light-shielding part on the cover plate and an orthographic projection of a light-shielding layer on the cover plate at least partially overlap, such that a transition area is surrounded by the light-shielding layer and the light-shielding part in a through hole area.

Abstract: Genetically engineered antibodies containing non-native N-glycosylated sites, preparation of the antibodies in yeast and fungi, site-specific conjugation of drugs to these antibodies, and methods of treatment utilizing these antibodies are described herein.

Abstract: A transformer assembly includes a top core, a bottom core under the top core, a primary winding that is multi-layered and that extends around each of the top core and the bottom core, and a secondary winding that is multi-layered and that extends around each of the top core and the bottom core. The primary winding extends around the top core and the bottom core such that, when current flows in the primary winding, magnetic flux is canceled or substantially canceled in a region between the top core and the bottom core. A converter assembly includes the transformer assembly, a primary-side circuit including the primary windings, and a secondary-side circuit including the secondary windings.

Abstract: A power supply circuit includes a first direct-current to direct-current (DC-DC) converter circuit connected to a first load via a first bidirectional switch; a second DC-DC converter circuit connected to a second load and connected, via a second bidirectional switch, to the first load; and a control circuit that turns ON and turns OFF the first bidirectional switch and the second bidirectional switch in a complementary manner.

Abstract: Genetically engineered antibodies containing non-native N-glycosylated sites, preparation of the antibodies in yeast and fungi, site-specific conjugation of drugs to these antibodies, and methods of treatment utilizing these antibodies are described herein.

Abstract: A power factor correction converter that outputs a DC output voltage from an AC input voltage, includes two channels each including a high-side switch and a low-side switch connected in cascade between a positive output terminal and a negative output terminal of the power factor correction converter and with a node between the high-side switch and the low-side switch; an inductor connected to a first terminal of the AC input voltage and the first node; a gate driver connected to the second high-side switch and the second low-side switch; a bootstrap circuit connected to the second node and the gate driver; wherein the second node is connected to a second terminal of the AC input voltage; and the bootstrap circuit is pre-charged at beginnings of negative half-cycles of the AC input voltage.

Abstract: A device for enriching and purifying a single gas in a mixed gas includes: a pre-purification cold trap for freezing and adsorbing part of non-target gases; an enrichment cold and hot trap, having molecular sieves of different specifications detachably filled therein, a gas inlet thereof connected to a gas outlet of the pre-purification cold trap; a freezing unit for reducing a temperature of the enrichment cold and hot trap; a vacuum acquisition system for enabling the enrichment and purification device to reach a preset vacuum degree and exhausting other unabsorbed non-target gases out of the enrichment cold and hot trap, having a suction connected to a gas outlet of the enrichment cold and hot trap; a heating unit for heating the enrichment cold and hot trap to completely release the absorbed target gas; and a purification outlet connected to the gas outlet of the enrichment cold and hot trap.

Abstract: A sample feed device is provided, including: a body; a sample tray provided on the body; a moving part provided on the body and capable of reciprocating on the body, and the moving part provided with a transfer chamber, the transfer chamber capable of receiving a sample from the sample tray and transferring the sample to an analyzer with the movement of the moving part; a processing system provided on the body, and capable of performing helium gas purging and vacuum processing to the sample. The sample feed device may feed the sample automatically through relay transfer of the sample by the sample tray and the moving part. The processing system may perform the helium gas purging and vacuuming to the sample, which strips adsorbate on the surface of the sample by the helium gas purging, and removes the stripped adsorbate on the surface of the sample by vacuuming.