Abstract: This application relates to training a prediction model that includes: pre-training a first prediction model based on a plurality of first sample whole genome sequences to obtain a second prediction model; extracting a target dinucleotide site from a plurality of dinucleotide sites of each first sample whole genome sequence, and taking a sequence within a preconfigured window range including the target dinucleotide site as a second sample whole genome sequence; annotating an actual methylation status for the target dinucleotide site in each second sample whole genome sequence; and performing training processing on the second prediction model based on each annotated second sample whole genome sequence to obtain a trained third prediction model, the third prediction model being configured to predict a methylation status of a dinucleotide site in a to-be-detected whole genome sequence.

Abstract: A data classification method, apparatus, and computer-readable storage medium for early-stage cancer diagnosis using biological parameter analysis. The method acquires object data containing biological state parameter values for a classification object and candidate data from multiple reference objects. Feature information is extracted from both object and candidate data. Target candidate data satisfying correlation conditions with the object data is selected, and object feature information is adjusted using the selected candidate features. The adjusted features are classified to generate probability reference values indicating likelihood of belonging to preset cancer classifications. Results are displayed as diagnostic references for early-stage cancer detection. This approach enables personalized cancer risk assessment through comparative analysis of biological parameters against reference populations with feature correlation-based refinement.

Abstract: The present invention relates to formulations comprising an immunoconjugate of a recombinant anti-programmed death receptor 1 (PD-1) antibody and a mutant interleukin-2 (IL-2) (also referred to as “?PD-1/IL2m”), particularly stable liquid formulations, as well as methods for preparing said formulations, and the use of said formulations for the treatment and/or prevention of diseases.

Abstract: The present invention relates to a formulation comprising a bispecific binding molecule binding to VEGF and Ang2 and uses thereof, and in particular to a pharmaceutical formulation comprising the bispecific binding molecule, a buffer, a stabilizer, and a surfactant. Furthermore, the present invention further relates to therapeutic or prophylactic use of these formulations.

Abstract: A method for training a ligand information generation model performed by an electronic device includes obtaining sample receptor information and sample ligand information, a binding affinity between a ligand described by the sample ligand information and a receptor described by the sample receptor information being not less than a set affinity; denoising reference noise data based on the sample receptor information using a neural network model undergoing training to obtain predicted ligand information; determining a first loss for characterizing a difference between the sample ligand information and the predicted ligand information; and training the neural network model based on the first loss to obtain a ligand information generation model, the ligand information generation model being configured to generate reference ligand information based on reference receptor information.

Abstract: This application provides an image classification method and apparatus, an electronic device, a computer-readable storage medium, and a computer program product. The method includes: obtaining a to-be-classified image including a plurality of to-be-classified sub-images, and converting the to-be-classified image between different modalities, to obtain modality information of the to-be-classified image that corresponds to each modality; performing modality fusion on all pieces of modality information, to obtain a multimodal vector corresponding to the to-be-classified image; encoding the to-be-classified image based on the multimodal vector, to obtain a to-be-classified sub-vector in a one-to-one correspondence with each to-be-classified sub-image; and classifying the to-be-classified image based on the to-be-classified sub-vector corresponding to each to-be-classified sub-image, to obtain the category of the to-be-classified image.

Abstract: A nickel oxyhydroxide/carbon nanotube composite for a water-based magnesium ion positive electrode material, and a preparation method and use thereof are provided. In this approach, carbon nanotubes serve as substrates onto which nickel oxyhydroxide particles are grown via a chemical bath method, yielding the desired composite. By employing this technique, nickel oxyhydroxide nanoparticles are synthesized directly on the surface of carbon nanotubes through a simple chemical bath process, resulting in the formation of a composite structure. This composite material, utilized as a cathode electrode in water-based magnesium ion batteries, exhibits outstanding electrochemical performance, particularly in terms of cycling stability and magnesium ion storage capacity.

Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.

Abstract: A method, apparatus, and computer-readable storage medium for predicting the affinity of an antibody sequence for an antigen sequence. The method includes obtaining antigen sequence information and antibody sequence information comprising light chain and heavy chain sequence information. Sequence features are extracted from the antigen sequence, light chain sequence, and heavy chain sequence. These extracted features are fused to obtain fused sequence features, which are then processed using a fully connected neural network. The processing determines an affinity detection result representing the affinity of the antibody sequence for the antigen sequence. This computational approach enables efficient prediction of antibody-antigen binding affinities for applications in therapeutic antibody development and immunological research.

Abstract: A forward and reverse cleaning brush with water spraying function, comprising a shell, a water spraying heating mechanism, a power mechanism, a transmission component and a cleaning brush disc, wherein the water spraying heating mechanism is arranged in the shell, the power mechanism is arranged in the shell, the transmission component is arranged at the front end of the shell, and the front end of the transmission component extends out of the shell, the cleaning brush disc is detachably arranged at the front end of the transmission component, the power mechanism and the transmission component cooperate to drive the cleaning brush disc to rotate.

Abstract: An immunogenicity prediction model training method includes constructing an immunogenicity prediction model that includes a binding prediction sub-model, a presentation prediction sub-model, and an immunogenicity prediction sub-model, the binding prediction sub-model being configured to predict binding between an epitope and a major histocompatibility complex (MHC), the presentation prediction sub-model being configured to predict cell membrane presentation of an antigenic peptide-major histocompatibility complex (pMHC) molecular complex, and the immunogenicity prediction sub-model being configured to predict immunogenicity of the pMHC; inputting a first sample pair into the immunogenicity prediction model to obtain a sample immunogenicity prediction result, the first sample pair including a first sample epitope sequence and a first sample MHC sequence, and the first sample pair being provided with a first sample immunogenicity label; and training the immunogenicity prediction model with the first sample immu

Abstract: Provided are an adaptive control electromagnetic induction energy harvesting method and system for a power transmission line.

Abstract: The present disclosure relates to an integrated hydraulic power device and a fire truck. The integrated hydraulic power device includes: an integrated valve including a valve body having an internal flow passage structure, a first mounting end and a second mounting end; a motor fixedly arranged at the first mounting end; a hydraulic oil tank fixedly arranged at the second mounting end; and a hydraulic pump located within the hydraulic oil tank and in drive connection with the motor, wherein the hydraulic pump has an oil suction port for drawing oil from the hydraulic oil tank, and the internal flow passage structure is communicated with the hydraulic oil tank and the hydraulic pump.

Abstract: An anti-collision simulation device and a radiotherapy system relate to the technical field of medical equipment. The anti-collision simulation device is applied to a radiotherapy device, and includes a supporting frame and a simulation rod rotatably connected to the supporting frame. A space enclosed by a rotation track of the simulation rod is matched with a space in a therapy cabin of the radiotherapy device. The supporting frame includes a fixing frame and a movable frame. The fixing frame is fixedly installed relative to the radiotherapy device. The simulation rod is rotatably connected to the movable frame, and the movable frame is able to move relative to the fixing frame, so as to enable the simulation rod to be located at different positions.

Abstract: The application provides a modification of gas density relay, a gas density relay with online self-check function and its check method for high-voltage and medium-voltage electrical equipment. The gas density relay includes a gas density relay body, a gas density sensor, a pressure regulating mechanism, a valve, an online check contact signal sampling unit and an intelligent control unit. The pressure is increased or decreased by the pressure regulating mechanism to enable the contact action of the gas density relay body. The contact action is transmitted to the intelligent control unit through the online check contact signal sampling unit. The intelligent control unit detects the alarm and/or blocking contact signal operating value and/or return value of the gas density relay body according to the density value of the contact action; the check of the gas density relay can be completed without maintenance personnel on site.

Abstract: An integrated valve is made by a method for designing and manufacturing a valve body of the integrated valve. The method for designing the valve body of the integrated valve includes: determining an internal flow channel structure of a valve body model of the integrated valve according to a hydraulic function implemented by the integrated valve; determining a position and a size of respective mounting structures, matched with the external devices, in the valve body model; determining a work structure of the valve body model according to the internal flow channel structure, and the position and the size of respective mounting structures; determining an internal connection plane of the valve body model, and determining an internal supporting table; and determining an external shell of the valve body model, and connecting the external shell with the work structure and the internal supporting table.

Abstract: The present disclosure relates to an integrated hydraulic power device and a fire truck. The integrated hydraulic power device includes: an integrated valve including a valve body having an internal flow passage structure, a first mounting end and a second mounting end; a motor fixedly arranged at the first mounting end; a hydraulic oil tank fixedly arranged at the second mounting end; and a hydraulic pump located within the hydraulic oil tank and in drive connection with the motor, wherein the hydraulic pump has an oil suction port for drawing oil from the hydraulic oil tank, and the internal flow passage structure is communicated with the hydraulic oil tank and the hydraulic pump.

Abstract: A device for realizing the splicing of an array fiber and a large-size quartz end cap comprises a carbon dioxide laser, a light splitter, a light beam shaper, a high reflectivity mirror, an image detection module, an array fiber and a carrier thereof, a large-size quartz end cap and a carrier thereof, a stepping motor, a thermodetector, and a computer; a laser beam emitted by the carbon dioxide laser is divided into two light beams through a light splitter, after the two light beams respectively pass through the beam shaper and the high reflectivity mirror, two strip-shaped light spots with uniform power density are integrally formed to heat a splicing face of the large-size quartz end cap, a uniform temperature field of a target splicing area is achieved through indirect heating and heat conduction.