Patents by Inventor Bing Huang

Bing Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250158274
    Abstract: Provided is a device for enabling a mobile communication terminal to exchange information underwater through electromagnetic waves, including an electromagnetic wave transceiver unit, a cable take-up reel, and a fixing support, wherein the electromagnetic wave transceiver unit is configured to achieve the wireless information interaction between the device and the intelligent mobile terminal through an antenna contained therein; the cable take-up reel is configured to realize the retraction and release of a cable, fix the antenna and make same rotate synchronously with the cable take-up reel; and the fixing support is configured to maintain a fixed relative position between the intelligent mobile terminal and the device.
    Type: Application
    Filed: November 7, 2024
    Publication date: May 15, 2025
    Inventors: Songdong LIU, Jinsong LIU, Zhili CHEN, Duo QIN, Bing HUANG, Kai ZHANG
  • Publication number: 20250158272
    Abstract: The present disclosure relates to a water surface floating type electromagnetic wave signal relay device, includes: a central processing mechanism, including a first waterproof housing, and a control circuit board and a power supply assembly arranged inside the first waterproof housing, the power supply assembly being connected to the control circuit board; an antenna mechanism, including a second waterproof housing and an antenna assembly arranged inside the second waterproof housing, the second waterproof housing being hermetically assembled and connected to the first waterproof housing, and the antenna assembly being in signal connection with the control circuit board; and a floating mechanism, including three or more floating units, the three or more floating units being distributed around the central processing mechanism in an annular array, and each of the floating units being connected to the first waterproof housing of the central processing mechanism in a stretchable and/or foldable manner.
    Type: Application
    Filed: November 7, 2024
    Publication date: May 15, 2025
    Inventors: Songdong LIU, Jinsong LIU, Zhili CHEN, Duo QIN, Bing HUANG, Kai ZHANG
  • Publication number: 20250133014
    Abstract: Provided in the embodiments of the present disclosure are a routing method and apparatus, a cloud resource registering method and apparatus, and a storage medium and an electronic apparatus.
    Type: Application
    Filed: June 15, 2022
    Publication date: April 24, 2025
    Inventors: Guangping HUANG, Bin TAN, Shaofu PENG, Yong GUO, Bing HUANG
  • Publication number: 20240067748
    Abstract: An isolated monoclonal antibody capable of specifically binding to Trop2 is provided, together with a nucleic acid molecule encoding the antibody, as well as an expression vector, a host cell, and a method for expressing the antibody. An immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus, and a pharmaceutical composition containing the antibody, and a diagnostic or therapeutic method using the antibody are also provided.
    Type: Application
    Filed: December 28, 2021
    Publication date: February 29, 2024
    Inventors: Qiang LV, Bing HUANG, Yiping RONG
  • Patent number: 11831598
    Abstract: The present disclosure provides a method, apparatus and system for switching a virtual IP, relates to the field of artificial intelligence and particularly to cloud computing and cloud network technologies, and can be applied to intelligent cloud scenarios. A detailed implementation comprises: receiving a free ARP packet sent by a virtual machine to which a high-availability virtual IP is successfully switched; generating a first forwarding table of the high-availability virtual IP according to the free ARP packet; encapsulating the first forwarding table in a first UDP packet by VXLAN; and synchronizing the first UDP packet to another virtual router.
    Type: Grant
    Filed: December 7, 2022
    Date of Patent: November 28, 2023
    Assignee: BEIJING BAIDU NETCOM SCIENCE, TECHNOLOGY CO., LTD.
    Inventors: Yong Shao, Peilong Wang, Qingzhi Zhou, Bing Huang, Lanlan Pan
  • Publication number: 20230322953
    Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 12, 2023
    Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTD
    Inventors: Yun HE, Lei SHI, Haishan LUO, Qiang LV, Jinqiu HE, Zenglin PEI, Yongqiang WANG, Chen ZHONG, Bing HUANG, Jianxun ZHAO, Xingxing JIA, Xuekun ZHANG, Chuchu ZHAO, Fei CHEN, Lei NIU
  • Publication number: 20230303698
    Abstract: The present invention provides a binding protein and use thereof, wherein the binding protein comprises a first protein functional region binding to a targeting moiety of an antigen on a target cell, and a second protein functional region binding to an effector moiety of an antigen on an immune effector cell; and the binding protein is selected from the following structure: the first protein functional region is of a Fab structure, the second protein functional region is of a VH structure or a Fab structure, and the first protein functional region and the second protein functional region are arranged sequentially from the N-terminus to the C-terminus of the binding protein. The binding protein can bring the immune effector cell and the specific target cell together, efficiently and selectively activate the immune effector cell in a microenvironment of the specific target cell, further enhance immune responses, and reduce toxic and side effects caused by non-specific activation of peripheral immune cells.
    Type: Application
    Filed: June 29, 2021
    Publication date: September 28, 2023
    Inventors: Yun HE, Lei SHI, Xiaodong WU, Chen ZHONG, Bing HUANG, Yiping RONG
  • Publication number: 20230295324
    Abstract: An OX40-targeted antibody or an antigen binding fragment thereof. The OX40-targeted antibody comprises a VH. The VH comprises the following CDRs or mutants thereof: a VH CDR1 as shown in an amino acid sequence of SEQ ID NO: 10, a VH CDR2 as shown in an amino acid sequence of SEQ ID NO: 44, and/or a VH CDR3 as shown in an amino acid sequence of SEQ ID NO: 86, SEQ ID NO: 84, or SEQ ID NO: 89. Also disclosed is a preparation method, an application, and a double-antibody comprising same. The antibody or the antigen binding fragment thereof can specifically bind to OX40, promote larger activation of NF-Kb, activate OX40 pathways in vitro, and induce activation of T cell function. The double-antibody can identify tumor target TAA, can bind to OX40 on the T cell, and can recruit and activate T cells near tumor cells to kill tumor cells.
    Type: Application
    Filed: June 29, 2021
    Publication date: September 21, 2023
    Inventors: Lei SHI, Bing HUANG, Jian WANG, Xingxing JIA
  • Publication number: 20230287143
    Abstract: Provided is a binding protein, which comprises a protein functional region A and a protein functional region B, both of which target different antigens or different epitopes of antigens. The protein functional region A is Fab; the protein functional region B is VH; and the binding protein also comprises an Fc homodimer. There are two of both the protein functional region A and the protein functional region B. The binding protein has a left-right symmetrical structure. The binding protein consists of the protein functional region A, the protein functional region B and Fc in sequence from the N-terminus to the C-terminus, wherein the protein functional region A and the protein functional region B are connected by means of L1, and the protein functional region B is connected to the Fc by means of L2. The binding protein has a relatively small molecular mass, few polypeptide chains and a simpler structure. The protein has a versatile structure and may be applied to a variety of different target combinations.
    Type: Application
    Filed: June 29, 2021
    Publication date: September 14, 2023
    Inventors: Yun HE, Lei SHI, Bing HUANG, Chen ZHONG, Qiang LV, Ming WANG
  • Patent number: 11744055
    Abstract: An electrically conductive multilayer film for providing an electrical path between two conductive surfaces includes a plastic backing layer, an electrically conductive layer disposed on a first side of the plastic backing layer, and a recovery layer disposed on an opposite second side of the plastic backing layer. An average thickness of the multilayer film is less than about 100 microns. A hollow gasket can be formed from the multilayer film by winding or bending the multilayer film into a flexible hollow closed loop. When the multilayer film is wound to form a flexible closed loop having an outside diameter of no more than about 7 mm with the conductive layer forming an outside layer of the loop, a resistance of the closed loop across a diameter of the closed loop remains less than about 2? when the loop is compressed across the diameter by at least 20%.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: August 29, 2023
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Bing Huang, Su Zhang, Xin Zhang, Jing Fang, Fan Gao
  • Publication number: 20230253145
    Abstract: A reactor, comprising: a support; a coil wound on an outer surface of the support and including a plurality of coil segments electrically connected in sequence; and at least one first insulating separator disposed on the outer surface of the support and separating the outer surface of the support into a plurality of regions, in which the plurality of coil segments is respectively arranged.
    Type: Application
    Filed: February 9, 2023
    Publication date: August 10, 2023
    Applicant: ABB E-mobility B.V.
    Inventors: Yijie Cen, Bing Huang, ZhiYong Lv
  • Publication number: 20230242658
    Abstract: The present invention discloses a 4-1BB-binding protein and use thereof. The 4-1BB-binding protein comprises a heavy chain variable region, wherein the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, wherein the HCDR1 comprises a sequence as set forth in SEQ ID NO: 15 or a variant 1 thereof, or SEQ ID NO: 16; the HCDR2 comprises a sequence selected from SEQ ID NO: 60 or a variant 2 thereof, and SEQ ID NO: 50 or a variant 4 thereof; the HCDR3 comprises a sequence as set forth in SEQ ID NO: 103 or a variant 3 thereof, SEQ ID NO: 333 or a variant 5 thereof, SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 116, SEQ ID NO: 326, SEQ ID NO: 331, SEQ ID NO: 334 or SEQ ID NO: 96. The 4-1BB-binding protein of the present invention is a fully human antibody having the binding activity to human 4-1BB and cynomolgus monkey 4-1BB. Some 4-1BB-binding proteins are only half the size of conventional IgG antibodies; they can be well used for bispecific antibodies.
    Type: Application
    Filed: June 29, 2021
    Publication date: August 3, 2023
    Applicant: NONA BIOSCIENCES (SUZHOU) CO., LTD.
    Inventors: Lei SHI, Bing HUANG, Yun HE, Xin GAN, Fei CHEN, Jianxun ZHAO, Bo XIANG
  • Publication number: 20230235090
    Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.
    Type: Application
    Filed: June 29, 2021
    Publication date: July 27, 2023
    Applicant: HARBOUR BIOMED US, INC.
    Inventors: Lei SHI, Chen ZHONG, Xiaodong WU, Yun HE, Fei CHEN, Xiaocheng LV, Jinli XIE, Yiping RONG, Bing HUANG, Fangfang DU, Jianxun ZHAO
  • Publication number: 20230131871
    Abstract: A method, system and apparatus for forwarding data in a virtual network, an electronic device, a storage medium and a computer program product are provided. The method includes: determining, in a process of managing virtual private cloud networks through a central control node, all forwarding rules for nodes in the virtual private cloud networks; synchronizing the forwarding rules in a virtual routing cluster, and determining target forwarding rules corresponding to each virtual private cloud network from the forwarding rules; and through a virtual switch in each virtual private cloud network, learning the target forwarding rules corresponding to the virtual private cloud network to which the virtual switch belongs, and performing data forwarding based on the learned target forwarding rules.
    Type: Application
    Filed: December 15, 2022
    Publication date: April 27, 2023
    Applicant: Beijing Baidu Netcom Science Technology Co., Ltd.
    Inventors: Yong SHAO, Zhongshan Liu, Bing Huang, Peilong Wang, Yao Wang, Yan Wang, Fenghui Zhang, Qingzhi Zhou
  • Publication number: 20230111925
    Abstract: The present invention relates to a fibrotic disease mechanism, and a preventive/therapeutic drug and method therefor. The present invention can improve the level of cAMP by means of a PDE inhibitor such as dipyridamole to treat fibrotic diseases and inhibit the progress of fibrosis. The present invention further achieves anti-inflammatory and immune regulation effects, and achieves a therapeutic effect on all aspects of the occurrence and development of fibrosis.
    Type: Application
    Filed: February 9, 2021
    Publication date: April 13, 2023
    Applicant: GUANGZHOU WOMEN AND CHILDREN'S MEDICAL CENTER
    Inventors: Yuxia ZHANG, Yanhui XU, Bing HUANG, Ming LIU, Zhiyao ZHAO, Jun WANG, Zhanghua CHEN, Rongli FANG
  • Publication number: 20230108522
    Abstract: The present disclosure provides a method, apparatus and system for switching a virtual IP, relates to the field of artificial intelligence and particularly to cloud computing and cloud network technologies, and can be applied to intelligent cloud scenarios. A detailed implementation comprises: receiving a free ARP packet sent by a virtual machine to which a high-availability virtual IP is successfully switched; generating a first forwarding table of the high-availability virtual IP according to the free ARP packet; encapsulating the first forwarding table in a first UDP packet by VXLAN; and synchronizing the first UDP packet to another virtual router.
    Type: Application
    Filed: December 7, 2022
    Publication date: April 6, 2023
    Inventors: Yong SHAO, Peilong WANG, Qingzhi ZHOU, Bing HUANG, Lanlan PAN
  • Patent number: 11510949
    Abstract: The present invention relates to the use of a novel Lactobacillus brevis ProGA28 strain, deposited in the German Collection for Microorganisms and Cell Cultures (DSMZ) under the accession number DSM 33167 on May 28, 2019. The metabolites of Lactobacillus brevis ProGA28 have the ability to improve sleep quality, can effectively reduce the time of rapid eye movement in the sleep phase, can reduce time to fall asleep, can increase total sleep time, and can increase the ratio of low waves during sleep so that sleep disorders and related complications, such as anxiety and immune system diseases, are treated.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: November 29, 2022
    Assignee: SYNGEN BIOTECH CO., LTD
    Inventors: Wei-Jen Chen, Bing-Huang Gau, Po-An Chen, Yu-Shan Wei
  • Patent number: 11444861
    Abstract: Embodiments of the present disclosure relate to a method and apparatus for detecting traffic. The method includes: acquiring traffic information of at least two dimensions of a target IP; determining whether the traffic information of the at least two dimensions contains traffic information exceeding an abnormal traffic threshold of a corresponding dimension of the target IP; and in response to determining that the traffic information of the at least two dimensions contains the traffic information exceeding the abnormal traffic threshold of the corresponding dimension, determining that the traffic of the target IP is abnormal.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: September 13, 2022
    Assignee: Beijing Baidu Netcom Science and Technology Co., Ltd.
    Inventors: Yajing Chen, Bing Huang, Qingzhi Zhou, Shaoyan Wang
  • Publication number: 20220260566
    Abstract: The present invention relates to gastrointestinal diseases, such as non-infectious gastrointestinal diseases, including the immune mechanism of non-infectious gastrointestinal diseases in children, and the use of phosphodiesterase inhibitors and/or antiplatelet drugs in the treatment of gastrointestinal diseases such as non-infectious gastrointestinal diseases.
    Type: Application
    Filed: November 15, 2019
    Publication date: August 18, 2022
    Applicant: GUANGZHOU WOMEN AND CHILDREN'S MEDICAL CENTER
    Inventors: Yuxia ZHANG, Min YANG, Bing HUANG, Zhanghua CHEN, Li ZHANG, Fan BAI, Sitang GONG
  • Patent number: D961826
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: August 23, 2022
    Inventor: Bing Huang