Patents by Inventor Bing L. Lam

Bing L. Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4675406
    Abstract: This invention relates to substituted 4-pyrimidinones which are useful as intermediates in preparing H.sub.2 -antagonists.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: June 23, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Patent number: 4620001
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: September 11, 1984
    Date of Patent: October 28, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Patent number: 4477663
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: April 7, 1982
    Date of Patent: October 16, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Patent number: 4352933
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: February 6, 1981
    Date of Patent: October 5, 1982
    Assignee: Smithkline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Patent number: 4340733
    Abstract: A process for preparing 3-chloro-6-(2-hydroxyphenyl)pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing compounds which have .beta.-adrenergic blocking and vasodilator activity and are useful as antihypertensive agents.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: July 20, 1982
    Assignee: SmithKline Corporation
    Inventor: Bing L. Lam
  • Patent number: 4251660
    Abstract: A method for preparing 1,2,3,4-tetrahydroisoquinolines comprising heating N-halo or hydroxyethyl-N-benzylamines in an aluminum chloride melt at 160.degree.-210.degree..
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: February 17, 1981
    Assignee: SmithKline Corporation
    Inventors: Bing L. Lam, Wilford L. Mendelson, Charles B. Spainhour, Jr.
  • Patent number: 4006169
    Abstract: A method of preparing .alpha.,.beta.-epoxy ketones by reacting water-soluble .alpha.,.beta.-ethylenic ketones with sodium hypochlorite. Especially useful for preparing 3,4-epoxy-butanone.
    Type: Grant
    Filed: February 26, 1976
    Date of Patent: February 1, 1977
    Assignee: SmithKline Corporation
    Inventors: Elvin L. Anderson, Bing L. Lam, George R. Wellman