Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A battery securing component configured to be mounted on a vehicle body is provided. A battery is vertically disposed on the vehicle body. The battery securing component includes: a lifting column vertically arranged on a side of the battery, and a lower end of the lifting column being threadedly connected to the vehicle body to cause the lifting column to be capable of moving up and down by rotating; a pressing sleeve rotatably sleeved on the lifting column and configured to be moved up and down in synchronization with the lifting column; a pressing arm being formed on the pressing sleeve by protruding toward the battery, higher than the battery) and an elastic engaging structure configured to drive the pressing sleeve to rotate in synchronization with the lifting column, and arranged between the pressing sleeve and the lifting column.

Abstract: The present invention provides a massage device, comprising: a massaging head; an eccentric wheel with a shaft hole; a driver with a driving shaft that passes in the shaft hole of the eccentric wheel to drive the eccentric wheel rotating; a slider slidably installed in the eccentric wheel; a connecting rod connected to the slider and the massage head whereby the driving shaft drives the slider rotating to take the massaging head moving back and forth by the connecting rod for beating a user' muscle; and a movable seat with a shaft hole for the driving shaft passing through the shaft hole; wherein the slider is radially slidable relative the shaft hole to move close to or away from the driving shaft so as to change an eccentric radium of the eccentric wheel; and accordingly, a movement depth of the massaging head is adjustable.

Abstract: A method and apparatus for determining the cathodic protection effectiveness of a pipeline at trenchless crossing. The method comprises: according to obtained construction parameters of a pipeline at trenchless crossing to be evaluated, determining a soil resistivity corresponding to the pipeline at trenchless crossing to be evaluated, and corresponding polarization potentials at both ends; from a preconstructed polarization potential threshold table of pipeline at trenchless crossing, obtaining a first polarization potential threshold corresponding to the length and soil resistivity in the construction parameters; and according to the polarization potentials at both ends and the first polarization potential threshold corresponding to the pipeline at trenchless crossing to be evaluated, determining the cathodic protection effectiveness of the pipeline at trenchless crossing to be evaluated.

Abstract: The present invention provides a method for treating cancer patients accompanied by pain by combining an AKR1C3-activated anticancer prodrug compound with an analgesic drug, a pharmaceutical use, a drug combination and a pharmaceutical formulation thereof, which provides a reasonable alternative for clinical cancer treatment. In particular, the combination of AST-3424 and non-steroidal analgesic drug can achieve the effect of simultaneously treating cancer and relieving pain.

Abstract: Compounds of the formula I: or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

Abstract: A semiconductor sputtering process equipment is disclosed. The sputtering equipment comprises a cavity, a substrate support for the wafers, a contamination shutter disk and its carrier, and its calibration mechanism. The calibration mechanism is arranged on the cavity. The contamination shutter disk is switched between a first position and a second position by the carrier. When the shutter disk is at the first position, it is away from the substrate support. The calibration mechanism adjusts the shutter disk to a preset position on the carrier. When the shutter disk is at the preset position on the carrier and the carrier drives the shutter disk to move to the second position, the shutter disk is positioned above the substrate support, and a spacing between a first central axis of the shutter disk and a second central axis of the substrate support is less than or equal to a first preset distance.

Abstract: A device and method for installing and adjusting pressure of a roller guide shoe, and an elevator system. The device includes: a bracket, installed on a car frame upright of an elevator car; a positioning portion, installed on the bracket and operatively having a first state in which the positioning portion fixes a positioning of the car frame upright relative to an elevator guide rail to define a reference for installing the roller guide shoe to the car frame upright, and a second state in which the positioning portion releases the positioning; and a pressure adjusting portion, including a contact member installed on the bracket, and a mating member installed at a preset position on the elevator guide rail and located outside a running trajectory of the roller guide shoe on the elevator guide rail.

Abstract: A linker and a use thereof in a ligand drug conjugate. Provided is a compound as represented by formula (III), or a mesomer, a racemate, an enantiomer, a diastereomer or a mixture form thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a pharmaceutically acceptable salt of a solvate thereof. The linker can be selectively coupled with thiols in biomacromolecules, has extremely high coupling efficiency and high drug loading capacity; and also shows high chemical stability.

Abstract: Disclosed is a single-cell manipulation device, including a stage, a probe, a probe control assembly, a microscopic imaging assembly, and a pneumatic pressure source assembly. The pneumatic pressure source assembly is configured to provide positive and/or negative pneumatic pressure to the at least one probe in the form of pulses. A method for extracting single cells, a method for injecting a reagent into a single cell and/or extracting contents from a single cell, and a method for performing sample spotting using the single-cell manipulation device are further disclosed. By providing pulsed positive and negative pneumatic pressure to the probe, the present disclosure not only enables precise in-situ extraction of target cells, but also allows the extracted cells to enter the interior of the probe. Thus, the probe serves as a temporary storage site for cells, enabling continuous extraction of multiple cells and improving operational efficiency.

Abstract: The present disclosure provides antibody drug conjugate platforms comprising a conjugator assembly component, and antibody drug conjugates comprising platform-derived linker-payloads and antibodies or antigen-binding fragments thereof. In some embodiments, an antibody drug conjugate is of the following formula or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein values for the variables (e.g., BA, U, V, A, a?, W, w?, Y, y?, PA, x) are as described herein.

Abstract: Compounds of the following formula (I); or the pharmaceutically acceptable salts thereof, are inhibitors of haematopoietic progenitor kinase 1 (HPK1) useful in the treatment of diseases or disorders associated with HPK1. Also disclosed herein are uses of these compounds in the potential treatment or prevention of an HPK1-associated disease or disorder. Also disclosed herein are compositions comprising one or more of the compounds. Further disclosed herein are uses of these compositions in the potential prevention or treatment of an HPK1-associated disease or disorder.

Abstract: An array substrate, a driving method thereof, and a display device. In the array substrate, rows of sub-pixels include groups of sub-pixels, each group of sub-pixels includes part of the rows of sub-pixels, and charging times of the part of the rows of sub-pixels are overlapped. A charging time of the second part of the plurality of rows of sub-pixels is longer than a charging time of the first part of the plurality of rows of sub-pixels. During a first time period, a same data signal is written into the first part of the plurality of rows of sub-pixels and the second part of the plurality of rows of sub-pixels, and during a second time period, a data signal written into the second part of the plurality of rows of sub-pixels is at least partially the same as the data signal written during the first time period.

Abstract: A massage device having an adjustable massage depth. The massage device comprising a driving device, a crank, a connecting rod, and a massage head assembly, wherein one end of the connecting rod is connected to the crank, and the other end thereof is connected to the massage head assembly; the driving device rotate the crank, and the massage head assembly is driven by means of the connecting rod to perform a massage; and one end of the connecting rod is connected to the crank by means of a movable connecting assembly. The massage device further comprises an adjustment assembly to move the movable connecting assembly, and the movement of the movable connecting assembly enables the distance between the connecting position of the connecting rod and the crank and the rotation center axis to change, so as to adjust the massage depth of the massage head assembly.

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: The present invention provides a beauty instrument, comprising: a housing with vents therethrough as an air inlet or air outlet; a control circuit board in the housing; a light source assembly in the housing and electrically connected with the control circuit board; and a thermoelectric cooling assembly. The thermoelectric cooling assembly comprises: a thermoelectric cooler, a heat sink, a fan, and a heat transfer assembly. The heat transfer assembly comprises a VC or an ALVC or an Aluminum Heat Pipe. The heat transfer assembly is thermally connected between the heat sink and the hot side of thermoelectric cooler. A front end of the beauty instrument has a light outlet surface; the cold side is connected to and cool the light outlet surface, or the cold side serves as the light outlet surface, thereby, the light outlet surface is able to cool skin in contact.

Abstract: A platform for testing the excavation resistance of a small-sized backhoe excavator is provided. The testing platform comprises a bucket, a mechanical arm device, a measuring device, a workbench frame, and a control device. The bucket is hinged to the mechanical arm device, which is fixed on the workbench frame; the control device is electrically connected to the measuring device, data acquired by the measuring device is used to construct a force balance equation, and through force analysis, excavation resistance is obtained.

Abstract: A technique suggests resources within a particular environment. The technique operates by receiving a query via a search interface presentation, and using a prefix tree data structure to retrieve candidate resource descriptors that match the query. The candidate resource descriptors are data items that describe different types of candidate resources. The technique further includes: generating feature information that describes the candidate resource descriptors; using a machine-trained ranking model to generate scores associated with the candidate resource descriptors, based on the feature information; sorting the candidate resource descriptors based on the scores, to provide sorted resource descriptors; and generating output information that represents a selected set of resource descriptors drawn from the sorted resource descriptors, for presentation via the search interface presentation.

Abstract: A tension device for an elevator car, an elevator car, and an elevator system. The elevator car has a first side portion and a second side portion opposite to each other and a rear side portion opposite to a car door, and an elevator counterweight is arranged on a side close to the first side portion, the tension device includes a tension member, and a first end and a second end of the tension member are fixed to a first position and a second position on the elevator car respectively, to provide a first tensile force acting on the elevator car, and the first tensile force is substantially parallel to a longitudinal direction of the elevator car at the top of the elevator car and directed towards the rear side portion.