Abstract: A solid dispersion, a preparation method therefor, and a solid formulation comprising same. The solid dispersion comprises compound A and a pharmaceutically acceptable matrix polymer, wherein the pharmaceutically acceptable matrix polymer includes an enteric high-molecular polymer and a non-enteric high-molecular polymer, and the compound A is 1-{(6-[(1-methyl)-4-pyrazolyl]-imidazo[1,2-a]pyridine)-3-sulfonyl}-6-[(1-methyl)-4-pyrazolyl]-1-hydro-pyrazolo[4,3-b]pyridine. The solid dispersion can significantly improve the solubility and dissolution stability of the compound A, prolong the supersaturation maintenance time of a drug, and further improve the bioavailability of the drug. The in vivo bioavailability of a solid formulation prepared from the solid dispersion meets the requirement of oral administration of the compound A.

Abstract: A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Abstract: Disclosed are a fabrication method for a superconducting circuit and a superconducting quantum chip. The fabrication method includes: determining, on a substrate, a first junction region located between a first electrical element and a second electrical element, and a second junction region located between a first conductive plate and a second conductive plate that are formed in advance; forming a Josephson junction in the second junction region; detect an electrical parameter of the Josephson junction, and determining whether the electrical parameter is within a target parameter range; if yes, separating the Josephson junction through cutting, and moving the Josephson junction to the first junction region; and forming a first connection structure connecting the first superconducting layer to the first electrical element and a second connection structure connecting the second superconducting layer to the second electrical element.

Abstract: An anti-twist structure of voice coil motor includes a base, a lens housing, an elastic sheet, a magnet, and a yoke member. The lens housing has a margin wall, and the margin wall has a first protrusion and a contact portion. The elastic sheet has a hollowed slot, and the first protrusion pass through the hollowed slot, so that the elastic sheet is disposed on a portion of the margin wall and on the contact portion. The yoke member has an upper wall and a side wall. The side wall is disposed at one side of the upper wall and the side wall extends outward in a direction not parallel to the upper wall. The yoke member surrounds the lens housing, the elastic sheet, and the magnet. The lens housing has a deflectable angle relative to a horizontal reference line.

Abstract: A coupled medium-low temperature flue gas processing apparatus for fly ash washing includes a reactor and scraping rings. In the present disclosure, arranging the scraping rings can scrape the fly ash adhered to the inside of the reactor and bring the scraped fly ash into a mixing liquor to prevent the fly ash from adhering and accumulating, which not only results in the decrease of the fly ash content participating in the reaction, and the difficulty to react with water completely, but also the fly ash adhered to the inside of the reactor will form a thick object after mixing with the water, once the thick object is dried, the adhesive capacity thereof is greatly enhanced.

Abstract: A correlative finding between increased Clostridiales and/or Bifidobacteriales bacterial abundance in the gut and intestinal barrier maturation of preterm neonates at-risk for development of necrotizing enterocolitis (NEC) is disclosed. These findings form the basis for the methods of identifying preterm infants at risk for developing necrotizing enterocolitis (NEC), the methods of treating such infants, as well as the methods of characterizing intestinal permeability in preterm infants disclosed herein.

Abstract: Disclosed are a low-frequency band dipole unit, a multi-frequency band array antenna and an adjustment method therefor. The low-frequency band dipole unit includes a first microstrip dipole arm (1), a second microstrip dipole arm (2) and a support structure (3). The first microstrip dipole arm (1) and the second microstrip dipole arm (2) are each in a T-shaped thin arm structure with two vertical arms upwards, each have a thickness in the order of millimeters, and are each in a straight line when viewed from above. The support structure (3) has a slot structure for clamping and supporting the first microstrip dipole arm (1) and the second microstrip dipole arm (2). The multi-frequency band array antenna has a plurality of columns and/or quasi-columns therein, and at least one column or quasi-column of the plurality of columns and/or quasi-columns is composed of the foregoing low-frequency band dipole units completely.

Abstract: A processing apparatus for removing dioxin in fly ash from domestic waste incineration by using a ball mill includes a grinder as well as a feeding body and a discharging body that are separately arranged at both ends of the grinder. In the present disclosure, an induction coil is electrified by arranging a heating body to generate an alternating magnetic field such that eddies generate on an inner wall of a grinding cylinder in the induction coil, the grinding cylinder is heated by the energy of these eddies, making a grinding ball thermally desorb and decompose a harmful component, that is, dioxin in the fly ash through a high temperature when grinding the fly ash from the domestic waste incineration since a temperature in the grinding cylinder reaches 300-500° C. during grinding.

Abstract: A processing apparatus for treating acid mine wastewater using an activated carbon-loaded microorganism includes a purifying container, a reducing body and an oxygen consumption body. By arranging a fuel gas body, a bottom of a cover disc is in threaded connection with a top of a top pipe after red phosphorus in a bottom cylinder is ignited, air in a feeding chamber enters into the bottom cylinder through gas ports, the oxygen in the air is consumed as the red phosphorus continues to burn, such that an interior of a reaction bin is in an oxygen-free environment, for ease of the microorganism performing the biological reduction reaction on the acid mine wastewater.

Abstract: A processing apparatus for treating acid mine wastewater using an activated carbon-loaded microorganism includes a purifying container, a reducing body and an oxygen consumption body. By arranging a fuel gas body, a bottom of a cover disc is in threaded connection with a top of a top pipe after red phosphorus in a bottom cylinder is ignited, air in a feeding chamber enters into the bottom cylinder through gas ports, the oxygen in the air is consumed as the red phosphorus continues to burn, such that an interior of a reaction bin is in an oxygen-free environment, for ease of the microorganism performing the biological reduction reaction on the acid mine wastewater.

Abstract: A voice coil motor includes a base, a lens housing, a voice coil, a magnet, a first elastic sheet, a second elastic sheet and a yoke member. The lens housing has a first margin wall, and a first protrusion and a second protrusion extend from the first margin wall. The height of the second protrusion is lower than the height of the first protrusion. The yoke member has a first wall, a connection wall, a second wall, and a side wall. The first wall, the connection wall, and the second wall together form a stepped structure. The first wall is disposed on the first protrusion, and the second wall is disposed on the second protrusion. The lens housing has a deflectable angle relative to a horizontal reference line. When the lens housing deflects to a maximum value of the deflectable angle, the second protrusion abuts against the second wall.

Abstract: A voice coil motor includes a base, a lens housing, a voice coil, a magnet, an elastic sheet, and a yoke member. The lens housing has a first margin wall, and a first protrusion and a second protrusion extend from the first margin wall. The height of the second protrusion is lower than the height of the first protrusion. The yoke member has a first wall, a connection wall, a second wall, and a side wall. The first wall, the connection wall, and the second wall together form a stepped structure. The first wall is disposed on the first protrusion, and the second wall is disposed on the second protrusion. The lens housing has a deflectable angle relative to a horizontal reference line. When the lens housing deflects to a maximum value of the deflectable angle, the second protrusion abuts against the second wall.

Abstract: A voice coil motor includes a base, a lens housing, a voice coil, a magnet, and a yoke member. The lens housing has a first margin wall, and a first protrusion and a second protrusion extend from the first margin wall. The height of the second protrusion is lower than the height of the first protrusion. The yoke member has a first wall, a connection wall, a second wall, and a side wall. The first wall, the connection wall, and the second wall together form a stepped structure. The first wall is disposed on the first protrusion, and the second wall is disposed on the second protrusion. The lens housing has a deflectable angle relative to a horizontal reference line. When the lens housing deflects to a maximum value of the deflectable angle, the second protrusion abuts against the second wall.

Abstract: A production device for preparing a building material using a fine particle silt in iron tailings includes an operation desk and a grinding device. During movement of edge plates, gears are located inside a side groove and keep meshing with toothed grooves, the edge plates will drive various gears to rotate along a same direction and drive grinding balls and connecting shafts to rotate while moving, the grinding balls will perform grinding treatment on the fine particle silt at the inner end of the grinding cabinet while rotating.

Abstract: An anti-twist structure of voice coil motor includes a base, a lens housing, an elastic sheet, a magnet, and a yoke member. The lens housing has a margin wall, and the margin wall has a first protrusion and a contact portion. The elastic sheet has a hollowed slot, and the first protrusion pass through the hollowed slot, so that the elastic sheet is disposed on a portion of the margin wall and on the contact portion. The yoke member has an upper wall and a side wall. The side wall is disposed at one side of the upper wall and the side wall extends outward in a direction not parallel to the upper wall. The yoke member surrounds the lens housing, the elastic sheet, and the magnet. The lens housing has a deflectable angle relative to a horizontal reference line.

Abstract: An anti-twist structure of voice coil motor includes a base, a lens housing, an elastic sheet, a magnet, and a yoke member. The lens housing has a margin wall, and the margin wall has a first protrusion and a contact portion. The elastic sheet has a hollowed slot, and the first protrusion pass through the hollowed slot, so that the elastic sheet is disposed on a portion of the margin wall and on the contact portion. The yoke member has an upper wall and a side wall. The side wall is disposed at one side of the upper wall and the side wall extends outward in a direction not parallel to the upper wall. The yoke member surrounds the lens housing, the elastic sheet, and the magnet. The lens housing has a deflectable angle relative to a horizontal reference line.

Abstract: Embodiments of this application disclose a data protection method and system, a medium, and an electronic device, and belong to the field of communication technologies. In embodiments of this application, a first electronic device establishes a communication connection to a second electronic device. The first electronic device is a trusted device of the second electronic device. When detecting a first trigger condition, the first electronic device sends first data to the second electronic device. The first data is used to trigger the second electronic device to enter a maintenance mode. According to embodiments of this application, the first electronic device triggers the second electronic device to enter the maintenance mode, to protect data of the electronic devices.

Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.

Abstract: Disclosed is a combined LED grow lighting system, comprising an LED light track and at least one LED light strip which slidably connects with and longitudinally slides along the LED light track; wherein a remote control signal receiver to receive a remote control signal is configured within the LED light track, a processing device for processing the remote control signal received by the remote control signal receiver to generate a control signal for controlling a power of LED in each LED light strip is connected with each LED light strip, respectively; an LED constant current power supply and a constant current control circuit are configured within the LED light strip, and the constant current control circuit is connected with the processing device and receives the control signal regarding the power of the LED light strip sent from the processing device to control the LED constant current power supply.

Abstract: Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.