Abstract: A solid dispersion, a preparation method therefor, and a solid formulation comprising same. The solid dispersion comprises compound A and a pharmaceutically acceptable matrix polymer, wherein the pharmaceutically acceptable matrix polymer includes an enteric high-molecular polymer and a non-enteric high-molecular polymer, and the compound A is 1-{(6-[(1-methyl)-4-pyrazolyl]-imidazo[1,2-a]pyridine)-3-sulfonyl}-6-[(1-methyl)-4-pyrazolyl]-1-hydro-pyrazolo[4,3-b]pyridine. The solid dispersion can significantly improve the solubility and dissolution stability of the compound A, prolong the supersaturation maintenance time of a drug, and further improve the bioavailability of the drug. The in vivo bioavailability of a solid formulation prepared from the solid dispersion meets the requirement of oral administration of the compound A.

Abstract: Apparatus and methods relating to photonic bandgap optical nanostructures are described. Such optical nanostructures may exhibit prohibited photonic bandgaps or allowed photonic bands, and may be used to reject (e.g., block or attenuate) radiation at a first wavelength while allowing transmission of radiation at a second wavelength. Examples of photonic bandgap optical nanostructures includes periodic and quasi-periodic structures, with periodicity or quasi-periodicity in one, two, or three dimensions and structural variations in at least two dimensions. Such photonic bandgap optical nanostructures may be formed in integrated devices that include photodiodes and CMOS circuitry arranged to analyze radiation received by the photodiodes.

Abstract: Systems and methods for optical power distribution within an integrated device, in a substantially uniform manner, to a large number of sample wells and/or other photonic elements. The integrated device and related instruments and systems may be used to analyze samples in parallel. The integrated device may include a grating coupler configured to receive light from an excitation source and optically couple with multiple waveguides configured to couple with sample wells. Vertical extents of optical modes of individual waveguides may be modulated to adjust confinement of light within the waveguides. This modulation may enable more uniform distribution of excitation light to the sample wells, improve excitation efficiency, and prevent overpower on regions of the integrated device.

Abstract: A light transmissive substrate for transforming a Lambertian light distribution into a batwing light distribution. The light transmissive substrate includes a first surface comprising a plurality of microstructures, and a second surface on a side of the substrate opposite the first surface. The substrate is configured to receive light in a Lambertian distribution from a light source at the first surface and transform the light into a batwing distribution exiting the second surface. The batwing distribution having a peak intensity at about ±30° to about ±60° from X and Y axes, and a minimum intensity at nadir.

Abstract: A photonics grating coupler to transmit light in a light detection and ranging (LiDAR) system includes a receiver component adapted to receive light transmitted from an optical source. The photonics grating coupler includes a plurality of light scattering elements arranged in a rectangular pattern, wherein the plurality of light scattering elements comprises a first set of light scattering elements, each light scattering element comprising a first cross section and a first duty cycle and adapted to receive the light from the receiver to produce reflected light. The photonics grating coupler also includes a second set of light scattering elements, each light scattering element comprising a second cross section and a second duty cycle and adapted to transmit the reflected light towards a waveguide coupled to receive the reflected light.

Abstract: A frequency-modulated continuous-wave (FMCW) light detection and ranging (LiDAR) system includes an optical source to direct optical beams towards a target object, and a plurality of return signals are returned to the LiDAR system. The LiDAR system includes a reflective optical component to return a portion of the plurality of optical beams along a return path as a local oscillator (LO) signal, a rotating scanning mirror between the optical source and the target object, and a plurality of optical detectors. The plurality of optical detectors receives and consumes the plurality of return signals. The LiDAR system also includes an optical circuit implemented on a photonics chip that include a plurality of photonics couplers. The plurality of photonics couplers produces a plurality of outputs that are combined by the optical circuit. A signal processing system consumes the outputs.

Abstract: An edge-lit back light unit includes a specular reflector and an edge-lit light guide film positioned above the specular reflector, both configured to provide peak optical distribution and FWHM angle of diffusion along a light propagation direction. A diffuser film above the edge-lit light guide film has a bottom-side that faces the edge-lit light guide film and a top-side that faces away from the edge-lit light guide film, and has a plurality of parallel prism microstructures on the bottom-side, some have an apex direction that is generally along the light propagation direction. The diffuser film has a plurality of parallel prism microstructures on the top-side having an apex direction that is rotated with respect to the apex direction of the plurality of parallel prism microstructures on the bottom-side such that the apex direction of the parallel prism microstructures on the top-side is generally perpendicular to the light propagation direction.

Abstract: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.

Abstract: An optical structure is described for correcting display viewing angle color shift. The optical structure includes a microlens array layer having a first surface and a second surface forming an array of microlenses. A portion of the microlens array layer is formed of a color loading material having a density that results in a desired difference between a color shift at a non-zero viewing angle and a color shift at a zero viewing angle.

Abstract: A polarization splitter-rotator (PSR) is described. The PSR having a silicon nitride based waveguide including a first silicon nitride segment comprising a tapered width in a longitudinal direction and a ridge extending in a transverse direction and an adiabatic coupler coupled with the first silicon nitride segment.

Abstract: An edge-lit back light unit for a backlit display includes a reflector, an edge-lit light guide film, a diffuser film, and a pair of crossed brightness enhancement films with increased efficiency. The diffuser film has an angular light distribution output that is matched to light acceptance angles of the pair of crossed brightness enhancement films to provide increased on-axis brightness without having to increase power to the edge-lit back light unit.

Abstract: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.

Abstract: Apparatus and methods relating to photonic bandgap optical nanostructures are described. Such optical nanostructures may exhibit prohibited photonic bandgaps or allowed photonic bands, and may be used to reject (e.g., block or attenuate) radiation at a first wavelength while allowing transmission of radiation at a second wavelength. Examples of photonic bandgap optical nanostructures includes periodic and quasi-periodic structures, with periodicity or quasi-periodicity in one, two, or three dimensions and structural variations in at least two dimensions. Such photonic bandgap optical nanostructures may be formed in integrated devices that include photodiodes and CMOS circuitry arranged to analyze radiation received by the photodiodes.

Abstract: A polarization splitter-rotator (PSR) is described. The PSR having a silicon nitride based waveguide to split and rotate an optical beam. The silicon nitride based waveguide having a first silicon nitride segment including a first layer and a second layer coupled with the first layer.

Abstract: An optical film for a back light unit that includes an array of light emitting diodes. The optical film includes a substrate, and a plurality of regions of spatially modulated microstructures on at least one side of the substrate. The spatially modulated microstructures have different sizes and/or shapes configured to create a gradient structure within each region. The gradient structure within each region is constructed and arranged to cause more spreading of light when positioned directly above an individual light emitting diode and less spreading of light at locations not directly above an individual light emitting diode. Within the back light unit, the gradient structure converts light beams emitted by the respective light emitting diode at different angles into a more uniform and higher on-axis luminance upon exiting the back light unit.

Abstract: A clothing aroma-enhancing bead composition and a method for preparing same are provided. The clothing aroma-enhancing bead composition includes the following raw materials in percentage by weight: 60-95% of sugar granules, 1.0-20% of liquid essence, and 0.5-20% of silica. The clothing aroma-enhancing bead composition takes the sugar granules as a core, and surfaces of the sugar granules are coated with the liquid essence and the silica. The clothing aroma-enhancing bead composition is attractive in appearance, good in solubility, and simple in production process.

Abstract: A light transmissive structure includes a light transmissive substrate having first and second opposing faces, and an array of microprism elements on the first face. Each microprism element includes a first inclined surface disposed at a first inclined angle relative to the second face, and a second inclined surface disposed at a second inclined angle relative to the second face. The first inclined angle is less than the second inclined angle, and a peak angle between the first inclined surface and second inclined surface is in the range of about 70 degrees to about 100 degrees. The second inclined surface has a convex curvature when viewed from angles perpendicular thereto. The light transmissive structure is configured to receive light from a light source facing the first face in a first direction and redistribute light emerging from the second face in a second direction different from the first direction.

Abstract: A back light unit includes an array of LEDs positioned in rows and columns that emit light from a top surface. A light splitting optical film includes a plurality of inverted pyramids positioned on a first side facing the top surface of the array where each of the plurality of inverted pyramids forms an apex oriented in a direction away from the top surface of the array. A plurality of linear prisms is positioned in a parallel configuration on a second side facing away from the top surface of the array where at least some of the linear prisms form an apex being oriented such that a direction of the apex forms a desired angle with respect to a direction of a row of the array of light emitting diodes.

Abstract: Optical waveguides and couplers for delivering light to an array of photonic elements in a photonic integrated device. The photonic integrated device and related instruments and systems may be used to analyze samples in parallel. The photonic integrated device may include a grating coupler configured to receive light from an external light source and optically couple with multiple waveguides configured to optically couple with sample wells of the photonic integrated device.

Abstract: Optical waveguides and couplers for delivering light to an array of photonic elements in a photonic integrated device. The photonic integrated device and related instruments and systems may be used to analyze samples in parallel. The photonic integrated device may include a grating coupler configured to receive light from an external light source and optically couple with multiple waveguides configured to optically couple with sample wells of the photonic integrated device.