Patents by Inventor Bing-Shiou Yang

Bing-Shiou Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140249174
    Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
    Type: Application
    Filed: February 26, 2014
    Publication date: September 4, 2014
    Inventors: Matthias Eckhardt, Hans-Juergen Martin, Martin Schuehle, Sandra Sick, Bing Shiou Yang
  • Publication number: 20140094486
    Abstract: The invention relates to novel crystalline forms of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, the hydrochloride salt thereof, novel crystalline forms of the hydrochloride salt, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the treatment of Human Immunodeficiency Virus (HIV) infection.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 3, 2014
    Inventors: Zheng Jane LI, Zhibin LI, Laibin LUO, Thomas OFFERDAHL, Soojin KIM, Bing-Shiou YANG
  • Patent number: 8609670
    Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: December 17, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pascale A. J. Pouzet, Peter Nickolaus, Ulrike Werthmann, Rogelio Perez Frutos, Bing-Shiou Yang, Soojin Kim, Jason Alan Mulder, Nitinchandra D. Patel, Chris Hugh Sananayake, Thomas Gabriel Tampone, Xudong Wei
  • Publication number: 20130317061
    Abstract: This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Application
    Filed: July 30, 2013
    Publication date: November 28, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Bing-Shiou YANG, Ka YIP
  • Publication number: 20130261134
    Abstract: This invention relates to novel mesylate salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in methods for the treatment of Hepatitis C Viral (HCV) infection:
    Type: Application
    Filed: March 15, 2013
    Publication date: October 3, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Zhibin LI, Bing-Shiou YANG, Kazuhiko YIP
  • Patent number: 8530497
    Abstract: This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: September 10, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bing-Shiou Yang, Ka Yip
  • Publication number: 20130079359
    Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: August 23, 2012
    Publication date: March 28, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Pascale A.J. POUZET, Peter NICKOLAUS, Ulrike WERTHMANN, Rogelio Perez FRUTOS, Bing-Shiou YANG, Soojin KIM, Jason Alan MULDER, Nitinchandra D. PATEL, Chris Hugh SENANAYAKE, Thomas Gabriel TAMPONE, Xudong WEI
  • Publication number: 20130059866
    Abstract: The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
    Type: Application
    Filed: February 23, 2012
    Publication date: March 7, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Horst Dollinger, Rogelio Perez Frutos, Soojin Kim, Jason Alan Mulder, Peter Nickolaus, Nitinchandra D. Patel, Pascale Pouzet, Chris Hugh Senanayake, Thomas Gabriel Tampone, Xudong Wei, Ulrike Werthmann, Bing-Shiou Yang
  • Publication number: 20120302584
    Abstract: Provided are crystalline N-methyl-glucamine and sodium salts of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl] acetic acid, processes for their preparation, pharmaceutical compositions comprising the salts, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a CRTH2-mediated disorder or disease.
    Type: Application
    Filed: November 17, 2010
    Publication date: November 29, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventor: Bing-Shiou Yang
  • Publication number: 20120157488
    Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 21, 2012
    Applicant: Boehringer-Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Hans-Juergen Martin, Martin Schuehle, Sandra Sick, Bing-Shiou Yang
  • Publication number: 20120059033
    Abstract: This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Application
    Filed: March 9, 2011
    Publication date: March 8, 2012
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Bing-Shiou YANG, Ka YIP
  • Publication number: 20110294828
    Abstract: Provided is a process for preparing a choline salt of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl]acetic acid. The process of the invention is useful for preparing the salt in purer forms of the salt. Also disclosed is a more pure form of the of choline salt of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl]acetic acid.
    Type: Application
    Filed: November 19, 2010
    Publication date: December 1, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Dhileepkumar Krishnamurthy, Juan Manuel Rodriguez Dehli, Michael Schul, Xiao-Jun Wang, Bing-Shiou Yang
  • Patent number: 7851476
    Abstract: Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine its salts and solvates thereof are herein set forth, as are pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: December 14, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chung-Pin H. Chen, Dawn DiGiugno Parker, Qi Gao, Chong-Hui Gu, Jaquan Kalani Levons, Bing-Shiou Yang
  • Publication number: 20080188517
    Abstract: The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof, processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.
    Type: Application
    Filed: April 9, 2008
    Publication date: August 7, 2008
    Applicant: Bristol-Myers Squibb Company
    Inventors: Michael J. Orwat, Mary F. Malley, Roxana Schlam, Steven R. Fabian, Bing-Shiou Yang, Victor W. Rosso
  • Patent number: 7371864
    Abstract: The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: May 13, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael J. Orwat, Mary F. Malley, Roxana Schlam, Steven R. Fabian, Bing-Shiou Yang, Victor W. Rosso
  • Publication number: 20070155702
    Abstract: The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
    Type: Application
    Filed: December 11, 2006
    Publication date: July 5, 2007
    Inventors: Chung-Pin Chen, Dawn Parker, Qi Gao, Chong-Hui Gu, Jaquan Levons, Bing-Shiou Yang
  • Publication number: 20060160841
    Abstract: The invention relates to a process or apparatus for transforming a first polymorph of a chemical material into a second polymorph of the same chemical material, utilizing an apparatus comprising a vessel connected to a re-circulation system, the process comprising the steps of: suspending said first polymorph in a solution to form a slurry in the vessel, re-circulating the slurry and removing the slurry from the vessel.
    Type: Application
    Filed: September 26, 2005
    Publication date: July 20, 2006
    Inventors: Chenkou Wei, Bing-Shiou Yang
  • Publication number: 20060148846
    Abstract: The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.
    Type: Application
    Filed: December 14, 2005
    Publication date: July 6, 2006
    Inventors: Michael Orwat, Mary Malley, Roxana Schlam, Steven Fabian, Bing-Shiou Yang, Victor Rosso