Abstract: The present application provides methods for promoting persistent of a cell therapy by using a combination regimen including both a lymphodepleting agent (such as fludarabine and/or cyclophosphamide) and an S-phase inhibitor (e.g., methotrexate) in an individual who receives the cell therapy such as allogeneic CAR-T cell therapy. Pharmaceutical compositions and kits comprising the lymphodepleting agent, S-phase inhibitor and/or the immune cells used in the cell therapy are also provided.

Abstract: This application provides a MEMS microphone, a preparation method therefor. The MEMS microphone includes a circuit board, a MEMS chip, and an ASIC chip, where the circuit board is provided with a sound hole, the sound hole runs through the circuit board in a thickness direction of the circuit board, the MEMS chip is mounted on the circuit board, covers the sound hole, and is electrically connected to the circuit board, a sound cavity of the MEMS chip is in communication with the sound hole, and the ASIC chip is mounted on a side surface of the MEMS chip and is electrically connected to both the MEMS chip and the circuit board.

Abstract: The dual basic input/output system (BIOS) system includes: a first BIOS chip, configured to run a first BIOS sub-system; a second BIOS chip, configured to run a second BIOS sub-system; a baseboard management controller (BMC) chip, configured to run a BMC program; a BMC control chip, configured to control the BMC chip and the second BIOS chip, the BMC control chip being connected to the BMC chip and the second BIOS chip; and a platform controller hub, configured to control the first BIOS chip and the BMC control chip, the platform controller hub being connected to the first BIOS chip via a first bus and connected to the BMC control chip via a second bus, the first bus being connected to the second bus, and the platform controller hub being connected to a central processing unit (CPU).

Abstract: Provided are a display panel and a display device. The display panel includes a substrate and a drive circuit disposed on one side of the substrate. The drive circuit includes a first transistor. The first transistor includes a first active layer. The first active layer includes an oxide semiconductor. The drive circuit also includes a first capacitor. One capacitor plate of the first capacitor is disposed in the same layer as the first active layer. In the display panel according to embodiments of the present disclosure, a substrate of a first capacitor in a drive circuit is disposed in the same layer as an active layer of an oxide semiconductor.

Abstract: A high-voltage loop control system is provided, including a detection apparatus and a vehicle. The detection apparatus includes: a detection circuit, where the detection circuit is configured to connect to a charging port of the vehicle to form a detection loop, and the detection loop is adapted to trigger disconnection of a high-voltage loop of the vehicle.

Abstract: A reinforced concrete dynamic protection system with both damage self-sensing and active corrosion protection is provided, including a rebar skeleton, conductive self-sensing concrete, a stainless steel electrode, a solar power supply, and a monitoring control system. The rebar skeleton is connected to a negative electrode of the solar power supply, and the conductive self-sensing concrete is poured around the rebar skeleton as a conductive path and crack monitoring; the stainless steel electrode is buried on a surface layer of the self-sensing concrete and is connected to an anode of the solar power supply to form a cathodic protection system loop; and the monitoring control system is configured to analyze an electrical signal in the system loop and control a frequency and voltage of a pulsed current.

Abstract: Example embodiments are directed to a system that facilitates machine learning model inference simulation. A model inference simulation request is received. A model specification is identified based on the model inference simulation request. A job workflow is generated based on the model specification and the model inference simulation request. A model inference simulation result is generated using a machine learning model associated with the model specification. The model inference simulation result is then caused to be displayed on a user interface.

Abstract: This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3?-Siallylactose (3?-SL) and 6?-Siallylactose (6?-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

Abstract: Some aspects relate to technologies for leveraging metadata to automatically detect fraudulent trends in online transactions and to generate risk rules based on the fraudulent trends. In accordance with some aspects, event data related to online transactions on an online transaction platform is collected. The event data is collected and enriched using a first set of metadata from a metadata store to provide enriched data. A fraudulent trend is detected by analyzing the enriched data using one or more clustering and/or predictive algorithms guided by a second set of metadata from the metadata store. A risk rule is then generated based on the fraudulent trend using a third set of metadata from the metadata store. The risk rule is deployed to an online fraud detection system to identify fraudulent transactions on the online transaction platform.

Abstract: A method for recording data and an apparatus, an electronic device and a non-transitory computer readable storage medium is provided, and relates to the field of computer technologies. The method includes: configuring a BIOS and a BMC to share a shared memory of a CPU respectively, wherein the shared memory is a preset area of a memory mounted by the CPU; establishing a rule for using the shared memory for the BIOS and the BMC; when a server is started, checking a shared channel for the shared memory to determine whether the shared memory is successfully initialized; and transferring data related to RAS collected by the BIOS to the BMC via the shared memory based on the rule for using the shared memory, in a case where the shared memory is successfully initialized.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof that are useful in the treatment of alpha-1 antitrypsin deficiency. Also provided herein are pharmaceutical compositions and kits comprising compounds of Formula (I), as well as methods of treating alpha-1 antitrypsin deficiency.

Abstract: The present disclosure relates to novel compounds, and tautomers, stereoisomers or pharmaceutically acceptable salts thereof, which modulate the level or activity of Nrf2 protein. The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds and tautomers, stereoisomers, or pharmaceutically acceptable salts thereof as an active ingredient, and to the use of the compounds and tautomers, stereoisomers, or pharmaceutically acceptable salts thereof in the treatment of Nrf2-associated diseases, disorders or conditions, including ocular diseases or kidney diseases.

Abstract: A secondary cell adding method, a terminal, and a chip are disclosed, which relate to the field of communication technologies. The method is performed by a terminal and includes: camping on a first primary cell supporting NSA; receiving, a secondary cell measurement message from a network device, where the secondary cell measurement message includes a frequency of a first secondary cell and a first signal energy threshold, and a frequency of a second secondary cell and a second signal energy threshold; performing secondary cell measurement based on the frequency of the first secondary cell, where a priority of the frequency of the first secondary cell is higher than a priority of the frequency of the second secondary cell; and performing an operation of adding the first secondary cell if signal energy detected at the frequency of the first secondary cell is greater than the first signal energy threshold.

Abstract: The disclosure relates to a construction method and device for a chemical knowledge graph, an intelligent question answering method and device for chemical knowledge, and two computer-readable storage media. The construction method comprises the following steps: obtaining knowledge data in chemical industry field; pre-processing the knowledge data to obtain entity data and property data related to chemical knowledge; determining a preliminary knowledge representation according to the entity data and the property data; performing entity alignment on the preliminary knowledge representation to obtain a standard knowledge representation; and constructing the chemical knowledge graph according to the standard knowledge representation.

Abstract: Provided are a display panel and a display apparatus. The display panel includes a plurality of pixel circuits and a plurality of light-emitting devices, and the light-emitting devices are connected to the pixel circuits. Each of the pixel circuits includes a driving transistor, a data writing transistor, a threshold compensation transistor, and a gate reset transistor. An active layer of the driving transistor contains silicon. The gate reset transistor is electrically connected to a second electrode of the driving transistor, and an active layer of the gate reset transistor contains metal oxide. Alternatively, an active layer of an electrode reset transistor contains metal oxide. The present disclosure can raise a voltage of a low-level signal required for controlling a transistor, such that a difference between a high-level signal and the low-level signal required for controlling the transistor decreases, thereby reducing power consumption.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to a process for the production of a carbonate polyester (co)polymer which includes the use of bis(2-methoxyphenyl) carbonate to introduce carbonate monomer units into the polymer chain. The process is an efficient process for the production of novel and existing carbonate polyester (co)polymers, also with high molecular weight, and optionally without the need for the addition of a metal catalyst.