Abstract: The present disclosure relates to novel compounds, and tautomers, stereoisomers or pharmaceutically acceptable salts thereof, which modulate the level or activity of Nrf2 protein. The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds and tautomers, stereoisomers, or pharmaceutically acceptable salts thereof as an active ingredient, and to the use of the compounds and tautomers, stereoisomers, or pharmaceutically acceptable salts thereof in the treatment of Nrf2-associated diseases, disorders or conditions, including ocular diseases or kidney diseases.

Abstract: A secondary cell adding method, a terminal, and a chip are disclosed, which relate to the field of communication technologies. The method is performed by a terminal and includes: camping on a first primary cell supporting NSA; receiving, a secondary cell measurement message from a network device, where the secondary cell measurement message includes a frequency of a first secondary cell and a first signal energy threshold, and a frequency of a second secondary cell and a second signal energy threshold; performing secondary cell measurement based on the frequency of the first secondary cell, where a priority of the frequency of the first secondary cell is higher than a priority of the frequency of the second secondary cell; and performing an operation of adding the first secondary cell if signal energy detected at the frequency of the first secondary cell is greater than the first signal energy threshold.

Abstract: The disclosure relates to a construction method and device for a chemical knowledge graph, an intelligent question answering method and device for chemical knowledge, and two computer-readable storage media. The construction method comprises the following steps: obtaining knowledge data in chemical industry field; pre-processing the knowledge data to obtain entity data and property data related to chemical knowledge; determining a preliminary knowledge representation according to the entity data and the property data; performing entity alignment on the preliminary knowledge representation to obtain a standard knowledge representation; and constructing the chemical knowledge graph according to the standard knowledge representation.

Abstract: Provided are a display panel and a display apparatus. The display panel includes a plurality of pixel circuits and a plurality of light-emitting devices, and the light-emitting devices are connected to the pixel circuits. Each of the pixel circuits includes a driving transistor, a data writing transistor, a threshold compensation transistor, and a gate reset transistor. An active layer of the driving transistor contains silicon. The gate reset transistor is electrically connected to a second electrode of the driving transistor, and an active layer of the gate reset transistor contains metal oxide. Alternatively, an active layer of an electrode reset transistor contains metal oxide. The present disclosure can raise a voltage of a low-level signal required for controlling a transistor, such that a difference between a high-level signal and the low-level signal required for controlling the transistor decreases, thereby reducing power consumption.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to a process for the production of a carbonate polyester (co)polymer which includes the use of bis(2-methoxyphenyl) carbonate to introduce carbonate monomer units into the polymer chain. The process is an efficient process for the production of novel and existing carbonate polyester (co)polymers, also with high molecular weight, and optionally without the need for the addition of a metal catalyst.

Abstract: The invention relates to a process for the production of a (high molecular weight) polyester (co)polymer. The process includes (a) adding a diphenyl oxalate ester to a starting polyester (co)polymer at least comprising alcohol end groups and units derived from 1,2-diols, wherein the phenyl group in the diphenyl oxalate ester is substituted; and (b) in case the temperature is not already higher than 220° C., elevating the temperature of the mixture resulting from step (a) to at least 220° C., and reducing the pressure, for a period of time sufficient to obtain a polyester (co)polymer product wherein the amount of oxalate units that remain in the (co)polymer is less than added in the form of the diphenyl oxalate ester; and no or less than 1 mole % oxalate units are present, the percentage relative to a total amount of monomer units.

Abstract: The invention relates to a process for the production of a (high molecular weight) polyester (co)polymer. The process includes (a) adding a diphenyl oxalate ester to a starting polyester (co)polymer at least comprising alcohol end groups and units derived from 1,2-diols, wherein the phenyl group in the diphenyl oxalate ester is optionally substituted; and (b) in case the temperature is not already higher than 220° C., elevating the temperature of the mixture resulting from step (a) to at least 220° C., and reducing the pressure, for a period of time sufficient to obtain a polyester (co)polymer product wherein the amount of oxalate units that remain in the (co)polymer is less than added in the form of the diphenyl oxalate ester; and no or less than 1 mole % oxalate units are present, the percentage relative to a total amount of monomer units.

Abstract: The invention relates to a process for the production of a polyester (co)polymer, comprising the use of a diguaiacyl dicarboxylate ester as a chain extender, wherein the dicarboxylate is derived from a dicarboxylic acid selected from (hetero)aromatic dicarboxylic acids, and from C3-C18 aliphatic dicarboxylic acids which may be linear, cyclic or branched. The process is an efficient process for the production of novel and existing polyester (co)polymers with high molecular weight, and optionally without the need for the addition of a metal catalyst.

Abstract: A vehicle body structure and a vehicle are disclosed. The vehicle body structure includes longitudinal beams, a cross beam, a trunk, an air tank, an air pump, and a rear suspension. The longitudinal beams and the cross beam are connected with each other, and the longitudinal beams and the cross beam are arranged to support other structural components of the vehicle body structure. The longitudinal beams extend into the trunk. The air pump is connected with one of the longitudinal beams extending into the trunk. The air pump and the air tank are at both sides of a central axis of the vehicle body structure respectively, and are located close to the rear suspension.

Abstract: Provided is a wiring substrate. The wiring substrate includes a base substrate, a plurality of signal lines, a first protective layer, and a plurality of additional conductive portions. The base substrate includes a first region and a fan-out region. Each of the signal lines includes a first portion disposed in the first region and a second portion disposed in the fan-out region. The first protective layer includes a plurality of openings including at least one of a first opening disposed in the fan-out region and a second opening disposed in the first region. The plurality of additional conductive portions include at least one of a first additional conductive portion and a second additional conductive portion. The first additional conductive portion is electrically coupled to the signal line at the first opening, and the second additional conductive portion is electrically coupled to the signal line at the second opening.

Abstract: The invention relates to a process for the production of an oxalate polyester (co)polymer, comprising the use of bis(2-methoxyphenyl) oxalate to introduce oxalate monomer units into the polymer chain, comprising at least steps (a) and (b): (a) an esterification/transesterification step wherein at least one dicarboxylic acid or an ester derivative thereof is/are reacted with an excess of at least one diol compound to form a pre-polycondensation product comprising alcohol end groups, or otherwise producing such pre-polycondensation product; (b) a polymerization step comprising polycondensation of the product of step (a) with bis(2-methoxyphenyl) oxalate in a molar amount that is equal to between about 0.4 to about 0.6 equivalents of the molar amount of alcohol end groups in the pre-polycondensation product of step (a).

Abstract: A closed heat-not-burn cigarette and an assembly. The assembly comprises a closed heat-not-burn cigarette (1) and a heating smoking set (2), wherein when in use, the closed heat-not-burn cigarette (1) is inserted into the heating smoking set (2) where the cigarette is heated for smoking.

Abstract: In one embodiment, the invention provides a dual-cassette gene vehicle comprising cassettes for expression of both a mini-dystrophin gene and NF-?B/p65-shRNA gene in cardiac muscle tissue and skeletal muscle tissue, which is an adeno-associated viral (AAV) vector, wherein the mini-dystrophin gene is operably linked to a construct comprising a muscle-specific first promoter and a modified Mcken (MCK) enhancer and wherein the NF-?B/p65-shRNA gene is under the control of a second promoter. Also are provided pharmaceutical compositions comprising such gene vehicles and a method for ameliorating Duchenne muscular dystrophy (DMD) employing such gene delivery vehicles and pharmaceutical compositions.

Abstract: Embodiments of the present application relate to the technical field of operating systems, and more particularly, to a dual basic input/output system (BIOS) system, a system switching method and apparatus, a device, and a non-transitory readable storage medium, which aim to improve switching efficiency of the dual BIOS system.

Abstract: A method for recording data and an apparatus, an electronic device and a non-transitory computer readable storage medium is provided, and relates to the field of computer technologies. The method includes: configuring a BIOS and a BMC to share a shared memory of a CPU respectively, wherein the shared memory is a preset area of a memory mounted by the CPU; establishing a rule for using the shared memory for the BIOS and the BMC; when a server is started, checking a shared channel for the shared memory to determine whether the shared memory is successfully initialized; and transferring data related to RAS collected by the BIOS to the BMC via the shared memory based on the rule for using the shared memory, in a case where the shared memory is successfully initialized.

Abstract: This specification relates to the field of mobile communications technologies, and specifically to a network access method and a terminal. The method is applied to a terminal that is connected to the primary access network device and the secondary access network device through the first SIM card, and is connected to the secondary access network device. The method includes: disconnecting, by the terminal, an RRC connection between the terminal and the secondary access network equipment when the terminal executes a first service through the second SIM card; determining, by the terminal, that the first service ends; and actively disconnecting, by the terminal, an RRC connection between the terminal and the primary access network equipment, and sending an RRC connection re-establishment request, so that the terminal is reconnected to the secondary access network equipment through the first SIM card with assistance of the primary access network equipment.

Abstract: A method for preparing a preparing a polymeric positive temperature coefficient (PPTC) compound and conformally applying such compound to a substrate in accordance with an embodiment of the present disclosure may include preparing and mixing raw materials to form a PPTC mixture, processing the PPTC mixture through polymer compounding equipment, wherein the PPTC mixture is heated and is extruded as a PPTC compound, performing a beaming process on the polymer compound to establish crosslinking between polymer chains in the PPTC compound, and applying the PPTC compound to a substrate using a hot application process wherein the PPTC compound is heated and is conformally applied to a surface of the substrate.