Patents by Inventor Bing-Ze Lin

Bing-Ze Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A METHOD FOR CONSTRUCTING A COFILIN-1 TRANSGENIC MODEL AND USE THEREOF
    Publication number: 20240122163
    Abstract: The present invention demonstrated a Cre-loxP based cofilin-1 transgenic animal model to address the pathophysiological role of over-expressed cofilin-1 on systemic development.
    Type: Application
    Filed: February 6, 2023
    Publication date: April 18, 2024
    Inventors: Yi-Jang LEE, Yu-Chuan LIN, Min-Ying LIN, Bing-Ze LIN, Chia-Yun KANG
  • Method for treatment of cellular senescence
    Patent number: 11234993
    Abstract: The present invention provides an alcohol extract of Ajuga taiwanensis Nakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract of A. taiwanensis is able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: February 1, 2022
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Yi-Jang Lee, Yun-Lian Lin, Chung-Sheng Huang, Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yuan-Heng Tu, Wei-Hsiang Hsu, Pin-Ho Lo
  • Method for treatment of cellular senescence
    Publication number: 20200368264
    Abstract: The present invention provides an alcohol extract of Ajuga taiwanensis Nakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract of A. taiwanensis is able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 26, 2020
    Inventors: Yi-Jang Lee, Yun-Lian Lin, Chung-Sheng Huang, Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yuan-Heng Tu, Wei-Hsiang Hsu, Pin-Ho Lo