Patents by Inventor Bingchen YU

Bingchen YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS
    Publication number: 20230105108
    Abstract: Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 6, 2023
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Binghe WANG, David W. BOYKIN, Arvind KUMAR, Mengyuan ZHU, Manjusha ROY CHOUDHURY, Bingchen YU
  • AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS
    Publication number: 20210309641
    Abstract: Compounds and methods for the treatment of a bacterial infection or the potentiation of an antibiotic in treating a bacterial infection are described herein.
    Type: Application
    Filed: June 13, 2019
    Publication date: October 7, 2021
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Binghe Wang, David W. Boykin, Manjusha Roy Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu
  • Hydrogen sulfide precursors and conjugates thereof
    Patent number: 10689335
    Abstract: The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: June 23, 2020
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Binghe Wang, Yueqin Zheng, Kaili Ji, Bingchen Yu, Zhixiang Pan
  • HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF
    Publication number: 20180118674
    Abstract: The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
    Type: Application
    Filed: April 4, 2016
    Publication date: May 3, 2018
    Applicant: Georgia State University Research Foundation, Inc
    Inventors: Binghe Wang, Yueqin ZHENG, Kaili JI, Bingchen YU, Zhixiang PAN