Patents by Inventor Bingcheng Wang

Bingcheng Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide and small molecule agonists of EphA and their uses
    Patent number: 11944624
    Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: April 2, 2024
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bingcheng Wang, Bin Su, Aaron Petty
  • Agonists of EPHA and their uses
    Patent number: 11814372
    Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a small molecule agonist of EphA2 receptor protein, the small molecule having a general formula: A-L-X-Z (I).
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: November 14, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Bingcheng Wang
  • PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES
    Publication number: 20200222405
    Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).
    Type: Application
    Filed: July 3, 2018
    Publication date: July 16, 2020
    Inventors: Bingcheng Wang, Bin Su, Aaron Petty
  • Peptide and small molecule agonists of EPHA and uses thereof
    Patent number: 10434074
    Abstract: Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: October 8, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bingcheng Wang, Eugene Myshkin, Hui Miao
  • AGONISTS OF EPHA AND THEIR USES
    Publication number: 20190002446
    Abstract: A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a small molecule agonist of EphA2 receptor protein, the small molecule having a general formula: A-L-X-Z (I).
    Type: Application
    Filed: July 3, 2018
    Publication date: January 3, 2019
    Inventor: Bingcheng Wang
  • PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND USES THEREOF
    Publication number: 20170157073
    Abstract: Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer.
    Type: Application
    Filed: August 15, 2016
    Publication date: June 8, 2017
    Inventors: Bingcheng Wang, Eugene Myshkin, Hui Miao
  • EphA kinase cancer diagnostic
    Patent number: 8603764
    Abstract: A method of detecting malignant progression of neoplastic cells in an animal includes obtaining a sample of neoplastic cells from the animal, determining a level of S897-EphA2 phosphorylation in the neoplastic cells of the samplem, and comparing the determined level of S897-EphA2 phosphorylation in the sample to a control value, wherein an increased level of S897-EphA2 phosphorylation compared to the control value is indicative of malignant progression of the neoplastic cell in the animal.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: December 10, 2013
    Assignee: Case Western Reserve University
    Inventors: Bingcheng Wang, Hui Miao
  • EphA KINASE CANCER DIAGNOSTIC
    Publication number: 20110027801
    Abstract: A method of detecting malignant progression of neoplastic cells in an animal includes obtaining a sample of neoplastic cells from the animal, determining a level of S897-EphA2 phosphorylation in the neoplastic cells of the samplem, and comparing the determined level of S897-EphA2 phosphorylation in the sample to a control value, wherein an increased level of S897-EphA2 phosphorylation compared to the control value is indicative of malignant progression of the neoplastic cell in the animal.
    Type: Application
    Filed: June 7, 2010
    Publication date: February 3, 2011
    Inventors: BINGCHENG WANG, HUI MIAO
  • PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES IN DISEASE
    Publication number: 20100093626
    Abstract: A method of treating a neoplastic disorder in a subject includes administering to a Eph kinase expressing neoplastic cell of the subject being treated an EphA agonist and at least one immunosuppressant.
    Type: Application
    Filed: December 14, 2007
    Publication date: April 15, 2010
    Inventor: Bingcheng Wang
  • Method for producing a recombinant mammal in vivo
    Patent number: 5215904
    Abstract: A method for producing a recombinant mammal in vivo is disclosed. The mammal has a mammary gland, with mammary epithelial cells lining a duct in that gland One increases the rate of mitosis of the mammary epithelial cells (e.g. by using perphenazine or a mitogen), and one then exposes the mammary epithelial cells in vivo in the gland to a recombinant vector (e.g. a retrovirus vector). The mammary epithelial cells can be pretreated (or simultaneously treated) with polybrene to facilitate infection by virus vectors, and the vector can have a signal sequence which causes foreign proteinaceous material to be secreted into the milk produced by the mammary gland. Also disclosed are recombinant non-human mammals produced by such methods and novel milk products that they produce.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: June 1, 1993
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael N. Gould, Bingcheng Wang