Patents by Inventor Binghe Wang
Binghe Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250011292Abstract: Novel rhodanine derivatives and methods for their use are provided herein. The rhodanine derivatives are useful in treating or preventing viral infections, including coronavirus infections (e.g., a SARS-CoV-2 virus infection). The rhodanine derivatives are also useful as photosensitizers for photodynamic therapy in treating or preventing cancer in a subject.Type: ApplicationFiled: October 12, 2022Publication date: January 9, 2025Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe WANG, Xiaoxiao Yang, Ming Luo, Mukesh Kumar
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Publication number: 20240391886Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.Type: ApplicationFiled: July 11, 2024Publication date: November 28, 2024Applicant: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Xingyue Ji, Ladie Kimberly De La Cruz, Xiaoxiao Yang
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Patent number: 12071415Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.Type: GrantFiled: April 16, 2021Date of Patent: August 27, 2024Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe Wang, Xingyue Ji, Ladie Kimberly de la Cruz, Xiaoxiao Yang
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Patent number: 11685711Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.Type: GrantFiled: August 9, 2018Date of Patent: June 27, 2023Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Ladie Kimberly c. De La Cruz, Xingyue Ji, Zhixiang Pan, Binghe Wang
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Publication number: 20230105108Abstract: Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.Type: ApplicationFiled: December 18, 2020Publication date: April 6, 2023Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe WANG, David W. BOYKIN, Arvind KUMAR, Mengyuan ZHU, Manjusha ROY CHOUDHURY, Bingchen YU
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Patent number: 11607458Abstract: Disclosed herein is a chemical delivery system having: i) a cargo compound comprising a first reactive moiety covalently bonded to a first enrichment moiety and a tethered cargo moiety, wherein the first reactive moiety is bonded to the tethered cargo moiety via a cleavable linker; and ii) a trigger compound comprising a second reactive moiety covalently bonded to a second enrichment moiety and a cargo-releasing moiety. The first enrichment moiety and the second enrichment moiety cause an increase in concentration of the cargo compound and the concentration of the trigger compound at a target site, causing a bimolecular reaction between the first reactive moiety and the second reactive moiety to form a cyclization precursor compound. The cargo moiety is then released from the cyclization precursor compound in a unimolecular cyclization reaction. Methods for treating conditions such as cancer, inflammatory conditions, and infections with the chemical delivery systems are also described.Type: GrantFiled: October 25, 2018Date of Patent: March 21, 2023Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe Wang, Yueqin Zheng, Xingyue Ji, Robert Emuobonuvie Aghoghovbia
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Patent number: 11420994Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: GrantFiled: November 15, 2017Date of Patent: August 23, 2022Assignee: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Xingyue Ji, Zhixiang Pan
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Patent number: 11377435Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs. The compounds disclosed herein contain a cyclopentadienone moiety, a non-reactive dienophile, and an enzyme-cleavable tethering moiety connecting the cyclopentadienone moiety to the non-reactive dienophile. Cleavage of the enzyme-cleavable tethering moiety results in conversion of the non-reactive dienophile to a reactive dienophile.Type: GrantFiled: December 12, 2019Date of Patent: July 5, 2022Assignee: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Xingyue Ji
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Publication number: 20210309641Abstract: Compounds and methods for the treatment of a bacterial infection or the potentiation of an antibiotic in treating a bacterial infection are described herein.Type: ApplicationFiled: June 13, 2019Publication date: October 7, 2021Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe Wang, David W. Boykin, Manjusha Roy Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu
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Publication number: 20210238155Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.Type: ApplicationFiled: April 16, 2021Publication date: August 5, 2021Applicant: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Xingyue Ji, Ladie Kim De La Cruz, Xiaoxiao Yang
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Publication number: 20210221835Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: ApplicationFiled: November 15, 2017Publication date: July 22, 2021Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe WANG, Xingyue Jl, Zhixiang PAN
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Publication number: 20210000965Abstract: Disclosed herein is a chemical delivery system having: i) a cargo compound comprising a first reactive moiety covalently bonded to a first enrichment moiety and a tethered cargo moiety, wherein the first reactive moiety is bonded to the tethered cargo moiety via a cleavable linker; and ii) a trigger compound comprising a second reactive moiety covalently bonded to a second enrichment moiety and a cargo-releasing moiety. The first enrichment moiety and the second enrichment moiety cause an increase in concentration of the cargo compound and the concentration of the trigger compound at a target site, causing a bimolecular reaction between the first reactive moiety and the second reactive moiety to form a cyclization precursor compound. The cargo moiety is then released from the cyclization precursor compound in a unimolecular cyclization reaction. Methods for treating conditions such as cancer, inflammatory conditions, and infections with the chemical delivery systems are also described.Type: ApplicationFiled: October 25, 2018Publication date: January 7, 2021Applicant: Georgia State University Research Foundation, IncInventors: Binghe Wang, Yueqin Zheng, Xingyue Ji, Robert Emuobonuvie Aghoghovbia
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Patent number: 10772858Abstract: This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiment, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof.Type: GrantFiled: May 2, 2016Date of Patent: September 15, 2020Assignees: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., EMORY UNIVERSITYInventors: Binghe Wang, Erwin Van Meir, Jalisa Holmes Ferguson, Stefan Kaluz, Xingyue Ji
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Publication number: 20200283382Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.Type: ApplicationFiled: August 9, 2018Publication date: September 10, 2020Applicant: Georgia State University Research Foundation, Inc.Inventors: Ladie Kimberly c. De La Cruz, Xingyue Ji, Zhixiang Pan, Binghe Wang
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Patent number: 10751344Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: GrantFiled: May 27, 2019Date of Patent: August 25, 2020Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Binghe Wang, Danzhu Wang, Xingyue Ji, Alexander Draganov, Chaofeng Dai, Krishna Damera, Didier Merlin, Emilie Viennois, Yueqin Zheng
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Patent number: 10689335Abstract: The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.Type: GrantFiled: April 4, 2016Date of Patent: June 23, 2020Assignee: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Yueqin Zheng, Kaili Ji, Bingchen Yu, Zhixiang Pan
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Publication number: 20200115360Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs. The compounds disclosed herein contain a cyclopentadienone moiety, a non-reactive dienophile, and an enzyme-cleavable tethering moiety connecting the cyclopentadienone moiety to the non-reactive dienophile.Type: ApplicationFiled: December 12, 2019Publication date: April 16, 2020Inventors: Binghe Wang, Xingyue Ji
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Patent number: 10544090Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.Type: GrantFiled: July 10, 2013Date of Patent: January 28, 2020Assignees: Georgia State University Research Foundation, Inc., Emory University, Children's Healthcare of Atlanta, Inc.Inventors: Binghe Wang, Chaofeng Dai, Alexander Draganov, Xiaochuan Yang, Guojing Sun, Chunhao Yang, Weixuan Chen, Nanting Ni, Muxiang Zhou, Lubing Gu
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Publication number: 20190350937Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: ApplicationFiled: May 27, 2019Publication date: November 21, 2019Inventors: Binghe Wang, Danzhu Wang, Xingyue Ji, Alexander Draganov, Chaofeng Dai, Krishna Damera, Didier Merlin, Emilie Viennois, Yueqin Zheng
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Patent number: 10300069Abstract: Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37 C and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.Type: GrantFiled: June 9, 2015Date of Patent: May 28, 2019Assignee: Georgia State University Research Foundation, Inc.Inventors: Binghe Wang, Danzhu Wang, Xingyue Ji, Alexander Draganov, Chaofeng Dai, Krishna Damera, Didier Merlin, Emilie Viennois, Yueqin Zheng