Patents by Inventor Binglan Yu

Binglan Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180221619
    Abstract: In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.
    Type: Application
    Filed: January 25, 2018
    Publication date: August 9, 2018
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Patent number: 9572833
    Abstract: Compositions and methods for treating red blood cells are disclosed. The methods include contacting a red blood cell sample ex vivo with an amount of nitric oxide or a nitric oxide-releasing compound sufficient to convert at least a portion of the extracellular ferrous hemoglobin present in the red blood cell sample to ferric hemoglobin. Red blood cells administered to a mammal following the ex vivo treatment have reduced adverse effects on the mammal to which they are administered.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: February 21, 2017
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu
  • Publication number: 20160038710
    Abstract: A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: WARREN M. ZAPOL, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Publication number: 20160030699
    Abstract: In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Patent number: 8887721
    Abstract: Compositions and methods for preventing or reducing vasoconstriction in a mammal following administration of an artificial oxygen carrier (e.g., a hemoglobin-based oxygen carrier) are disclosed. The methods include administering to a mammal a composition containing an artificial oxygen carrier in combination with one or more of a nitric oxide-releasing compound, a therapeutic gas containing gaseous nitric oxide, a phosphodiesterase inhibitor, and/or a soluble guanylate cyclase sensitizer.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: November 18, 2014
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Fumito Ichinose
  • Publication number: 20140286921
    Abstract: Compositions and methods for treating red blood cells are disclosed. The methods include contacting a red blood cell sample ex vivo with an amount of nitric oxide or a nitric oxide-releasing compound sufficient to convert at least a portion of the extracellular ferrous hemoglobin present in the red blood cell sample to ferric hemoglobin. Red blood cells administered to a mammal following the ex vivo treatment have reduced adverse effects on the mammal to which they are administered.
    Type: Application
    Filed: November 6, 2012
    Publication date: September 25, 2014
    Inventors: Warren M. Zapol, Binglan Yu
  • Publication number: 20100051025
    Abstract: Compositions and methods for preventing or reducing vasoconstriction in a mammal following administration of an artificial oxygen carrier (e.g., a hemoglobin-based oxygen carrier) are disclosed. The methods include administering to a mammal a composition containing an artificial oxygen carrier in combination with one or more of a nitric oxide-releasing compound, a therapeutic gas containing gaseous nitric oxide, a phosphodiesterase inhibitor, and/or a soluble guanylate cyclase sensitizer.
    Type: Application
    Filed: November 6, 2007
    Publication date: March 4, 2010
    Applicant: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Fumito Ichinose
  • Publication number: 20030219491
    Abstract: The present invention relates to a composition for inhibiting tumor growth, which comprises a tumor growth inhibiting enzymatic moiety in association with at least one protective carrier. The present invention further relates to the methods of inhibiting tumor growth using this composition.
    Type: Application
    Filed: March 18, 2003
    Publication date: November 27, 2003
    Inventors: Thomas Chang, Binglan Yu