Abstract: Disclosed is an inter- and intra-catheter flow device for the management of vascular bleeding disorders that provide a liquid flow-pass between proximal and distal balloons for bridging the circulation between the upper and lower segments of a hemorrhaging artery or blood vessel, while blocking the blood flow to the hemorrhaging middle segment(s) of the artery or blood vessel between the two or more balloons. When only one balloon is inflated, these devices can create a pressure gradient between proximal or distal and middle segments of the artery or blood vessel. These devices are useful for controlling proximal artery blood pressure, preventing distal ischemia-reperfusion injury, identifying the bleeding location, controlling the bleeding, repairing and remodeling vascular structures, extending resuscitative endovascular balloon occlusion of the aorta (REBOA) use duration, and performing fluid resuscitation.

Abstract: Disclosed is an inter- and intra-catheter flow device for the management of vascular bleeding disorders that provide a liquid flow-pass between proximal and distal balloons for bridging the circulation between the upper and lower segments of a hemorrhaging artery or blood vessel, while blocking the blood flow to the hemorrhaging middle segment(s) of the artery or blood vessel between the two or more balloons. When only one balloon is inflated, these devices can create a pressure gradient between proximal or distal and middle segments of the artery or blood vessel. These devices are useful for controlling proximal artery blood pressure, preventing distal ischemia-reperfusion injury, identifying the bleeding location, controlling the bleeding, repairing and remodeling vascular structures, extending resuscitative endovascular balloon occlusion of the aorta (REBOA) use duration, and performing fluid resuscitation.

Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.

Abstract: Disclosed are devices and methods for body temperature management using a heat exchange device carrying a heat transfer medium to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat exchange device includes a steerable tip that may be manipulated via a steerable control apparatus to route the device through the patient's body to the intended location of treatment. Methods of using such heat exchange device to effect temperature management of the patient's organs are also disclosed.

Abstract: This invention discloses “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, and kits for designing and detecting mutation-specific epitopes/antigens. The ACE methods can detect epitopes that are either absent or poorly recognizable or accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in samples and sample preparations for antibody detection. The ACE methods comprise ACE antigen design and ACE antigen detection. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the ACE methods can artificially and specifically expose hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.

Abstract: This invention discloses “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, and kits for designing and detecting mutation-specific epitopes/antigens. The ACE methods can detect epitopes that are either absent or poorly recognizable or accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in samples and sample preparations for antibody detection. The ACE methods comprise ACE antigen design and ACE antigen detection. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the ACE methods can artificially and specifically expose hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: This invention discloses the “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, immunoaffinity isolation, and kits for all antibody-based applications of designing, detecting, or isolating the common ACE epitopes/antigens in a sample. The ACE methods can detect or isolate epitopes that are either absent or poorly accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in a sample for antibody-based applications. The common ACE structures are those that are the common parts of different macromolecule-to-macromolecule conjugation segments. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications.

Abstract: This invention discloses “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, and kits for designing and detecting hidden epitopes/antigens. The ACE methods can detect epitopes that are either absent or poorly accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in samples and sample preparations for antibody detection. The ACE structures include, but are not limited to, macromolecule-to-macromolecule conjugation sites, and any types of linear hidden epitopes. The ACE methods comprise ACE antigen design and ACE antigen detection. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the ACE methods can artificially and specifically expose hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: This invention discloses the “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, immunoaffinity isolation, and kits for all antibody-based applications of designing, detecting, or isolating the common ACE epitopes/antigens in a sample. The ACE methods can detect or isolate epitopes that are either absent or poorly accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in a sample for antibody-based applications. The common ACE structures are those that are the common parts of different macromolecule-to-macromolecule conjugation segments. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications.

Abstract: This invention discloses methods, antibodies, reagents, immunoassays, and kits of detecting conjugation site-specific and linear hidden epitopes/antigens. The hidden epitopes include, but are not limited to, macromolecule-to-macromolecule conjugation sites, and any type of linear hidden antigens. The methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the methods can detect hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: This invention discloses “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, and kits for designing and detecting hidden epitopes/antigens. The ACE methods can detect epitopes that are either absent or poorly accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in samples and sample preparations for antibody detection. The ACE structures include, but are not limited to, macromolecule-to-macromolecule conjugation sites, and any types of linear hidden epitopes. The ACE methods comprise ACE antigen design and ACE antigen detection. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the ACE methods can artificially and specifically expose hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: The invention relates to polypeptides and proteins known to function in the autophagy pathway that have novel phosphorylation sites. The invention also relates to antibodies specific to these polypeptides and proteins that are phosphorylated or not phosphorylated at novel phosphorylated sites. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.

Abstract: The invention relates to polypeptides and proteins known to function in the autophagy pathway that have novel phosphorylation sites. The invention also relates to antibodies specific to these polypeptides and proteins that are phosphorylated or not phosphorylated at novel phosphorylated sites. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.

Abstract: The invention relates to proteins and peptides of the alpha isoform of light chain 3 (APG8) and antibodies to the APG8 protein, particularly antibodies that specifically bind to the alpha isoform of APG8 when either phosphorylated or not phosphorylated at serine-12 and antibodies that bind to the gamma isoform of APG8 when either phosphorylated or not phosphorylated at serine-9. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.

Abstract: The invention relates to polypeptides and proteins known to function in the autophagy pathway that have novel phosphorylation sites. The invention also relates to antibodies specific to these polypeptides and proteins that are phosphorylated or not phosphorylated at novel phosphorylated sites. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.