Patents by Inventor Bingwei Lu

Bingwei Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11186550
    Abstract: The present invention relates to compositions and methods for the treatment of cancer and other diseases associated with mitochondrial dysfunction, including but not limited to, neurodegenerative disease, brain injuries, and certain non-neurological disorders, using a novel compound CPT-2008 and derivatives thereof.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: November 30, 2021
    Assignee: Cerepeut, Inc.
    Inventor: Bingwei Lu
  • Patent number: 10932722
    Abstract: Disclosed is a flexible and stretchable electronic device based on a biocompatible film. The biocompatible film is utilized as an encapsulation layer and a substrate layer of the device; a bonding layer is provided between the encapsulation layer and a functional layer; and an adhesion layer is arranged under the substrate layer. The functional layer employs a flexible and stretchable structure. Solution-based transfer printing technology is primarily used during the preparation of such a device to achieve integration of the functional layer and the flexible substrate layer. This device retains and even enhances the flexibility and stretchability structurally. Meanwhile, the biocompatibility properties thereof, such as being waterproof and air permeable, hypoallergenic, etc., allow it to work normally on the human body surface for more than 24 hours without foreign body sensation and discomfort, and thus, skin maceration, redness or other allergic reactions due to poor biocompatibility can be avoided.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: March 2, 2021
    Assignee: TSINGHUA UNIVERSITY
    Inventors: Xue Feng, Ying Chen, Honghong Su, Bingwei Lu
  • Publication number: 20200216400
    Abstract: The present invention relates to compositions and methods for the treatment of cancer and other diseases associated with mitochondrial dysfunction, including but not limited to, neurodegenerative disease, brain injuries, and certain non-neurological disorders, using a novel compound CPT-2008 and derivatives thereof.
    Type: Application
    Filed: September 12, 2018
    Publication date: July 9, 2020
    Inventor: Bingwei LU
  • Publication number: 20190105341
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Application
    Filed: December 11, 2018
    Publication date: April 11, 2019
    Inventors: Bingwei Lu, Seongsoo Lee
  • Patent number: 10149860
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: December 11, 2018
    Assignee: Board of Trustees of the Leland Stanford Junior University, Stanford University Office of Technology Licensing
    Inventors: Bingwei Lu, Seongsoo Lee
  • Publication number: 20170340279
    Abstract: Disclosed is a flexible and stretchable electronic device based on a biocompatible film. The biocompatible film is utilized as an encapsulation layer and a substrate layer of the device; a bonding layer is provided between the encapsulation layer and a functional layer; and an adhesion layer is arranged under the substrate layer. The functional layer employs a flexible and stretchable structure. Solution-based transfer printing technology is primarily used during the preparation of such a device to achieve integration of the functional layer and the flexible substrate layer. This device retains and even enhances the flexibility and stretchability structurally. Meanwhile, the biocompatibility properties thereof, such as being waterproof and air permeable, hypoallergenic, etc., allow it to work normally on the human body surface for more than 24 hours without foreign body sensation and discomfort, and thus, skin maceration, redness or other allergic reactions due to poor biocompatibility can be avoided.
    Type: Application
    Filed: December 3, 2015
    Publication date: November 30, 2017
    Applicant: Tsinghua University
    Inventors: Xue FENG, Ying CHEN, Honghong SU, Bingwei LU
  • Patent number: 9730935
    Abstract: Methods and compositions are provided for treating an individual having cancer. Aspects of the methods include administering to the individual an inhibitor of a non-canonical Notch signaling pathway gene in an amount effective to treat the cancer. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: August 15, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bingwei Lu, Kyu-Sun Lee
  • Patent number: 9719090
    Abstract: Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a Pumilio-like protein and/or an inhibitor of a serine/arginine-rich family of pre-mRNA splicing factor (SR) protein to a subject. Also provided are methods, compositions, systems and kits for transdifferentiating target cells to neurons, which find use in producing neurons for the development of new therapies, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example, for use in treating human disorders of the CNS.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 1, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bingwei Lu, Stephan Gehrke
  • Publication number: 20160151407
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Bingwei Lu, Seongsoo Lee
  • Patent number: 9289448
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 22, 2016
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Bingwei Lu, Seongsoo Lee
  • Patent number: 9265788
    Abstract: Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a mitochondrial transport protein to a subject having a mitochondrial disease. Also provided are reagents and kits for practicing the subject methods.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: February 23, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Song Liu, Bingwei Lu
  • Publication number: 20160030510
    Abstract: Methods of treating Alzheimer's disease and other tauopathies are disclosed. In particular, the invention relates to methods of treating Alzheimer's disease and other tauopathies with inhibitors of microtubule affinity regulating kinase (MARK). Hyperphosphorylation of tau by MARK is associated with the pathogenic deposition of intracellular neurofibrillary tangles and loss of synaptic markers, dendritic spines, and synapses during progression of Alzheimer's disease and other tauopathies. Peptide inhibitors derived from the Helicobacter pylori protein CagA block phosphorylation of tau in neuronal cells and thereby decrease the deposition of neurofibrillary tangles and the toxic effects of Abeta-42.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Inventors: Bingwei Lu, Jayakumar Rajadas, Dhananjay Wagh, Wendou Yu
  • Publication number: 20150344878
    Abstract: Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a Pumilio-like protein and/or an inhibitor of a serine/arginine-rich family of pre-mRNA splicing factor (SR) protein to a subject. Also provided are methods, compositions, systems and kits for transdifferentiating target cells to neurons, which find use in producing neurons for the development of new therapies, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example, for use in treating human disorders of the CNS.
    Type: Application
    Filed: December 20, 2013
    Publication date: December 3, 2015
    Applicant: The Board of Trustees of the Leland Stanford Junio r University
    Inventors: Bingwei Lu, Stephan Gehrke
  • Publication number: 20150174150
    Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).
    Type: Application
    Filed: March 17, 2014
    Publication date: June 25, 2015
    Applicant: BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Bingwei Lu, Seongsoo Lee
  • Publication number: 20150164896
    Abstract: Methods and compositions are provided for treating an individual having cancer. Aspects of the methods include administering to the individual an inhibitor of a non-canonical Notch signaling pathway gene in an amount effective to treat the cancer. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 18, 2015
    Inventors: Bingwei Lu, Kyu-Sun Lee
  • Publication number: 20140256786
    Abstract: Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a mitochondrial transport protein to a subject having a mitochondrial disease. Also provided are reagents and kits for practicing the subject methods.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 11, 2014
    Inventors: Song Liu, Bingwei Lu
  • Publication number: 20130331330
    Abstract: Methods of treating Alzheimer's disease and other tauopathies are disclosed. In particular, the invention relates to methods of treating Alzheimer's disease and other tauopathies with inhibitors of microtubule affinity regulating kinase (MARK). Hyperphosphorylation of tau by MARK is associated with the pathogenic deposition of intracellular neurofibrillary tangles and loss of synaptic markers, dendritic spines, and synapses during progression of Alzheimer's disease and other tauopathies. Peptide inhibitors derived from the Helicobacter pylori protein CagA block phosphorylation of tau in neuronal cells and thereby decrease the deposition of neurofibrillary tangles and the toxic effects of Abeta-42.
    Type: Application
    Filed: June 7, 2013
    Publication date: December 12, 2013
    Inventors: Bingwei Lu, Jayakumar Rajadas, Dhananjay Wagh, Wendou Yu