Patents by Inventor Bingxing Shi

Bingxing Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatopoietin and use thereof
    Patent number: 8361795
    Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: January 29, 2013
    Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA
    Inventors: Zuze Wu, Bingxing Shi, Chunping Cui, Shaojun Du, Danli Wu
  • Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof
    Patent number: 8212003
    Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: July 3, 2012
    Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLA
    Inventors: Bingxing Shi, Zuze Wu, Aiping Yu, Chunna Dong
  • HEPATOPOIETIN AND USE THEREOF
    Publication number: 20100144628
    Abstract: Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and promote the apoptosis of tumor cells. The hepatopoietin PCn (HPPCn) and its homologous proteins are useful for the treatment of acute and chronic liver injury, or the treatment of liver fibrosis.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 10, 2010
    Applicant: INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITA
    Inventors: Zuze Wu, Bingxing Shi, Chunping Cui, Shaojun Du, Danli Wu
  • Fused protein with the function of both hemolysis and anticoagulation and use of it
    Publication number: 20060127389
    Abstract: This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
    Type: Application
    Filed: September 3, 2003
    Publication date: June 15, 2006
    Inventors: Bingxing Shi, Zuze Wu, Aiping Yu, Chunna Dong