Abstract: Embodiments herein relate to systems and methods for intravascular lesion disruption. In an embodiment, a catheter system for imparting pressure to induce fractures upon a vascular lesion within or adjacent a blood vessel wall is included. The system includes a catheter configured to advance to a vascular lesion, the catheter including an elongate shaft that defines at least a first orifice for fluid flow; a balloon, coupled to the elongate shaft, that surrounds the first orifice where the balloon can expand from a collapsed configuration suitable for advancing the catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the catheter in position relative to a treatment site; and a propulsion system configured to propel a fluid from the first orifice toward the balloon wall to create an inertial impulse in a vessel wall to transfer momentum to the vascular lesion. Other embodiments are also included herein.

Abstract: A device receives network segment information identifying network segments associated with a network, and receives endpoint host session information identifying sessions associated with endpoint hosts communicating with the network. The device generates, based on the network segment information and the endpoint host session information, a data structure that includes information associating the network segments with the sessions associated with the endpoint hosts. The device updates the data structure based on changes in the sessions associated with the endpoint hosts and based on changes in locations of the endpoint hosts within the network segments, and identifies, based on the data structure, a particular endpoint host, of the endpoint hosts, that changed locations within the network segments. The device determines a threat policy action to enforce for the particular endpoint host, and causes the threat policy action to be enforced, by the network, for the particular endpoint host.

Abstract: Provided herein are methods and compositions of treating a condition by intratumorally administering MDM2 inhibitors. In some embodiments, the pharmaceutical compositions for intratumoral administration are formulated for controlled release and can comprise a biodegradable polymer.

Abstract: Methods and systems for administering directed fluidics during a medical procedure for removing an object are disclosed. A method includes inserting first and second medical instruments into a treatment site, providing irrigation and aspiration of the treatment site through the first and second medical instruments, determining a characteristic of one of the irrigation and the aspiration, and selecting a characteristic of the other of the irrigation and aspiration based on the determined characteristic.

Abstract: Provided herein are systems and methods for collaboratively assessing adherence to pharmaceutical regulations and performing inspections of a pharmaceutical facility, operable on a system including a computing device having a database server, a processor, a display, and a camera, wherein the systems and methods include performing data pulls by pulling information from a plurality of sources, pulling regulatory guidelines from a plurality of official regulatory bodies, and checking for updates to the information and the regulatory guidelines at predetermined intervals; such that the data received from the data pulls is used to assess the adherence to pharmaceutical regulations, perform the inspections, and answer input queries from a user related to the information and the regulatory guidelines.

Abstract: An arthroplasty system may include an arthroplasty prosthesis with a joint-facing side having an articular surface and a bone-facing side having a prosthesis attachment feature, a bone anchoring component, and a component attachment feature configured to translatably couple the bone anchoring component to the prosthesis attachment feature. In a first unlocked configuration, the component attachment feature and the prosthesis attachment feature may be translatably coupled with each other enabling the bone anchoring component to translatably move with respect to the bone-facing side of the arthroplasty prosthesis. In a second locked configuration, at least one of the component attachment feature and the prosthesis attachment feature may expand and secure a relative position of the component attachment feature to the prosthesis attachment feature and prevent the bone anchoring component from translatably moving relative to the bone-facing side of the arthroplasty prosthesis.

Abstract: A processing system including at least one processor may obtain a parking request for a vehicle to park at a parking facility and may offer a plurality of parking spots of the parking facility for the vehicle, where at least one of the plurality of parking spots that is offered is a parking spot that is predicted to be available, and where the offering includes presenting information regarding predicted adjacent parking spot occupancy of the at least one of the plurality of parking spots for a duration of an intended stay of the vehicle at the parking facility. The processing system may then obtain a selection of a parking spot from among the plurality of parking spots and reserve the parking spot for the vehicle.

Abstract: In one embodiment, a system to authorize a mobile electronic device to play games of chance includes a gaming system manager and a docking station, The docking station can be configured to: (i) detect whether the mobile electronic device is connected to a receiver of the docking station; (ii) receive device information from the mobile electronic device if it is detected that the mobile electronic device is connected to the receiver; (iii) determine whether a game of chance can be played on the mobile electronic device based on the received device information; (iv) authorize the mobile electronic device to play the game of chance; and (v) transmit gaming data to the mobile electronic device if it is determined that the game of chance can be played on the mobile electronic device and if the mobile electronic device is authorized.

Abstract: A method includes receiving a representation of a spoken utterance, processing the representation of the spoken utterance to identify, from a number of candidate domains, a request and a serving domain, and routing the request to a personal assistant based on the request and the serving domain. Identification of the serving domain is based on one or more of a contextual state, a behavior profile of a speaker of the utterance, and a semantic content of the utterance.

Abstract: Certain aspects relate to percutaneous sheaths for medical procedures as well as to related systems and methods. For example, a system for performing a percutaneous assisted medical procedure can include a percutaneous sheath. The percutaneous sheath can include a first conduit for providing aspiration into the kidney and a second conduit for passing a catheter into the kidney. The system can also include an aspiration catheter configured to be inserted into the kidney through the second conduit of the percutaneous sheath. A fluidics system can include an irrigation source comprising a pump and an aspiration source comprising a vacuum. The irrigation source can be connected to a fluid inlet of the percutaneous sheath that is connected to the first conduit. The aspiration source can be connected to the aspiration catheter.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: The present application describes an industrial drying apparatus for drying board precursor to form gypsum board, wherein the industrial drying apparatus comprises at least one electric heater. Use of the industrial drying apparatus and a method of drying a precursor board to form a gypsum board using the industrial drying apparatus are also described.

Abstract: In one embodiment, a system, apparatus, and method for distributing a portion of game information may include a gaming machine configured to play a game of chance and produce game information. A gaming server can be configured to communicate with the gaming machine, may establish a remote gaming session between the gaming machine and a user device, and may distribute the portion of the game information to the user device.

Abstract: A downhole separator separates solids from an inflow of downhole fluid resulting in a cleansed fluid which is directed to the intake of a subsurface pump. The downhole separator has a separator unit which has a sleeve member with a liner member disposed within the sleeve member, the liner member having an exterior surface immediately adjacent the inner surface of the sleeve member. The sleeve member has an opening which is aligned with an opening in the sleeve liner to form an inlet. A vortex guide is disposed inside an inner surface of the liner member. The vortex guide has a helical exterior which is in engaging contact of the inner surface, wherein a single helical passage is formed which extends from the inlet to a second end of the vortex guide.

Abstract: In some examples, a system includes a processor, a management controller; and a programmable device to provide input/output (I/O) expansion emulation to support communication with a plurality of I/O devices of a subsystem coupled to the system, where the programmable device provides a plurality of virtual registers as part of the I/O expansion emulation, the virtual registers associated with respective I/O devices of the plurality of I/O devices. The processor writes a value to a first virtual register of the plurality of virtual registers to trigger an output event relating to a first I/O device of the plurality of I/O devices at the subsystem. The management controller reads the first virtual register and, in response to the value written to the first virtual register, interact with the subsystem to issue the output event relating to the first I/O device at the subsystem.

Abstract: This disclosure involves verifying that a power network model corresponds to an electric power network providing electrical power in a geographical area. For instance, a validation device computes a validation score for a power network model based on a connectivity score, an asset score, and a power-flow score. The connectivity score indicates connectivity errors in the power network model as compared to the power network. The asset score indicates power-delivery errors in the power network model with respect to power-consuming assets serviced by the power network. The power-flow score indicates power-flow calculation errors in the power network model with respect to voltage ranges for the power network. The validation score is repeatedly computed for iteratively updated versions of the power network model until a threshold validation score is obtained. The validated power network model is provided to a control system for identifying and correcting errors in the power network.

Abstract: A knee joint prosthesis system for implantation in a first knee joint of a patient. The first knee joint has a condition. The knee joint prosthesis system includes a tibial baseplate component, a femoral component having a femoral articulation surface, and a tibial insert. The tibial insert includes a tibial articulation surface configured to articulate with the femoral articulation surface. The tibial articulation surface includes a medial tibial compartment asymmetrical to a lateral tibial compartment. The tibial articulation surface is shaped to cooperate with the femoral articulation surface to adapt kinematics of the first knee joint having the condition and the tibial articulation surface is also suitable for implantation in a second knee joint on a second side, the second knee joint lacking the condition.

Abstract: The disclosure includes a wallet comprising an open-sided shell, a flexible member coupled to the open-sided shell, and a pull tab coupled to the external surface of the flexible member. The disclosure also includes a wallet comprising an open-sided shell, a flexible member coupled to the open-sided shell, a stretchable band configured to wrap around the open-sided shell and the flexible member, and a radio frequency identification (RFID) protection plate coupled to the open-sided shell. In some embodiments, the RFID protection plate is configured to securably couple at least one personal card between the RFID protection plate and the open-sided shell. The disclosure includes a wallet comprising an open-sided shell, a first protruding portion coupled to the open-sided shell, and a second protruding portion coupled to the open-sided shell.

Abstract: The disclosure includes a wallet comprising an open-sided shell, a flexible member coupled to the open-sided shell, and a pull tab coupled to the external surface of the flexible member. The disclosure also includes a wallet comprising an open-sided shell, a flexible member coupled to the open-sided shell, a stretchable band configured to wrap around the open-sided shell and the flexible member, and a radio frequency identification (RFID) protection plate coupled to the open-sided shell. In some embodiments, the RFID protection plate is configured to securably couple at least one personal card between the RFID protection plate and the open-sided shell. The disclosure includes a wallet comprising an open-sided shell, a first protruding portion coupled to the open-sided shell, and a second protruding portion coupled to the open-sided shell.

Abstract: The present disclosure relates to a method for feeding back reliable downlink channel state information from a receiver to a transmitter in a multi-user massive MIMO system based on a reconfigurable intelligent surface, and more particularly, to a method for the receiver to transform acquired downlink channel state information into downlink channel state information in an angle domain and compress the downlink channel state information through a compressed-sensing scheme, and then feed the compressed result back to the transmitter, and for the transmitter to acquire the reliable downlink channel state information through a recovery algorithm. According to the present disclosure, the downlink channel state information is compressed according to a compression and recovery algorithm in an mmWave environment, and only a codeword index suitable for the compressed result is fed back to the transmitter to obtain the effect of reduction in feedback overhead in the entire communication system.