Patents by Inventor Binhau Zhou

Binhau Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyr393 and Tyr398 mutants of monoamine oxidase B
    Patent number: 6440714
    Abstract: Monoamine oxidase A and B (MAO A and B) are major neurotransmitter- and xenobiotic-metabolizing enzymes that are thought to play a role in psychiatric and neurological disorders. These isozymes have a high degree of identity in their nucleotide deduced amino acid sequences, but are encoded by different genes on the X-chromosome. Previous studies on MAO B have shown that FAD binds both noncovalently and covalently to specific amino acid residues that reside in highly conserved regions of MAO A and B. In the instant invention, it is demonstrated that the aromatic moieties at Tyr393 and Tyr398, which are located on each side of the covalent FAD binding residue (Cys397) participate in covalent FAD binding, and the generation of catalytically active MAO B.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: August 27, 2002
    Assignee: Research Development Foundation
    Inventors: Creed W. Abell, Binhau Zhou, Sau-Wah Kwan, Bo Wu
  • Tyr393 and Tyr398 mutants of monoamine oxidase B
    Publication number: 20020004233
    Abstract: Monoamine oxidase A and B (MAO A and B) are major neurotransmitter- and xenobiotic-metabolizing enzymes that are thought to play a role in psychiatric and neurological disorders. These isozymes have a high degree of identity in their nucleotide deduced amino acid sequences, but are encoded by different genes on the X-chromosome. Previous studies on MAO B have shown that FAD binds both noncovalently and covalently to specific amino acid residues that reside in highly conserved regions of MAO A and B. In the instant invention, it is demonstrated that the aromatic moieties at Tyr393 and Tyr398, which are located on each side of the covalent FAD binding residue (Cys397) participate in covalent FAD binding, and the generation of catalytically active MAO B.
    Type: Application
    Filed: March 30, 2001
    Publication date: January 10, 2002
    Inventors: Creed W. Abell, Binhau Zhou, Sau-Wah Kwan, Bo Wu