Abstract: The present invention relates to a cell gel preparation, which is used for treating and/or preventing acute or chronic osteoarthritis and/or symptoms thereof by means of intra-articular injection, wherein the preparation comprises a nucleic acid hydrogel loading mesenchymal stem cells. The present invention further relates to a method for treating or preventing acute and chronic osteoarthrosis and associated symptoms caused by inflammation (especially osteoarticular pain and activity or function loss) by means of using the cell gel preparation, and a method for reducing the shear damage on cells in a shear environment by means of using the nucleic acid hydrogel.