Abstract: A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.

Abstract: A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.

Abstract: A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.

Abstract: A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.

Abstract: An applicator for dispensing materials through a water jet device comprising a dispensing member having an inner cavity therein, the dispensing member comprises a plurality of openings thereover for allowing water and dispensing materials to enter and exit the cavity; and a cover serving as a removable tip of the water jet device, covering the dispensing member such that it forms a space between the cover and the dispensing member in the area of the openings of the dispensing member for containing a dispensing material therein. The applicator is configured for connecting to the water jet device such as to have water jet thereof directed through the cavity of the dispensing member and for dispensing allotted portions of the dispensing materials into the water jet through the openings of the dispensing member. The applicator is also configured for removably connecting to the water jet device for replacing and/or refilling thereof.

Abstract: An applicator for dispensing materials therethrough when using a water jet device, which includes: a dispensing member comprising a cannular member having an inner cavity therein, having a recess formed therein, where cannular member comprises openings thereover; and a cover covering the cannular member such as to enclose the recess to form a space between the cover and the cannular member in which the material is located. This space is configured for containing a material therein to allow dispending the contained material through the plurality of openings into the cavity of the cannular member to enable dispensing allotted portions of the material when a respective water jet is directed towards a respective jet tip of the water jet device. The applicator can be removable from the water jet device to allow replacing or refilling thereof and to allow using the water jet device without the applicator.

Abstract: A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.

Abstract: A sealant template for use in sealing a joint between a component and a vessel to which the component is attached comprises a support member on which are adhesively adhered inner and outer template sections. The inner template section has a ring-shape having an outer profile similar to but smaller than the periphery of the base of the component, and the outer template section has a ring-shape having an inner profile similar to but larger than the periphery of the base of the component. When the inner template section is adhesively adhered to the base of the component and the outer template section is adhesively adhered to the vessel surface, a ring-shaped gap exists between the inner and outer template sections at the joint between the component and the vessel to facilitate application of sealant to the joint. The inner and outer template sections may be provided with tabs to facilitate removal of the template sections from the backing member and adherence thereof to the component and the vessel.