Patents by Inventor Bipin Gaihre

Bipin Gaihre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMATERIALS CONTAINING UMBILICAL CORD-DERIVED STEM CELLS
    Publication number: 20240384235
    Abstract: Biomaterials containing viable stem cells, methods of making the biomaterials, and methods of promoting musculoskeletal tissue healing in a mammal. The stem cell-based regenerative biomaterial may include an active ingredient including umbilical cord-derived mesenchymal stem cells, isolated and expanded at low-oxygen similar to that experienced in degenerative human tissues. This preconditioning enables the injected stem cells to better adapt to the degenerative microenvironment resulting in improved viability.
    Type: Application
    Filed: May 19, 2023
    Publication date: November 21, 2024
    Inventors: Bipin Gaihre, Archana Bhat, Jason Leigl, Joshua Cige
  • Thermoresponsive or Shear-Thinning Injectable Gel Compositions for Treatment of Arthritis
    Publication number: 20240124567
    Abstract: The present invention relates to a thermoresponsive or shear-thinning gel composition comprising a recombinant factor (i.e., interleukin-1 receptor antagonist protein (IRAP) and/or platelet derived growth factor (PDGF)) and a carrier solution comprising at least one selected from hyaluronic acid (HA), chondroitin sulfate (CS), methyl cellulose (MC), and/or two-dimensional silicate nanomaterial. In some embodiments, the composition is an anti-inflammatory composition. Thus, in some embodiments, the present invention also provides a method of treating an inflammatory disease or disorder, such as osteoarthritis, using said composition.
    Type: Application
    Filed: October 12, 2022
    Publication date: April 18, 2024
    Inventors: Bipin Gaihre, Allison Adams, Archana Bhat, Jason Leigl
  • Thermoresponsive or Shear-Thinning Injectable Gel Compositions for Treatment of Arthritis
    Publication number: 20240123116
    Abstract: The present invention relates to a thermoresponsive or shear-thinning gel composition comprising a recombinant factor (i.e., interleukin-1 receptor antagonist protein (IRAP) and/or platelet derived growth factor (PDGF)) and a carrier solution comprising at least one selected from hyaluronic acid (HA), chondroitin sulfate (CS), methyl cellulose (MC), and/or two-dimensional silicate nanomaterial. In some embodiments, the composition is an anti-inflammatory composition. Thus, in some embodiments, the present invention also provides a method of treating an inflammatory disease or disorder, such as osteoarthritis, using said composition.
    Type: Application
    Filed: October 13, 2022
    Publication date: April 18, 2024
    Inventors: Bipin Gaihre, Archana Bhat
  • Thermoresponsive injectable microparticles-gel composites with low dose of recombinant BMP-9 and VEGF for bone repair
    Patent number: 11241504
    Abstract: Compositions for delivering one or more active substances, or for repairing a bone, and methods of making and using the same, are described.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: February 8, 2022
    Assignee: The University of Toledo
    Inventors: Ambalangodage C. Jayasuriya, Bipin Gaihre
  • Thermoresponsive Injectable Microparticles-Gel Composites with Low Dose of Recombinant BMP-9 and VEGF for Bone Repair
    Publication number: 20210023240
    Abstract: Compositions for delivering one or more active substances, or for repairing a bone, and methods of making and using the same, are described.
    Type: Application
    Filed: July 21, 2020
    Publication date: January 28, 2021
    Applicant: The University of Toledo
    Inventors: Ambalangodage C. Jayasuriya, Bipin Gaihre