Patents by Inventor Bipinchandra N. Desai
Bipinchandra N. Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6921767Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 and/or ?v?5 integrin.Type: GrantFiled: December 20, 2002Date of Patent: July 26, 2005Assignee: Pharmacia CorporationInventors: Nagarajan R. Srinivasan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
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Publication number: 20040092538Abstract: The present invention relates to a class of compounds represented by the Formula I 1Type: ApplicationFiled: December 20, 2002Publication date: May 13, 2004Inventors: Srinivasan R. Nagarajan, Ish Kumar Khanna, Michael Clare, Alan Gasiecki, Thomas Rogers, Barbara Chen, Mark Russell, Hwang-Fun Lu, Yu Yi, Renee M. Huff, Bipinchandra N. Desai, Balekudru Devadas, Mihir D. Parikh, Thomas Penning
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Publication number: 20040043994Abstract: The present invention relates to a class of compounds represented by the Formula I.Type: ApplicationFiled: January 21, 2003Publication date: March 4, 2004Inventors: Ish Kumar Khanna, Yi Yu, Hwang-Fun Lu, Nizal S. Chandrakumar, Renee M. Huff, Mark Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang
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Patent number: 6531494Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.Type: GrantFiled: August 29, 2001Date of Patent: March 11, 2003Assignee: Pharmacia CorporationInventors: Ish Kumar Khanna, Yi Yu, Balekudru Devadas, Hwang-Fun Lu, Nizal S Chandrakumar, Renee M. Huff, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Mark A. Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang
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Publication number: 20020072518Abstract: The present invention relates to a class of compounds represented by the Formula I 1Type: ApplicationFiled: August 29, 2001Publication date: June 13, 2002Inventors: Ish Kumar Khanna, Yi Yu, Balekudru Devadas, Hwang-Fun Lu, Nizal S. Chandrakumar, Renee M. Huff, Bipinchandra N. Desai, Srinivasan Raj Nagarajan
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Patent number: 5585492Abstract: The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.Type: GrantFiled: October 11, 1994Date of Patent: December 17, 1996Assignee: G. D. Searle & Co.Inventors: Nizal S. Chandrakumar, Barbara B. Chen, Michael Clare, Bipinchandra N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Chi-Dean Liang, Julie M. Miyashiro, Thomas D. Penning, Mark A,. Russell, Stella S. Yu
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Patent number: 5314895Abstract: The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof; wherein n is 0, 1 or 2;wherein R is H or lower alkyl of 1 to 6 carbon atoms;wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; andwherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano, or imidazolyl with the proviso that when n is 1, Ar is other then phenyl;pharmaceutical compositions containing these compounds and a method for treating cardiac arrhythmias in mammals by administering the compositions.Type: GrantFiled: March 11, 1993Date of Patent: May 24, 1994Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Konrad F. Koehler, Mark A. Russell
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Patent number: 5240943Abstract: The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof; wherein n is 0, 1 or 2;wherein R is H or lower alkyl of 1 to 6 carbon atoms;wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; andwherein Ar is selected from the group consisting of pyridinyl, tetrahydronaphthalenyl, benzofuranyl, and Ph--CH.dbd.CH-- and phenyl all optionally substituted by methane sulfonamide, nitro, cyano, or imidazolyl with the proviso that when n is 1, Ar is other then phenyl;pharmaceutical compositions containing these compounds and a method for treating cardiac arrhythmias in mammals by administering the compositions.Type: GrantFiled: December 19, 1991Date of Patent: August 31, 1993Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Konrad F. Koehler, Mark A. Russell
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Patent number: 5210090Abstract: The invention relates to compound of the formula ##STR1## useful in regulating cardiac arrhythmias. This invention also relates to pharmaceutical compositions of the above-described compounds.Type: GrantFiled: August 27, 1990Date of Patent: May 11, 1993Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Mark A. Russell
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Patent number: 5162365Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein the substituents are defined below. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: May 10, 1991Date of Patent: November 10, 1992Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 5098915Abstract: Substituted N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compunds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.Type: GrantFiled: September 5, 1989Date of Patent: March 24, 1992Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Kerry W. Fowler, Alan E. Moormann
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Patent number: 5097035Abstract: Compositions of matter are disclosed of compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents --CN, --CONH.sub.2, --CON(R.sub.1).sub.2 or --CO.sub.2 R.sub.1 where R.sub.1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R.sub.2 represents lower alkyl; R.sub.3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoroacetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R.sub.3 is lower alkyl, whereas when R.sub.3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.Type: GrantFiled: January 19, 1990Date of Patent: March 17, 1992Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Robert J. Chorvat, Kurt J. Rorig
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Patent number: 5053413Abstract: N-benzylpiperidineisoindolinones, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.Type: GrantFiled: September 5, 1989Date of Patent: October 1, 1991Assignee: G. D. Searle & Co.Inventor: Bipinchandra N. Desai
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Patent number: 5036105Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R.sub.3 isa) ##STR2## wherein R.sub.4 is hydrogen or lower alkyl; b) ##STR3## c) ##STR4## wherein R.sub.6 and R.sub.7 may be the same or different and are alkyl of 1 to 4 carbon atoms; ord) ##STR5## and the pharmaceutically acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: October 14, 1988Date of Patent: July 30, 1991Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 5028616Abstract: N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.Type: GrantFiled: September 5, 1989Date of Patent: July 2, 1991Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Kerry W. Fowler
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Patent number: 4801611Abstract: This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R.sub.3 is ##STR2## wherein R.sub.4 is hydrogen or lower alkyl; ##STR3## wherein R.sub.6 and R.sub.7 may be the same or different and are alkyl of 1 to 4 carbon atoms; or ##STR4## and the pharmaceuticlaly acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.Type: GrantFiled: May 7, 1987Date of Patent: January 31, 1989Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Bipinchandra N. Desai, Richard A. Mueller
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Patent number: 4639524Abstract: Compositions of matter are disclosed of compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents --CN, --CONH.sub.2, --CON(R.sub.1).sub.2 or --CO.sub.2 R.sub.1 where R.sub.1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R.sub.2 represents lower alkyl; R.sub.3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoracetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R.sub.3 is lower alkyl, whereas when R.sub.3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.Type: GrantFiled: July 9, 1984Date of Patent: January 27, 1987Assignee: G. D. Searle & Co.Inventors: Bipinchandra N. Desai, Robert J. Chorvat, Kurt J. Rorig
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Patent number: 4554353Abstract: This invention encompasses compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein n is 2 or 3 and R.sub.1 and R.sub.2 are n-propyl, isopropyl, or R.sub.1 and R.sub.2 together with N form a 2,6-dimethyl-1-piperidinyl group. The compounds of this invention are useful as antiarrhythmic agents.Type: GrantFiled: August 3, 1984Date of Patent: November 19, 1985Assignee: G. D. Searle & Co.Inventors: Robert J. Chorvat, Bipinchandra N. Desai
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Patent number: 4399279Abstract: 4H-1,4 benzothiazine derivatives having anorectic activity and their preparation including intermediate compounds are disclosed.Type: GrantFiled: April 30, 1982Date of Patent: August 16, 1983Assignee: G.D. Searle & Co.Inventors: Robert J. Chorvat, Bipinchandra N. Desai, Suzanne E. Radak
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Patent number: 4356302Abstract: 4H-1,4 benzothiazine derivatives having anorectic activity and their preparation including intermediate compounds are disclosed.Type: GrantFiled: March 9, 1981Date of Patent: October 26, 1982Assignee: G. D. Searle & Co.Inventors: Robert J. Chorvat, Bipinchandra N. Desai, Suzanne E. Radak