Abstract: A method, system and apparatus for filtering multi-energy images using spectral filtering technique is described. In one embodiment, the method includes obtaining a first image of an anatomical object corresponding to a first radiation energy. In addition, the method includes obtaining at least one additional image, herein called a second image of the anatomical object corresponding to at least one second radiation energy. The at least one second radiation energy is distinct from the first radiation energy. The method also includes determining joint attenuation characteristics of each tissue at the first radiation energy and at the second radiation energy or their derivatives. The method also includes selectively filtering attenuation value in a multi-energy space due to at least one tissue to generate a filtered image from a reference image. The reference image is one of the first image or the second image or their derivatives.